A5040067849- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Dental Implant Techniques and Outcomes
- 3D Printing in Biomedical Research
- Dental materials and restorations
- Orthopaedic implants and arthroplasty
- Muscle Physiology and Disorders
- High-Temperature Coating Behaviors
- Bone Metabolism and Diseases
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Endodontics and Root Canal Treatments
- Additive Manufacturing and 3D Printing Technologies
- Nuclear Materials and Properties
- Bone and Dental Protein Studies
- Semiconductor materials and devices
- Advanced ceramic materials synthesis
- Crystallization and Solubility Studies
- Mesenchymal stem cell research
- NF-κB Signaling Pathways
- Metal and Thin Film Mechanics
- Bone health and treatments
- Wound Healing and Treatments
- Thermodynamic properties of mixtures
- Nanoparticles: synthesis and applications
The University of Texas at Arlington
2018-2025
Texas A&M University
2014-2017
Texas A&M Health Science Center
2012-2017
Baylor University
2009-2016
Texas College
2016
North Carolina State University
2014
Baylor College of Medicine
2014
University of California, San Francisco
2006-2011
Oak Ridge National Laboratory
2007-2008
University of Florida
2004-2007
Traumatic fractures cause structurally unstable sites due to severe bone loss. Such generate a high yield of reactive oxygen species (ROS) that can lead oxidative stress. Excessive and prolonged ROS activity impedes osteoblast differentiation instigates long healing times. Stimulation antioxidants such as superoxide dismutase (SOD1), are crucial reduce ROS, stimulate osteogenesis, strengthen collagen mineral formation. Yet, no current fixative devices have shown an ability enhance matrix...
Abstract This study resulted in enhanced collagen type 1 and osteocalcin expression human periodontal ligament fibroblasts (hPDLF) when exposed to bioactive glass conditioned media that subsequently may promote early mineralized tissue development. Commercial Bioglass™ (45S5) experimental coating (6P53‐b), were used make a (GCM) for comparison control medium. ICP‐MS analysis showed increased concentrations of Ca 2+ , PO 4 3− Si 4+ Na + 45S5 GCM Mg K 6P53‐b (relative medium). Differentiating...
Peptide-based hydrogels have gained considerable attention as a compelling platform for various biomedical applications in recent years. Their attractiveness stems from their ability to seamlessly integrate diverse properties, such biocompatibility, biodegradability, easily adjustable hydrophilicity/hydrophobicity, and other functionalities. However, significant drawback is that most of the functional self-assembling peptides cannot form robust suitable biological applications. In this...
Inflammatory response in the dental pulp can alter collagen matrix formation by stem cells and lead to a delay or poor healing of pulp. This inflammatory is mediated cytokines, including interleukin-1β tumor necrosis factor-α. In this study, it hypothesized that suppressing actions these cytokines knocking down activity transcription factor Nuclear Factor-κB will cell differentiation into odontoblasts production collagen. Here, role signaling its reduction was examined during odontogenic...
Volumetric muscle loss injuries overwhelm the endogenous regenerative capacity of skeletal muscle, and associated oxidative damage can delay regeneration prolong recovery. This study aimed to investigate effect silicon-ions on C2C12 cells under normal excessive stress conditions gain insights into its role myogenesis during early stages regeneration. In vitro studies indicated that 0.1 mM Si-ions cell culture media significantly increased viability, proliferation, migration, myotube...
To investigate the effect of time between 3D printing and post-print processing (lag time) on modulus radiant energy penetration 3D-printed indirect bonding jig materials. Three resins (Formlabs IBT Resin, SprintRay IDB 2, Pro3dure GR-18.1 IB) were tested for three lag times (0, 16 64 h; n = 10 per group). Radiant was measured using a power meter, Vickers hardness assessed composites cured through samples. Mechanical properties evaluated uniaxial testing three-point bending. Both resin type...
Traumatic injuries lead to volumetric muscle loss (VML) and nerve damage that cause chronic functional deficits. Due the inability of mammalian skeletal regenerate after VML damage, engineered scaffolds have been explored address this challenge, but with limited success in restoration. We introduce novel bioactive amorphous silicon oxynitride (SiONx) biomaterials surface properties Si ion release accelerate cell differentiation for tissue regeneration. Micropatterned were designed developed...
This study tests the hypothesis that silicon and calcium ions combinatorially target gene expression during osteoblast differentiation. MC3T3-E1 subclone 4 progenitors (transformed mouse calvarial osteoblasts) were exposed to Si4+ (from Na2SiO3) Ca2+ CaCl2:H2O) ion treatments both individually (0.4 mM each + control treatment) 0.4 compared treated (α-minimum essential medium, 10% fetal bovine serum, 1% penicillin-streptomycin) cells. Cell proliferation studies showed no significant increase...
Abstract Current synthetic grafts for bone defect filling in the sinus can support new formation but lack ability to stimulate or enhance osteogenic healing. To promote such healing, osteoblast progenitors as human periosteum cells must undergo differentiation. In this study, we tested hypothesis that degradation of porous amorphous silica fibrous (PASF) scaffolds cell Two types PASF were prepared and evaluated according their densities (PASF99, PASF98) with 99 98% porosity, respectively....
Oxidative stress, induced by harmful levels of reactive oxygen species, is a common occurrence that impairs proper bone defect vascular healing through the impairment endothelial cell function. Ionic silicon released from silica-based biomaterials, can upregulate hypoxia-inducible factor-1α (HIF-1α). Yet it unclear whether ionic Si restore function under oxidative stress conditions. Therefore, we hypothesized help improve human umbilical vein cells' (HUVECs') survival toxic stress. In this...
Structurally unstable fracture sites require metal fixative devices, which have long healing times due to their lack of osteoinductivity. Bioactive glass coatings in interfacial bonding, delaminate, and reduced bioactivity the high temperatures used for fabrication. Here, we test hypothesis that low-temperature PECVD amorphous silica can enhance adhesion underlying surface N incorporation enhances osteogenesis rapid biomineralization. A model Ti/TiO2–SiOx interface was formed by first...
Lack of osteointegration is a major cause aseptic loosening and failure implants used in bone replacement. Implants coated with angiogenic biomaterials can improve potentially reduce these complications. Silicon- phosphorus-based materials have been shown to upregulate expression factors endothelial cell functions. In the present study, we hypothesize that amorphous silica-based coatings form silicon oxynitrophosphide (SiONP) by using plasma-enhanced chemical vapor deposition (PECVD)...
The bioactive silicon nitride (Si3N4) has been FDA cleared for use as spinal intervertebral arthrodesis devices. Because its surface properties promote bone ongrowth and ingrowth, it also the potential to benefit craniofacial reconstruction. Thus, aim of this work was determine whether Si3N4 could enhance osteoblast cell growth, differentiation nucleation hydroxyapatite (HA) crystals compared conventional implant materials such titanium (Ti) polyether ether ketone (PEEK). X-ray absorbance...
Silicon oxynitride (Si-O-N) is a new biomaterial in which its O/N ratio tunable for variable Si release and subsequent endocytotic incorporation into native hydroxyapatite enhanced bone healing. However, the effect of nitrogen hydrogen bonding on formation structure unclear. This study aims to uncover roles H N tuning Si-O-N surface bioactivity formation. Conformal films were fabricated by plasma-enhanced chemical vapor deposition (PECVD) onto Ti/Si substrates. Fourier transform infrared...