A5033064752- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Sulfur-Based Synthesis Techniques
- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Axial and Atropisomeric Chirality Synthesis
- Chemical synthesis and alkaloids
- Organoselenium and organotellurium chemistry
- Advanced Glycation End Products research
- Fluorine in Organic Chemistry
- Metal complexes synthesis and properties
- Tactile and Sensory Interactions
- Synthetic Organic Chemistry Methods
- Organometallic Compounds Synthesis and Characterization
- Biochemical effects in animals
- Virtual Reality Applications and Impacts
- Synthesis and Biological Evaluation
- Muscle activation and electromyography studies
- Parkinson's Disease Mechanisms and Treatments
- Chemical Synthesis and Reactions
- Molecular spectroscopy and chirality
- Dialysis and Renal Disease Management
- Synthesis and Catalytic Reactions
- Tracheal and airway disorders
- Advanced Proteomics Techniques and Applications
Jichi Medical University
2023-2025
Jichi Medical University Hospital
2025
The University of Texas Health Science Center at Houston
2025
Okayama University
2008-2024
Aichi Gakuin University
2016-2023
Kinjo Gakuin University
2019-2023
Mie University
2014-2023
National Hospital Organization
2021-2023
Nara Institute of Science and Technology
2020-2023
Nishi Niigata Chuo National Hospital
2023
Objectives: Alzheimer’s disease (AD) is the most common cause of dementia in elderly persons. Since pathology AD develops slowly from a preclinical or early phase into fully expressed clinical syndrome, at time diagnosis has been progressing for many years. To facilitate AD, we performed protein profiling blood patients with mild as defined by Functional Assessment Staging (FAST) scale.Methods: Plasma samples and healthy controls were analyzed using two-dimensional differential gel...
Stroke, especially in the aged population, affects lung health of stroke patients, and this influences outcome. Blood circulating CC-motif chemokine 11 (CCL11) increases rodents humans with age. Under aging-related pathological stress, lung-modified neutrophils (PMNs) can acquire a ‘damaging’ phenotype. Lungs release these PMNs into bloodstream, potentially exacerbate severity upon entering ICH-affected brains mice. Microglia (MG) are essential for hematoma clearance brain repair; however,...
A palladium-mediated domino reaction was developed to conveniently synthesize phenanthridinone derivatives. Phosphine ligand 1 strongly promotes the process, which includes aryl−aryl coupling and C−N bond formations concomitant with a deamidation reaction. The versatility applicability broad range of substrates make this useful for development bioactive
Novel optically active axially chiral amino acid and alcohols have been synthesized efficiently via lactam ring-opening, with the aid of an alcohol, amidoaza[5]helicene 5, which has readily prepared by additive-ligand-free Pd catalyzed domino coupling reaction in a single step. The stereostructures these molecules also clarified.
Inflammation enhanced by accumulation of reactive oxygen species plays an essential role in the progression cardiovascular diseases. Using 2D-oxyblot analysis and 2D-difference image gel electrophoresis (2D-DIGE), we compared levels ROS-induced carbonyl modification myocardial proteins whole left ventricles between 6-week-old hamsters with dilated (TO-2) hypertrophic cardiomyopathy (Bio14.6) control (F1B). Then, 2D combined MALDI-TOF/TOF tandem mass spectrometry detected 18 increased level...
Background/Aim: The aim of the present study was to determine clinical value tumor marker levels for previously treated NSCLC patients. Patients and Methods: We retrospectively screened 113 patients with advanced who were docetaxel monotherapy regarding pretreatment serum level cytokeratin 19 fragment (CYFRA21-1) carcinoembryonic antigen (CEA). Results: thirty-two normal CYFRA21-1 high CEA had a significantly higher response rate than other 81 (25% vs. 8.6%, p=0.031). former group showed...
Die enantioselektive Monofluorierung von α-Ketoestern gelang mithilfe eines mild basischen μ-Hydroxo-Palladiumkomplexes als Katalysator. anschließende Reduktion lieferte optisch aktive β-Fluor-α-hydroxyester, die in medizinisch relevante β-Fluor-α-aminoester überführt wurden. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by the authors. Please note: The...
In Parkinson's disease (PD), oxidative stresses cause cell death of dopaminergic neurons the substantia nigra (SN), but its molecular mechanism still remains unclarified. Our previous study proteomic analysis in monkey CA1 hippocampus after ischemia-reperfusion revealed reactive oxygen species (ROS)-induced carbonyl modification a chaperone, heat shock 70-kDa protein 1 (Hsp70.1), especially key site, Arg469. Here, to clarify neurodegeneration PD, SN tissue same experimental paradigm was...
Genomic prediction (GP) of breeding values using single nucleotide polymorphism (SNP) markers can be conducted even when pedigree information is unavailable, providing phenotypes are known and marker data provided. While use high-density SNP desirable for accurate GP, lower-density SNPs perform well in some situations. In the present study, GP was performed carcass weight marbling score Japanese Black cattle varying densities. The 1791 fattened steers with phenotypic 189 having predicted...
Background: Tyrosine kinase inhibitors (TKIs) directed against epidermal growth factor receptor (EGFR) are important in the treatment of non-small cell lung cancer (NSCLC), especially those harboring EGFR mutations. But little is known regarding clinical value serum tumor marker levels measured prior to treatment. Patients and Methods: We retrospectively reviewed 95 patients with advanced NSCLC treated EGFR-TKIs, inspected relationship between outcome. Results: Forty-three an elevated level...
As the field of utilization organic-inorganic hybrid molecules expands, toxicology these compounds is becoming more important. We have shown previously that there a strong correlation between cytotoxicity and intracellular accumulation detected as metal content, which modulated by substituents, molecules. In this study, we investigated pentavalent organoantimony with three phenyl groups on cultured vascular endothelial cells. The results indicated was not correlated hydrophobicity compounds....
This study aimed to investigate aclarubicin (ACR)-induced oxidative DNA damage and apoptosis.ACR-induced apoptosis was analyzed using HL-60 leukemia cells HP100 cells, hydrogen peroxide (H2O2)-resistant derived from cells. ACR-induced plasmid DNA.HL-60 were more sensitive ACR than In ladder formation caspase-3/7 activity induced by suppressed or delayed in comparison those occurred the presence of Cu(II), scavenger experiments showed that reactive species causing appeared be generated H2O2...
Pleasant touching is an important aspect of social interactions that widely used as a caregiving technique. To address the problems resulting from lack available human caregivers, previous research has attempted to develop robots can perform this kind pleasant touch. However, it remains unclear whether provide such touch in manner similar humans. investigate issue, we compared effect speed gentle strokes on back between and robot agents emotional responses participants (n = 28). A or stroked...