A5052452618- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Salivary Gland Tumors Diagnosis and Treatment
- IgG4-Related and Inflammatory Diseases
- Neuroendocrine Tumor Research Advances
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Treatments and Mutations
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- COVID-19 Clinical Research Studies
- Lung Cancer Research Studies
- Japanese History and Culture
- Oral Health Pathology and Treatment
- Salivary Gland Disorders and Functions
- Pleural and Pulmonary Diseases
- Pediatric health and respiratory diseases
- Cancer Diagnosis and Treatment
- Food Allergy and Anaphylaxis Research
- Medical Imaging and Pathology Studies
- Dermatology and Skin Diseases
Showa University
2016-2025
Sapporo City General Hospital
2006-2024
Keio University
2024
Yamaguchi Red Cross Hospital
2023
Towada City Hospital
2017-2023
Showa University Hospital
2019-2022
Kagoshima University
2021-2022
National Graduate Institute for Policy Studies
2018-2021
Jikei University School of Medicine
2021
Kyushu University
2011-2020
Increased carotid intima-media thickness (IMT) and increased serum levels of inflammatory markers, such as C-reactive protein (CRP), interleukin (IL)-6, IL-18, are associated with an risk cardiovascular cerebrovascular diseases. The aim this study was to evaluate whether IMT, a useful marker for early atherosclerosis, is these markers in patients obstructive sleep apnea (OSA). Carotid IMT investigated ultrasonography 36 OSA 16 obese control subjects. Serum CRP, IL-6, IL-18 were measured at...
Mikulicz disease has been considered to be a subtype of Sjögren's syndrome (SS). However, recent studies have suggested that is an IgG4-related and distinguishable from SS. In addition, it reported both interleukin-4 (IL-4) IL-10 induce IgG4 production inhibit IgE. This study was undertaken examine the expression these cytokines in patients with SS.Labial salivary gland (LSG) sections 15 18 SS were examined for subsets infiltrating lymphocytes, patterns messenger RNA (mRNA)...
Silent brain infarction (SBI) and increased levels of soluble CD40 ligand (sCD40L) P-selectin (sP-selectin) are associated with an risk cerebrovascular disease.The aim this study was to evaluate whether SBI serum sCD40L sP-selectin in patients obstructive sleep apnea (OSA).SBI studied by magnetic resonance images 50 male OSA 15 obese control subjects who were free comorbidities. In addition, the effects 3 months treatment nasal continuous positive airway pressure (nCPAP) on parameters 24...
<h3>Objectives</h3> Interleukin (IL)-21 is mainly produced by CD4 T helper (Th) cells including Th2, Th17 and follicular (Tfh) cells. Recent studies have reported that IL-21 involved in the formation of germinal centres (GCs) class switching IgG4. It has been suggested IgG4-related dacryoadenitis sialoadenitis (IgG4-DS), so-called Mikulicz9s disease (MD), distinct from Sjögren9s syndrome (SS) shows a high frequency GC salivary glands. In this study expression IgG4-DS SS patients was...
Tumor-associated macrophages (TAMs) promote cancer cell proliferation, invasion, and metastasis by producing various mediators. Although preclinical studies demonstrated that TAMs preferentially express CD163 CD204, the TAM subsets in oral squamous carcinoma (OSCC) remain unknown. In this study, we examined expression role of OSCC. Forty-six patients with OSCC were analyzed for biopsy samples immunohistochemistry. We their production immune suppressive molecules (IL-10 PD-L1) peripheral...
Tumor-associated macrophages (TAMs) promote tumor progression and inhibit anti-tumor immune response by producing various mediators preferentially express CD163, CD204, CD206. However, the role of these TAM subsets in oral squamous cell carcinoma (OSCC) remains unclear. Here we investigated expression function OSCC, especially cancer proliferation. Biopsy sample from 44 patients with OSCC were examined for markers EGF immunohistochemistry. production isolated was assessed flow cytometry. We...
IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS) is characterized by bilateral swelling of glandular tissues with extensive fibrosis, immunologically considered a Th2-predominant disease. Recent studies reported that alternatively activated (M2) macrophages enhanced Th2 immune responses fibrosis production pro-fibrotic factors (IL-10, IL-13 CCL18). Therefore, we examined the association between M2 in submandibular glands from 7 patients IgG4-DS, 10 chronic sialoadenitis, Sjögren's...
The aim of this study was to investigate the initiation and progression autoimmune damage in lesions labial salivary glands (LSGs) from primary Sjögren's syndrome (SS) patients by examining selective localization T helper (Th) subsets such as Th1, Th2, Th17 regulatory cells (T(regs)) follicular (Tfh). expression cytokines transcription factors associated with these Th LSGs 54 SS 16 healthy controls examined using real-time polymerase chain reaction (PCR) immunostaining. Additionally,...
IgG4-related disease (IgG4-RD) is characterized by elevated serum IgG4 and marked infiltration of IgG4-positive cells in multiple organs. Interleukin-33 (IL-33) a recently described cytokine that secreted damaged epithelial cells, macrophages, dendritic potently activates helper T type 2 (Th2) immune responses, which have been suggested to play major role production IgG4-RD. Here, we assessed the expression IL-33 related molecules salivary glands (SGs) patients with IgG4-RD versus Sjögren's...
