A5018946764- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- IL-33, ST2, and ILC Pathways
- NF-κB Signaling Pathways
- Respiratory Support and Mechanisms
- Circadian rhythm and melatonin
- Immune Response and Inflammation
- Inhalation and Respiratory Drug Delivery
- Pediatric health and respiratory diseases
- Medical Imaging and Pathology Studies
- Epigenetics and DNA Methylation
- Obstructive Sleep Apnea Research
- Histone Deacetylase Inhibitors Research
- Gout, Hyperuricemia, Uric Acid
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Chemokine receptors and signaling
- Health and Wellbeing Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lipid Membrane Structure and Behavior
- SARS-CoV-2 detection and testing
- Telomeres, Telomerase, and Senescence
- Tracheal and airway disorders
National Hospital Organization
2021-2025
National Institute of Technology, Yonago College
2016-2025
Tottori University Hospital
2013-2024
Tottori University
1999-2023
Fujita Health University
1993-2019
Kindai University
2009-2017
Hokuriku Electric Power Company (Japan)
2017
Sendai Shakai Hoken Hospital
2009
Imperial College London
1999-2004
National Institutes of Health
2002-2004
Alveolar macrophages (AMs) are the predominant defense cells in airway, and their numbers increased smokers subjects with chronic obstructive pulmonary disease. This increase may result from recruitment, proliferation, or reduced cell death. Apoptosis regulates inflammatory survival, p21(CIP1/WAF1) is an important inhibitory regulator of cycle progression after oxidative stress. We have investigated whether smoke exposure influences expression localization apoptotic proteins AM bronchial...
Theophylline is well-established in the management of asthma, and there some evidence an antiinflammatory effect asthma. It not known whether theophylline affects inflammatory markers such as sputum eosinophils exhaled nitric oxide (NO) patients with mild asthma receiving inhaled steroid therapy. In a double-blind, placebo-controlled, cross-over study 15 we assessed low-dose therapy (250 mg twice per day) on induced sputum, bronchoalveolar lavage (BAL) airway biopsies at end both treatment...
Background. Various factors have been reported to be useful for predicting future exacerbations. Objective. This study was intended determine a usefulness of combination patient-based questionnaire, such as the Asthma Control Test (ACT) score with objective assessments, forced expiratory volume in 1 second (FEV1) and/or exhaled nitric oxide (FENO), exacerbations adult asthmatics. Methods. We therefore enrolled 78 subjects mild moderate asthma, who were clinically stable 3 months all had...
We explored whether the use of deep learning to model combinations symptom-physical signs and objective tests, such as lung function tests bronchial challenge test, would improve performance in predicting initial diagnosis adult asthma when compared conventional machine diagnostic method.The data were obtained from clinical records on prospective study 566 out-patients who visited Kindai University Hospital for first time with complaints non-specific respiratory symptoms. Asthma was...
Antimicrobial resistance is a global health concern, and methicillin-resistant Staphylococcus aureus (MRSA) one of the highest-priority organisms exhibiting this phenotype. Here, we performed national surveillance integrating patient clinical data S. isolated from bloodstream infections. We genome sequencing, standardized antimicrobial susceptibility testing, collected metadata 580 isolates during 2019–2020. focused on three predominant clonal complexes (CC1, CC5, CC8) assesses their...
The mammalian circadian clock is located in the suprachiasmatic nucleus (SCN) of hypothalamus and most peripheral tissues. Clock genes drive biological clock. However, expression variations human are still unclear. In this study, we analyzed daily mPer2 mClock mRNA both mouse SCN liver to evaluate central alterations rodent genes. We also examined whether there hPer2 hClock blood mononuclear cells (PBMCs). variation were determined at ZT2, ZT6, ZT10, ZT14, ZT18 or ZT22. isolated PBMCs from 9...
Abstract Background In steroid‐naive patients with asthma, several gene variants are associated a short‐term response to inhaled corticosteroid ( ICS ) treatment; this has mostly been observed in C aucasians. However, not many studies have conducted for other ethnicities. Here, we aimed determine the relationship between annual decline forced expiratory flow volume one second FEV 1 and variant of glucocorticoid‐induced transcript GLCCI Japanese asthma receiving long‐term treatment, taking...
GATA-binding proteins are a subfamily of zinc finger transcription factors with six members (GATA-1-6) that interact the GATA deoxyribonucleic acid (DNA) sequence. This sequence is found in regulatory regions many genes including those encoding T-helper 2 (Th2)-like cytokines, receptors, adhesion molecules and enzymes, which may be important pathogenesis bronchial asthma. The expression GATA-3, -4 -6 was investigated peripheral blood T-lymphocytes monocytes biopsies from 11 normal subjects...
Abstract IL-5 is implicated in the pathogenesis of asthma and predominantly released from T lymphocytes Th2 phenotype. In anti-CD3 plus anti-CD28-stimulated PBMC, albuterol, isoproterenol, rolipram, PGE2, forskolin, cholera toxin, cAMP analog, 8-bromoadenosine (8-Br-cAMP) all inhibited release lymphocyte proliferation. Although above compounds share ability to increase intracellular levels activate protein kinase (PK) A, PKA inhibitor H-89 failed ablate inhibition production mediated by...
The aim of the study was to characterize patients at risk for exacerbations their asthma as a result Tottori-Ken Seibu earthquake and identify factors that predict exacerbation after an earthquake. A retrospective cohort study-analysis conducted 156 asthmatic patients, aged 18 89 years, who were out-patients Tottori University Hospital had completely recorded symptoms measured peak expiratory flow (PEF) rates more than one year prior Seventeen (11%) experienced identified having within month...
An evidence-based diagnostic algorithm for adult asthma is necessary effective treatment and management. We present a that utilizes random forest (RF) an optimized eXtreme Gradient Boosting (XGBoost) classifier to diagnose as auxiliary tool. Data were gathered from the medical records of 566 outpatients who visited Kindai University Hospital with complaints nonspecific respiratory symptoms. Specialists made thorough diagnosis based on symptoms, physical indicators, objective testing,...
<i>Objective:</i> The expressions of minichromosome maintenance protein 2 (MCM2), Ki-67, and p53 were examined to analyze their pathobiological significance in human lung adenocarcinomas. <i>Methods:</i> We performed Western blot analysis six adenocarcinoma cell lines immunohistochemistry 145 surgically removed adenocarcinomas examine the MCM2 expression. Labeling indices (LIs; %) MCM2, tumor cells compared with clinicopathological profiles overall survival rates....
Objective: Asian dust storms (ADS) contain various airborne particles that may augment airway inflammation by increasing the level of interleukin-8. The objective study was to investigate association exposure an ADS with worsening symptoms adult asthma and effect on interleukin-8 transcriptional activity. Methods: subjects were 112 patients mild moderate who recorded scores for their daily upper lower respiratory tract measured morning peak expiratory flow (PEF) from March May 2011....
Genetic markers of susceptibility to asthma exacerbations in adults remain unclear.To identify genetic exacerbations, particularly patients with type-2 inflammatory endotype.In this observational study enrolled the Kinki Hokuriku Airway disease Conference multicenter study, frequency requiring systemic corticosteroids during 2 years after enrolment and associated risk factors was determined. For marker analysis, interleukin-4 receptor α (IL4RA) rs8832 a disintegrin metalloprotease 33...
The BNT162b mRNA vaccine for coronavirus disease 2019, which is caused by severe acute respiratory syndrome 2 (SARS-CoV-2), mimics the immune response to natural infection. Few studies have predicted adverse effects (AEs) after second-dose vaccination. We present a predictive model AEs and of vaccine.