A5041777181- Respiratory and Cough-Related Research
- Asthma and respiratory diseases
- Antifungal resistance and susceptibility
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Insects and Parasite Interactions
- COVID-19 Clinical Research Studies
- Voice and Speech Disorders
- Indoor Air Quality and Microbial Exposure
- Long-Term Effects of COVID-19
- Fungal Biology and Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 and healthcare impacts
- Sinusitis and nasal conditions
- Glycosylation and Glycoproteins Research
- Respiratory viral infections research
- Infectious Diseases and Mycology
- Gastroesophageal reflux and treatments
- Mechanical Circulatory Support Devices
- Tracheal and airway disorders
- Plant Pathogens and Fungal Diseases
- Ion Channels and Receptors
- Pleural and Pulmonary Diseases
Kanazawa University
2000-2025
Kanazawa Hospital
2010-2025
Peptidream (Japan)
2020-2021
Kanazawa University Hospital
2008-2020
Nanao hospital
2014
Ishikawa Prefectural Central Hospital
1991-2014
Teikyo University
2013
City of Hope
2012
Beckman Research Institute
2012
Kyoto Sangyo University
2011-2012
Background The real-world efficacy of the P2X3 antagonist gefapixant, a new class antitussive for refractory chronic cough, is not yet fully understood. This study aimed to evaluate usage and response gefapixant in patients with cough. Methods multicentre, retrospective involved cough who visited clinics were prescribed gefapixant. Data collected included baseline demographics, characteristics, degree taste disturbance (both assessed by specialists), course after discontinuation, if...
A prospective multicentre study was conducted to elucidate the causes of chronic cough in Japan.All consecutive and unselected patients complaining lasting 8 weeks or more, who visited our clinics from 1 June 31 December 2001, were registered. The diagnosed based on criteria for definite probable as recommended by Japanese Cough Research Society.Of 248 enrolled, 72 (29.0%) unavailable follow up before their diagnostic assessment had been finalized. Among 176 adequately assessed, a diagnosis...
Nafamostat, a serine proteinase inhibitor with various actions including antithrombin, antiplasmin, and antitrypsin effects, has been used in clinical practice to treat disseminated intravascular coagulation (DIC) pancreatitis. This case report describes the course of patient COVID-19 pneumonia whose severe hypoxemia, probably caused by DIC pulmonary embolism, showed remarkable improvement combination heparin nafamostat therapy. In addition, beneficial mechanisms against necessity attention...
Chronic cough is the only symptom of variant asthma (CVA) and atopic (AC). Cysteinyl leukotriene receptor antagonists have been shown to be effective in CVA, but there are no reports on their effectiveness AC. To evaluate antitussive effect montelukast, a antagonist, CVA Seventy-five patients with chronic received diagnostic bronchodilator therapy oral clenbuterol hydrochloride for 6 days. Of 75 patients, 48 27 met simplified criteria AC, respectively. Patients were randomly divided into 3...
Lipoprotein diacylglyceryl transferase (Lgt) catalyzes the first step in biogenesis of Gram-negative bacterial lipoproteins which play crucial roles growth and pathogenesis. We demonstrate that Lgt depletion a clinical uropathogenic Escherichia coli strain leads to permeabilization outer membrane increased sensitivity serum killing antibiotics. Importantly, we identify G2824 as first-described inhibitor potently inhibits biochemical activity vitro is bactericidal against wild-type...
Chronic cough is one of the most common symptoms respiratory diseases and can adversely affect patients' quality life interfere with social activities, resulting in a significant burden. A survey required to elucidate frequency treatment effect chronic cough. However, clinical studies that cover all Japan have not yet been conducted. Patients who presented lasted longer than 8 weeks visited clinics or hospitals affiliated Cough Society during 2-year study period were registered. total 379...
It was previously reported that two oligonucleotide primer sets (spn9802 and spn9828) for discriminating Streptococcus pneumoniae from pneumococcus-like oral streptococcal isolates using PCR had been developed. In this study, amplification of the lytA, ply, spn9802 spn9828 genes used to identify presumptive S. pneumoniae. Two genetic groups were identified by analysing sputum samples 28 patients with community-acquired pneumonia: lytA-positive, ply-positive, spn9802-positive spn9828-negative...