In the present study, authors examined relationship between lipid peroxidation and inflammation in patients with obstructive sleep apnoea (OSA). A total of 40 obese OSA were studied, along 18 12 lean subjects without OSA. Overnight excretion 8-isoprostane urine serum levels high-sensitivity C-reactive protein (hsCRP) measured. addition, effects 3 months’ treatment nasal continuous positive airway pressure (nCPAP) studied 20 moderate-to-severe urinary hsCRP significantly higher compared mild...
Epithelial cell death plays a critical role in hyperoxia-induced lung injury. We investigated the involvement of autophagic marker microtubule-associated protein-1 light chain-3B (LC3B) epithelial apoptosis after hyperoxia. Prolonged hyperoxia (>95% O(2)), which causes characteristic injury mice, activated morphological and biochemical markers autophagy. Hyperoxia induced time-dependent expression conversion LC3B-I to LC3B-II mouse vivo cultured cells (Beas-2B, human bronchial cells) vitro....
Abstract Introduction Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a new entity characterized by high serum IgG4 levels, IgG4-positive plasmacytic infiltration, and fibrosis in various organs. The purpose of this study was to determine the mechanism upregulation class switch recombination IgG4-RD. Methods We extracted RNA from peripheral blood mononuclear cells (PBMCs) patients with IgG4-RD ( n = 6), Sjögren syndrome (SS) healthy controls 8), CD3-positive T CD20-positive B sorted...
IgG4-related tubulointerstitial nephritis (TIN) shows characteristic serum IgG4 elevation and increased IgG4-positive plasma cells in the renal interstitium, inclusion of TIN as an systemic disease has been suggested. is rarest IgG subclass a Th2-dependent isotype with low affinity for target antigen. Although pathogenesis this not elucidated, positive immune complex hypocomplementemia some patients suggest that mechanisms are involved causation disease.We selected 20 cases histological...
Summary To investigate the pathogenesis of localized autoimmune damage in Sjögren's syndrome (SS) by examining expression patterns cytokines, chemokines and chemokine receptors at sites damage. mRNA these molecules labial salivary glands (LSGs) peripheral blood mononuclear cells (PBMCs) from 36 SS patients was examined using a real-time polymerase chain reaction-based method. Subsets infiltrating lymphocytes chemokines/chemokine LSG specimens were immunohistochemistry. Cytokines/chemokine...
IgG4-related disease (IgG4-RD) is a unique inflammatory disorder in which Th2 cytokines promote IgG4 production. In addition, recent studies have implicated the Toll-like receptor (TLR) pathway. This study was undertaken to examine expression of TLRs salivary glands (SGs) from patients with IgG4-RD.SGs 15 IgG4-RD, Sjögren's syndrome (SS), 10 chronic sialadenitis, and healthy controls were examined histologically. TLR family gene (TLR-1 through TLR-10) analyzed by DNA microarray submandibular...
Oral hypofunction is a new concept that addresses the oral function of older adults. Few studies have investigated relationship between and general health conditions such as frailty, sarcopenia, mild cognitive impairment. This paper explores these relationships in large-scale, cross-sectional cohort study. The with impairment were examined using data from 832 individuals who participated 2018 survey residents Tarumizu City, Kagoshima Prefecture, Japan. Individuals had significantly higher...
Abstract Background Eosinophilic granulomatosis with polyangiitis (EGPA) is a form of anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis characterized by eosinophil-rich granulomatous inflammation and small-to-medium vessel asthma, rhinosinusitis, eosinophilia. EGPA often difficult to distinguish from severe asthma eosinophilic chronic rhinosinusitis (ECRS) in cases when there are no findings that suggest vasculitis. Dupilumab, an anti-IL-4Rα monoclonal antibody, expected be...
Coronavirus disease 2019 (COVID-19) is globally rampant, and to curb the growing burden of this disease, in-depth knowledge about its pathophysiology needed. This was an observational study conducted at a single center investigate serum cytokine chemokine levels COVID-19 patients, based on severity. We included 72 consecutive patients admitted our hospital from March 21 August 31, 2020. Patients were divided into Mild-Moderate I (mild) Moderate II-Severe (severe) groups severity...
Matrix metalloproteinases (MMPs) are involved in the pathogenesis of cardiovascular diseases. We examined serum levels MMP-9 and its inhibitor, tissue inhibitor metalloproteinase-1 (TIMP-1), activity MMP-9, effect nasal continuous positive airway pressure (nCPAP) patients with obstructive sleep apnea syndrome (OSAS). After polysomnography, venous blood was collected at 5:00 A.M. from 44 OSAS 18 control subjects who were obese, TIMP-1, enzymatic measured. In addition, effects 1 month...
Heightened interest in oral health has lead to an increase patients complaining of xerostomia, which is associated with various mucosal disorders. In this study, we investigated the relationship between Candida species and disorders xerostomia.We evaluated whole salivary flow rate presence 48 xerostomia 15 healthy controls. The number was measured as colony-forming units after propagation on selective medium. Identification at level carried out by polymerase chain reaction restriction...