A5090917430- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Asthma and respiratory diseases
- Dialysis and Renal Disease Management
- Helicobacter pylori-related gastroenterology studies
- Genetic Syndromes and Imprinting
- Central Venous Catheters and Hemodialysis
- Acute Kidney Injury Research
- Social Media in Health Education
- Cancer-related gene regulation
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Nosocomial Infections in ICU
- Chronic Kidney Disease and Diabetes
- Competitive and Knowledge Intelligence
- NF-κB Signaling Pathways
- Genetic Associations and Epidemiology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Legal and Policy Issues
- Complement system in diseases
- Immune Cell Function and Interaction
- Genomics and Rare Diseases
- Legal and Regulatory Analysis
- Cytokine Signaling Pathways and Interactions
- Cystic Fibrosis Research Advances
University of Michigan
2018-2021
University of Connecticut
2018-2021
The Ohio State University
2018-2021
University of Maryland, College Park
2018-2021
University at Buffalo, State University of New York
2018-2021
Public and Science
2018-2021
Michigan United
2018-2021
University of Iowa
2021
Smith College
2021
Syracuse University
2021
Airway wall remodelling and inflammation are features of chronic asthma. Transforming growth factor beta (TGF-beta) has been implicated in these processes.To determine the effect allergen challenge on airway whether TGF-beta isoforms Smad signalling pathways involved.Thirteen patients with atopic asthma underwent inhalational 0.9% saline, followed by 3-4 weeks later. After both challenges, fibreoptic bronchoscopy was undertaken to obtain bronchial biopsies tissue samples were processed for...
<i>Introduction:</i> Haemodiafiltration (HDF) has been reported to improve erythropoietin (EPO) responsiveness and phosphate clearance. We prospectively audited the effect of HDF on EPO dosages, weight serum phosphate. <i>Methods:</i> 34 patients dialyzing Tu/Th/Sa switched HDF, 44 M/W/F remained high-flux haemodialysis (HD) were followed for 12 months. <i>Results:</i> Dialysis adequacy (Kt/V start 1.56 ± 0.03 vs. HD 1.58 0.04 months 1.55 1.59 0.03),...
GATA-binding proteins are a subfamily of zinc finger transcription factors with six members (GATA-1-6) that interact the GATA deoxyribonucleic acid (DNA) sequence. This sequence is found in regulatory regions many genes including those encoding T-helper 2 (Th2)-like cytokines, receptors, adhesion molecules and enzymes, which may be important pathogenesis bronchial asthma. The expression GATA-3, -4 -6 was investigated peripheral blood T-lymphocytes monocytes biopsies from 11 normal subjects...
<i>Introduction:</i> Intradialytic hypotension remains the commonest complication of outpatient haemodialysis (HD) treatments. On-line haemodiafiltration (HDF) has been reported to reduce frequency intradialytic hypotension. We introduced on-line HDF into our satellite dialysis program, and prospectively audited effect on cardiovascular stability. <i>Methods:</i> 34 patients’ schedules (Tuesday/Thursday/Saturday) were converted online post-dilutional HDF, 44...
Background: Interleukin (IL)‐10 is a pleiotropic cytokine with broad spectrum of immunosuppressive and anti‐inflammatory effects. IL‐10 secretion from alveolar macrophages defective in patients asthma lower concentrations are found bronchoalveolar lavage (BAL) asthmatic than normal control subjects. Reduced may result exaggerated more prolonged inflammatory responses airways. acting through the receptor (IL‐10R) stimulates transcription factors STAT1 STAT3. Methods: We investigated IL‐10R...
DNA methylation is a key epigenetic modification involved in gene regulation whose contribution to disease susceptibility remains be fully understood. Here, we present novel Bayesian smoothing approach (called ABBA) detect differentially methylated regions (DMRs) from whole-genome bisulfite sequencing (WGBS). We also show how this can leveraged identify disease-associated changes methylation, suggesting mechanisms through which these alterations might affect disease. From data modeling...
Chronic kidney disease (CKD) related cardiovascular (CVD) is characterized by vascular remodelling with well-established structural and functional changes in the wall such as arterial stiffness, matrix deposition, calcification. These phenotypic resemble pathology seen ageing, are likely to be mediated sustained alterations gene expression, which may caused epigenetic tissue-specific DNA methylation. We aimed investigate tissue specific methylation that occur CKD-related CVD. Genome-wide...
A 66-year-old man with a recent radiographic diagnosis of parietal brain tumour presented severe left thigh pain that prevented ambulation. On examination, his anterior was mildly swollen without erythema. Initial concern for deep vein thrombosis in the setting malignancy or necrotising soft tissue infection. Subsequent imaging and biopsies revealed methicillin sensitive <i>Staphylococcus aureus</i> (MSSA) pyomyositis MSSA abscess.
Acute kidney injury (AKI) is associated with high morbidity and mortality, early recognition important. This article discusses the management of AKI in primary care a focus on medicines optimisation, describes when referral necessary.
<h3>Background</h3> Serum vitamin D levels have been related to asthma control and medication use in children with mild moderate disease, but little is known about the relationship between serum airway remodelling mucosal inflammation asthma. We hypothesised that lower would be associated increased lung function severe therapy resistant (STRA). <h3>Methods</h3> Nineteen aged 6 16 years STRA underwent spirometry, fiberoptic bronchoscopy, endobronchial biopsy, measurement of...
CD4<sup>+</sup> Foxp3<sup>+</sup> regulatory T (Treg) cells are key players in immune tolerance and tissue homeostasis. Their impact on homeostasis has been further reinforced by recent studies showing that Tregs control non-immunological processes. However, how Treg cell differentiation function influenced tissue-derived signals remain poorly understood. We here show a specific subset of tissue-resident macrophages can promote the stability Tregs. This distinctively express complement...
Purpose of review Patients who develop chronic kidney disease at an early age, or from uncertain cause, may benefit genomic sequencing approaches to define causative mutations and inform subsequent management. Recent findings Whole-exome has been used investigate the molecular genetic variants associated with in both specific phenotypes such as steroid-resistant nephrotic syndrome, large cohorts patients not selected for a certain diagnosis. These studies have shown that whole-exome is able...
Aims-To establish two cell lines from a primary duodenal adenocarcinoma; to describe the morphological, growth, ploidy, and immunophenotypic characteristics of these lines.Methods-The lines, designated DAC/S DAC/E, were characterised using both in vitro vivo culture techniques, light electron microscopy, immunocytochemistry, FACS analyses.Results-Both have an epithelial origin, are aneuploid display transformed cells. The differ each other morphology, doubling time serum requirements. These...
ABSTRACT DNA methylation is a key epigenetic modification involved in gene regulation whose contribution to disease susceptibility remains be fully understood. Here, we present novel Bayesian smoothing approach (called ABBA) detect differentially methylated regions (DMRs) from whole-genome bisulphite sequencing (WGBS). We also show how this can leveraged identify disease-associated changes methylation, suggesting mechanisms through which these alterations might affect disease. From data...
<h3>Background</h3> Studies of airway inflammation and remodelling may help us to understand the pathophysiology SA. Adult studies have shown mast cell within smooth muscle is specific asthma associated with hyperresponsiveness (AHR). However, this has not been studied in childhood disease. <h3>Hypothesis</h3> Children SA increased submucosal eosinophils cells compared age-matched mild asthmatics non-asthmatic controls. <h3>Methods</h3> 75 children, mean age 11.8 (5.6–17.3) years, 53 SA, 7...