A5042380953- Hip disorders and treatments
- Bone and Joint Diseases
- Orthopaedic implants and arthroplasty
- Cardiac Valve Diseases and Treatments
- Bone fractures and treatments
- Bone health and treatments
- Orthopedic Infections and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Hip and Femur Fractures
- Bone Tissue Engineering Materials
- Osteoarthritis Treatment and Mechanisms
- Neurogenetic and Muscular Disorders Research
- Musculoskeletal synovial abnormalities and treatments
- Connective tissue disorders research
- Autoimmune and Inflammatory Disorders Research
- Genetic factors in colorectal cancer
- Spine and Intervertebral Disc Pathology
- Mesenchymal stem cell research
- Uterine Myomas and Treatments
- Pelvic and Acetabular Injuries
- Orthopedic Surgery and Rehabilitation
- Shoulder Injury and Treatment
- Graphene and Nanomaterials Applications
- Lower Extremity Biomechanics and Pathologies
- Advanced MRI Techniques and Applications
The University of Texas Southwestern Medical Center
2016-2025
Texas Scottish Rite Hospital for Children
2016-2025
Scottish Rite Freemasonry
2021-2024
Southwestern Medical Center
2015-2024
Center for Excellence in Education
2010-2024
Astrobotic (United States)
2023
Scottish Rite Hospital
2010-2023
Uppsala University
2022
Children's Hospital Colorado
2021
University of Colorado Denver
2021
Animal models for chondral shaving and subchondral abrasion were created to resolve the controversy about nature of repair tissue after these procedures determine effect continuous passive motion on quality tissue. Chondral was performed patella in forty adolescent rabbits, another rabbits. In both procedures, a three-millimeter-diameter defect created. After operation, twenty animals from each group allowed intermittent active motion; remainder treated by two weeks, followed motion. Half...
Arthrodesis of the hip remains a viable treatment for severe unilateral arthritis after traumatic injury or infection in young but otherwise healthy individual. The goal present study was to review long-term clinical and radiographic results conversion fused total arthroplasty identify risk factors that would lead higher rate failure.We performed retrospective charts radiographs 187 patients (208 hips) who had arthroplasty. mean duration follow-up 9.2 years (range, two twenty-six years).The...
We compared the effects of continuous passive motion with those intermittent active on results resurfacing autogenous periosteal grafts full-thickness defects articular surface rabbit patellae. Of 45 rabbits defects, 30 received grafts. Fifteen these had for two weeks and four weeks; other 15 six weeks. In were not grafted (control group) they Ten more a sham operation. Six after surgery, assessed by gross appearance, histology, histochemistry, immunohistochemistry electron microscopy. By...
Background: Femoral head deformity is the most serious sequela of ischemic necrosis immature femoral head. The purpose this study was to determine if a highly potent antiresorptive agent, ibandronate, can inhibit bone resorption during repair infarcted and thus alter process. We hypothesized that preservation trabecular framework by inhibiting osteoclastic would minimize development in piglet model necrosis. effect ibandronate on long-bone growth also assessed. Methods: Ischemic right...
The leading cause of oral pain and tooth loss is from caries their treatment include restoration using amalgam, resin, porcelain gold, endodontic therapy extraction. Resin composite restorations have grown popular over the last half a century because it can take shades more similar to enamel. Here, we discuss history use comparison between amalgam clinical procedures involved finishing polishing techniques for resin restoration. Although has aesthetic advantages one major disadvantage...
Traumatic fractures cause structurally unstable sites due to severe bone loss. Such generate a high yield of reactive oxygen species (ROS) that can lead oxidative stress. Excessive and prolonged ROS activity impedes osteoblast differentiation instigates long healing times. Stimulation antioxidants such as superoxide dismutase (SOD1), are crucial reduce ROS, stimulate osteogenesis, strengthen collagen mineral formation. Yet, no current fixative devices have shown an ability enhance matrix...
