A5019508043- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Allergic Rhinitis and Sensitization
- Inhalation and Respiratory Drug Delivery
- Gastroesophageal reflux and treatments
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Drug Transport and Resistance Mechanisms
- Ion Channels and Receptors
- Sarcoidosis and Beryllium Toxicity Research
- Cancer therapeutics and mechanisms
- Medical Imaging and Pathology Studies
- Occupational and environmental lung diseases
- Sinusitis and nasal conditions
- Voice and Speech Disorders
- Neuroendocrine Tumor Research Advances
- Tracheal and airway disorders
- Urticaria and Related Conditions
- Dysphagia Assessment and Management
- Cancer Immunotherapy and Biomarkers
Nagoya City University
2016-2025
Nationwide Children's Hospital
2023
Nagoya Medical Center
2019-2022
American Thoracic Society
2022
Kyoto University
2012-2021
Mizuho (Japan)
2016-2021
Gunma University
2021
Juntendo University
2021
Hokuriku Electric Power Company (Japan)
2017-2020
University of Manchester
2020
Dupilumab has clinical effects in patients with moderate-to-severe asthma. When considering interleukin (IL)-4 and IL-13 signaling, of dupilumab on airway mucus hypersecretion remodeling are expected, but they have been reported only a few short-term studies. Its efficacy for hyperresponsiveness (AHR) remains unknown. We comprehensively assessed the dupilumab, especially subjective objective measures dimensions asthmatic patients. In 28 adult uncontrolled asthma, comprehensive 48-week...
Omalizumab, a humanized anti-IgE monoclonal antibody, has demonstrated efficacy in patients with severe allergic asthma. However, treatment responses vary widely among individuals. Despite lack of data, free serum IgE levels following omalizumab have been proposed as marker responsiveness.In this prospective, observational study, we assessed the utility biomarkers type 2 inflammation predicting responses, determined by absence asthma exacerbation during first year treatment. Free were...
Periostin is a matricellular protein that involved in the pathophysiology of allergic rhinitis, chronic rhinosinusitis, and asthma. Associations serum periostin with systemic airway eosinophilic inflammation comorbid rhinosinusitis patients asthma have been demonstrated. Although positioned as marker helper T cell 2 immune responses, its implication regarding presence upper diseases remains unclear.To investigate utility diagnostic biomarker for disease asthma.We prospectively enrolled 65...
Gastroesophageal reflux disease (GERD) is known as a common comorbidity of asthma and chronic cough. The impact GERD symptoms on cough-specific quality life (QoL) in patients with asthmatic cough poorly understood. aim this study to determine the association variant (CVA) using Leicester Cough Questionnaire (LCQ).A total 172 consecutive (121 females) mean duration 45.1 months (range 2-480 months) completed Japanese version LCQ. Frequency Scale for Symptoms was administered assess acid-reflux...
Although several computer-aided computed tomography (CT) analysis methods have been reported to objectively assess the disease severity and progression of idiopathic pulmonary fibrosis (IPF), it is unclear which method most practical. A universal classification system has not yet adopted for IPF.The purpose this study was test correlation between quantitative-CT indices lung physiology variables determine ability such predict in IPF.A total 27 IPF patients showing radiological UIP pattern on...
Abstract Computed tomography (CT) assessment of the cross-sectional area erector spinae muscles (ESM CSA ) can be used to evaluate sarcopenia and cachexia in patients with lung diseases. This study aimed confirm whether serial changes ESM are associated survival idiopathic pulmonary fibrosis ( IPF). Data from consecutive IPF who were referred a single centre retrospectively reviewed. We measured at level 12th thoracic vertebra on CT images referral 6 months later (n = 119). The follow-up...
Obesity affects the pathogenesis of various chronic diseases, including asthma. Research on correlations between obesity/BMI and eosinophilic inflammation in asthma has yielded contradictory results, which could be partly ascribed to absence epidemiological data correlations. We aimed elucidate blood eosinophil count, its genetic backgrounds, BMI general population. This community-based Nagahama study Japan enrolled 9789 inhabitants. conducted self-reporting questionnaires, lung function...
Rationale: Capsaicin cough reflex sensitivity (C-CS) is associated with poorly controlled asthma, although its association severe asthma remains unknown.Objectives: To determine the clinical impact of C-CS on asthma.Methods: We prospectively enrolled 157 patients (including 122 who were in step 4 or 5 according to Global Initiative for Asthma 2015 guidelines) between November 2016 and October 2019. A capsaicin challenge was performed along spirometry assessment biomarkers. The concentration...
Allergic rhinitis, a known risk factor for asthma onset, often accompanies mouth breathing. Mouth breathing may bypass the protective function of nose and is anecdotally considered to increase morbidity. However, there no epidemiological evidence that independently associated with morbidity sensitization allergens. In this study, we aimed clarify association between allergic/eosinophilic inflammation, while considering effect allergic rhinitis.This community-based cohort Nagahama Study,...
Abstract Background In steroid‐naive patients with asthma, several gene variants are associated a short‐term response to inhaled corticosteroid ( ICS ) treatment; this has mostly been observed in C aucasians. However, not many studies have conducted for other ethnicities. Here, we aimed determine the relationship between annual decline forced expiratory flow volume one second FEV 1 and variant of glucocorticoid‐induced transcript GLCCI Japanese asthma receiving long‐term treatment, taking...
While gastroesophageal reflux disease (GERD) is one of the commonest causes subacute/chronic cough along with cough-variant asthma (CVA) and rhinosinusitis, its clinical impact remains unknown. Therefore, we sought to investigate GERD in patients cough.Between April 2012 March 2018, a total 312 presenting subacute or chronic lasting for ≥3 weeks [median duration, 4.9 (0.7-434) months] underwent diagnostic tests. symptoms cough-specific QoL were evaluated through Frequency Scale Symptoms...
The serum creatinine/cystatin C (Cr/CysC) ratio has attracted attention as a marker for sarcopenia, but not been studied in patients with idiopathic pulmonary fibrosis (IPF). This study aimed to confirm the utility of Cr/CysC predicting sarcopenia and investigate its clinical relevance.This cross-sectional pilot prospectively enrolled stable IPF. IPF was diagnosed through multidisciplinary discussions according 2018 international guidelines, 2019 consensus report Asian Working Group...
Background The real-world efficacy of the P2X3 antagonist gefapixant, a new class antitussive for refractory chronic cough, is not yet fully understood. This study aimed to evaluate usage and response gefapixant in patients with cough. Methods multicentre, retrospective involved cough who visited clinics were prescribed gefapixant. Data collected included baseline demographics, characteristics, degree taste disturbance (both assessed by specialists), course after discontinuation, if...
Summary Background Epidemiological studies have shown that smoking increases the propensity for atopy and asthma. However, effects of on eosinophilic inflammation in asthmatics, including elderly, remain unknown. Objective To determine serum immunoglobulin E ( IgE ) levels asthmatics all ages. Methods The associations levels, blood eosinophil counts fractional exhaled nitric oxide FeNO with age steroid‐naive were cross‐sectionally assessed n = 307). Levels sputum thymic stromal lymphopoietin...
Sarcopenia is a syndrome characterized by reduced muscle mass and function. It well-recognized as complication in chronic diseases such obstructive pulmonary disease. However, little known about sarcopenia patients with idiopathic fibrosis (IPF). This study aimed to investigate the clinical characteristics of association between quality life IPF.In this pilot cross-sectional study, 56 Japanese outpatients IPF (49 men) were enrolled prospectively. was diagnosed according criteria Asian...