Objectives. This controlled study was performed to clarify the therapeutic benefit of itraconazole for treatment patients with chronic cough, wherein a sputum culture yielded basidiomycetous (BM) fungi. Methods. Of 171 who visited our hospital diagnosis and BM detected in 39 patients. Informed consents were obtained from 21 subsequently enrolled this trial. After administration standard therapy, all randomized placebo-controlled 2 weeks low dose (50 mg/day) (n = 10) comparison corresponding...
Background: Although mucoid impaction of the bronchi (MIB) is a well-known manifestation in allergic bronchopulmonary mycosis (ABPM), when unknown samples or plural eumycetes are cultured from bronchial materials, several problems encountered which can affect definitive diagnostic process successful treatment. Case Summary: The two patients [a 58-(Case 1) and 70-(Case 2) year-old female] with MIB was: to identify existence any respiratory disorder, detect fungi obtained use 28S rDNA...
Abstract A high rate of thrombotic complications, such as pulmonary embolism, has been linked to mortality in COVID-19, and appropriate treatment thrombosis is important for lifesaving. Although heparin frequently used treat pathology embolism still seen severe cases. systemic fibrinolytic therapy a focus attention because the cause death it should be kept mind that might harmful at advanced stage COVID-19 where status disseminated intravascular coagulation (DIC) transmitted from...
Background. Recently, we have reported a new clinical disease concept called fungus-associated chronic cough (FACC), which entailed the following manifestations: (1) cough; (2) presence of environmental fungi, particularly basidiomycetous (BM) in sputum; and (3) good response to antifungal drugs. To clarify relationship between exposure fungi development attacks, reviewed records patients with FACC performed molecular biological analysis BM fungi. Methods. We successfully selected 8 cough,...
The presence of basidiomycetous (BM) fungi in induced sputum is an important clinical finding chronic idiopathic cough (CIC). However, the efficacy anti-fungal therapy for CIC has not been evaluated. We selected 10 patients with and carried out allergological examinations Bjerkandera adusta, a BM fungus that shown to enhance severity. low-dose itraconazole (ITCZ) (50 mg/day) 14 days as adjunctive was estimated use Cough Visual Analog Scale (Cough VAS) Japanese version Leicester Questionnaire...
Background. Recently, we have reported a new clinical disease concept called fungus-associated chronic cough (FACC), which entailed the following manifestations: (1) cough; (2) presence of environmental fungi, particularly basidiomycetous (BM) in sputum; and (3) good response to antifungal drugs. To clarify relationship between exposure fungi development attacks, reviewed records patients with FACC performed molecular biological analysis BM fungi. Methods. We successfully selected 8 cough,...
[Objective]The aim of the present study was to clarify influence sensitization Bjerkandera adusta(B. adusta)on clinical manifestation in patients with fungus-associated chronic cough(FACC).[Methods]Seventeen FACC who underwent bronchoprovocation tests using an antigenic solution B. adusta were selected from among 21 patients. We compared allergological findings and characteristics showed a positive reaction test(Allergic fungal cough sensitized adusta; AFC-Bj)with remaining patients(non...
Journal Article Surface plasmon resonance and NMR analyses of anti Tn-antigen MLS128 monoclonal antibody binding to two or three consecutive clusters Get access Ayano Matsumoto-Takasaki, Matsumoto-Takasaki 1Department Applied Biochemistry, Tokai University School Engineering, 4-1-1 Kitakaname, Hiratsuka, Kanagawa 259-1292; 2Structural Glycobiology Team, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198; 3Laboratory Glyco-organic Chemistry, The Noguchi 1-8-1 Kaga,...
We describe a patient who presented with hypoxemia and diffuse bilateral pulmonary infiltrates. The diagnosis of eosinophilic pneumonia was confirmed by bronchoalveolar lavage transbronchial lung biopsy. remarkable characteristic reappearance the symptoms on patient's return home, suggesting existence etiologic agents in his house. An environmental survey house yielded Alternaria alternata. A high liter anti‐ alternata antibody (IgG) detected serum, inhalation bronchoprovocation test A....