Background: The developing capital femoral epiphysis consists of a secondary center ossification surrounded by epiphyseal cartilage. Between the cartilage and is growth plate, which contributes to circumferential increase in size during development. main objective this study was describe histopathologic changes that occur plate surrounding early reparative phases following induction ischemic necrosis immature pigs. Methods: Ischemic induced eighteen piglets placing nonabsorbable suture...
A novel therapeutic strategy to decrease the development of femoral head deformity after ischemic osteonecrosis was studied in a large animal model total infarction. RANKL inhibition through exogenous osteoprotegerin administration significantly decreased pathologic bone resorption and during repair infarcted head.Legg-Calvé-Perthes disease (LCPD) is juvenile form that can produce permanent (FHD) premature osteoarthritis. The FHD LCPD closely associated with process, characterized by...
Bisphosphonate therapy has been shown to preserve the osteonecrotic femoral head in experimental and short-term clinical studies. However, a lack of new bone formation within preserved due inhibition remodeling is concern. The purpose this investigation was determine if combined consisting ibandronate morphogenetic protein-2 (BMP-2) can shape stimulate an immature animal model ischemic osteonecrosis.Ischemic osteonecrosis surgically induced pigs. Four groups were studied: normal, treated...
Current radiographic classifications for Legg-Calvé-Perthes disease cannot be applied at the early stages of disease. The purpose this study was to quantify perfusion femoral epiphysis in with use magnetic resonance imaging (MRI) and determine if extent epiphyseal can predict lateral pillar involvement mid-fragmentation stage.Twenty-nine patients had gadolinium-enhanced MRI initial stage or fragmentation were followed prospectively. percent whole its third measured by four independent...
Previous studies have confirmed that natural bone apatite crystals are bound with citrate-rich molecules. Citrates on impact development and its load-bearing function. However, such understanding has never been translated into biomaterials design. Herein, a first citrate-based injectable composite material for orthopedic applications is developed based our recently biodegradable poly(ethylene glycol) maleate citrate (PEGMC) hydroxyapatite (HA). PEGMC contains rich carboxylic groups could...
ABSTRACT Legg-Calvé-Perthes disease (LCPD) is a childhood hip disorder of ischemic osteonecrosis the femoral head. Hip joint synovitis common feature LCPD, but nature and pathophysiology remain unknown. The purpose this study was to determine chronicity inflammatory cytokines present in synovial fluid at an active stage LCPD. Serial MRI performed on 28 patients. T2-weighted gadolinium-enhanced MR images were used assess effusion enhancement (hyperemia) over time. A multiple-cytokine assay...
Local non-weight-bearing as a treatment for Legg-Calvé-Perthes disease remains controversial since clear scientific basis this is lacking. The purpose of study was to determine the effects on decreasing femoral head deformity following ischemic osteonecrosis and investigate its biological effects.Unilateral ischemia induced in sixteen piglets by placing ligature around neck transecting ligamentum teres. Eight animals received hind-limb amputation prevent weight-bearing side (NWB group)....
Background: Non-weight-bearing decreases the femoral head deformity but increases bone resorption without increasing formation in an experimental animal model of Legg-Calvé-Perthes disease. We sought to determine if local administration morphogenetic protein (BMP)-2 with or bisphosphonate can increase during non-weight-bearing treatment large Methods: Eighteen piglets were surgically induced ischemia. Immediately following surgery, all animals received above-the-knee amputation enforce...
Ischemic osteonecrosis of the femoral head in children is associated with chronic hip synovitis and increased levels pro-inflammatory cytokine interleukin-6 (IL-6) synovial fluid due to unknown mechanisms. The purpose this study was investigate hypoxia-inducible factor-1 (HIF-1) activation as a molecular mechanism linking induction ischemic IL-6 production initiation synovitis.Ischemic surgically induced right 6 piglets. A histologic score, volume, level were used assess synovitis....
Background: The absence of a reliable classification system for Legg-Calvé-Perthes disease has contributed to difficulty in establishing consistent management strategies and interpreting outcome studies. purpose this study was assess interobserver intraobserver reliability the modified Waldenström among large diverse group pediatric orthopaedic surgeons. Methods: Twenty surgeons independently completed first two rounds staging: assessments forty deidentified radiographs patients with various...