A5064096191- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Eosinophilic Esophagitis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gastroesophageal reflux and treatments
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Urticaria and Related Conditions
- Pancreatic and Hepatic Oncology Research
- Helicobacter pylori-related gastroenterology studies
- SARS-CoV-2 and COVID-19 Research
- Hearing, Cochlea, Tinnitus, Genetics
- Voice and Speech Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Clinical Nutrition and Gastroenterology
- Studies on Chitinases and Chitosanases
- Gastrointestinal disorders and treatments
Showa University
2019-2023
Kyoto University
2010-2021
University of Pittsburgh Medical Center
2019
University of Pittsburgh
2016-2019
Kumamoto University Hospital
2018
Kyoto Medical Center
2013-2015
Kawamura Hospital
2008-2012
Toray Industries, Inc. (Japan)
2012
Kumamoto City Hospital
2009
University of Yamanashi Hospital
2008
Omalizumab, a humanized anti-IgE monoclonal antibody, has demonstrated efficacy in patients with severe allergic asthma. However, treatment responses vary widely among individuals. Despite lack of data, free serum IgE levels following omalizumab have been proposed as marker responsiveness.In this prospective, observational study, we assessed the utility biomarkers type 2 inflammation predicting responses, determined by absence asthma exacerbation during first year treatment. Free were...
Gastroesophageal reflux disease (GERD) is known as a common comorbidity of asthma and chronic cough. The impact GERD symptoms on cough-specific quality life (QoL) in patients with asthmatic cough poorly understood. aim this study to determine the association variant (CVA) using Leicester Cough Questionnaire (LCQ).A total 172 consecutive (121 females) mean duration 45.1 months (range 2-480 months) completed Japanese version LCQ. Frequency Scale for Symptoms was administered assess acid-reflux...
Coronavirus disease 2019 (COVID-19) is globally rampant, and to curb the growing burden of this disease, in-depth knowledge about its pathophysiology needed. This was an observational study conducted at a single center investigate serum cytokine chemokine levels COVID-19 patients, based on severity. We included 72 consecutive patients admitted our hospital from March 21 August 31, 2020. Patients were divided into Mild-Moderate I (mild) Moderate II-Severe (severe) groups severity...
Background The real-world efficacy of the P2X3 antagonist gefapixant, a new class antitussive for refractory chronic cough, is not yet fully understood. This study aimed to evaluate usage and response gefapixant in patients with cough. Methods multicentre, retrospective involved cough who visited clinics were prescribed gefapixant. Data collected included baseline demographics, characteristics, degree taste disturbance (both assessed by specialists), course after discontinuation, if...
Persistent cough is a frequent cause of doctor and hospital visits, its incidence may be increasing. However, diagnosis the remains difficult. Because different causes have treatments, accurate critical. To gain better understanding in Japan, we performed multicenter epidemiological study Japanese patients.The involved seven institutions five areas was conducted over 1 year from March 2009. Patients aged ≥16 years attending participating centers for first time complaining persisting ≥3 weeks...
The character or timing of chronic cough is considered to be unpredictable for diagnosing its cause. However, the associations triggers with pathophysiology remains unknown.We developed a closed questionnaire listing 18 that were reported by ≥1% 213 patients in retrospective survey. Using this questionnaire, cough-predominant cough-variant asthma (n = 140) and those non-asthmatic (54) asked whether their was induced listed triggers. Associations causes cough, airway sensitivity inhaled...
A clinically relevant relationship between classic asthma and allergic rhinitis has been reported. However, the possible link cough variant (CVA) remains unknown.To clarify prevalence clinical relevance of perennial or seasonal in CVA patients compared to patients.We retrospectively studied adult with (n = 190) those 83). The associations concomitant severity, forced expiratory volume 1 s (% predicted), fractional exhaled nitric oxide (FeNO) levels, eosinophil proportions sputum blood were...
Abstract Background In steroid‐naive patients with asthma, several gene variants are associated a short‐term response to inhaled corticosteroid ( ICS ) treatment; this has mostly been observed in C aucasians. However, not many studies have conducted for other ethnicities. Here, we aimed determine the relationship between annual decline forced expiratory flow volume one second FEV 1 and variant of glucocorticoid‐induced transcript GLCCI Japanese asthma receiving long‐term treatment, taking...
Type III interferons (IFNs) play an important role in respiratory viral infections, including severe acute syndrome coronavirus 2 (SARS-CoV-2) infection. This study aimed to determine whether the expression of serum type IFNs predicted disease severity among patients with (COVID-19). A retrospective cohort was conducted admitted a single hospital between March 21, 2020, and 31, 2021. Patients were divided into mild moderate I (MM) II (MS) groups based on COVID-19 classification developed by...
Background and Study Aims: Vascular dilatation seen on percutaneous transhepatic cholangioscopy (PTCS) is diagnostic of intramural invasive carcinoma the bile duct, but limitations technique, including biopsy, for diagnosis extension duct have not to our knowledge been investigated before. The aims present study were estimate thickness specimens wall taken by assess sensitivity PTCS detecting carcinoma, identify characteristics associated with vascular dilatation.
Inflammation of peripheral airways is implicated in the pathophysiology severe asthma. However, contributions airway inflammation to caliber/function patients with stable asthma, including those mild moderate disease, remain be confirmed.To determine whether affects function asthma.In 70 alveolar nitric oxide [CANO(TMAD)] levels were examined as a noninvasive biomarker airway/alveolar inflammation. CANO(TMAD) and maximal (NO) flux compartment, J'awNO, estimated model that incorporated...
<b><i>Background:</i></b> Recent evidence suggests that YKL-40, also called chitinase-3-like-1 protein, is involved in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD). Details sputum YKL-40 COPD, however, remain unknown. <b><i>Objectives:</i></b> To clarify associations levels with clinical indices COPD. <b><i>Methods:</i></b> Thirty-nine patients asthma, 14 age-matched never-smokers as...
Summary Background Epidemiological studies have shown that smoking increases the propensity for atopy and asthma. However, effects of on eosinophilic inflammation in asthmatics, including elderly, remain unknown. Objective To determine serum immunoglobulin E ( IgE ) levels asthmatics all ages. Methods The associations levels, blood eosinophil counts fractional exhaled nitric oxide FeNO with age steroid‐naive were cross‐sectionally assessed n = 307). Levels sputum thymic stromal lymphopoietin...
Chronic cough is one of the most common symptoms respiratory diseases and can adversely affect patients' quality life interfere with social activities, resulting in a significant burden. A survey required to elucidate frequency treatment effect chronic cough. However, clinical studies that cover all Japan have not yet been conducted. Patients who presented lasted longer than 8 weeks visited clinics or hospitals affiliated Cough Society during 2-year study period were registered. total 379...
We have identified a urea transporter from the mucosa of human colon that has characteristics consistent with Kidd antigen/UT-B transporter. This intestinal encodes 389-amino acid peptide sequence identical to previously reported for UT-B in erythrocytes. Expression 2-kb mRNA transcript and approximately 50- 98-kDa proteins is detected colonic by Northern Western blot analysis. The protein localized cell membrane cytoplasm superficial epithelium epithelial cells crypts. A were also line...