A5013772132- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Pneumonia and Respiratory Infections
- Lung Cancer Treatments and Mutations
- COVID-19 diagnosis using AI
- Inhalation and Respiratory Drug Delivery
- Respiratory viral infections research
- Medical Imaging and Pathology Studies
- Pediatric health and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Clinical Research Studies
- Lung Cancer Research Studies
- Ion Channels and Receptors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Colorectal Cancer Treatments and Studies
- Mycobacterium research and diagnosis
- SARS-CoV-2 and COVID-19 Research
- Occupational and environmental lung diseases
- Gastroesophageal reflux and treatments
- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- Nausea and vomiting management
- Legionella and Acanthamoeba research
- Indoor Air Quality and Microbial Exposure
- Nosocomial Infections in ICU
Kansai Medical University
2019-2025
University Medical Center
2019
Toyama City Hospital
2005-2017
Kouseiren Takaoka Hospital
2006-2009
Kanazawa University Hospital
2006-2009
Komatsu (Japan)
2009
Ishikawa Prefectural Central Hospital
2006-2009
Kanazawa Medical Center
2009
Kanazawa University
1995-2006
Fukui-ken Saiseikai Hospital
2006
Background The real-world efficacy of the P2X3 antagonist gefapixant, a new class antitussive for refractory chronic cough, is not yet fully understood. This study aimed to evaluate usage and response gefapixant in patients with cough. Methods multicentre, retrospective involved cough who visited clinics were prescribed gefapixant. Data collected included baseline demographics, characteristics, degree taste disturbance (both assessed by specialists), course after discontinuation, if...
Chronic cough is the only symptom of variant asthma (CVA) and atopic (AC). Cysteinyl leukotriene receptor antagonists have been shown to be effective in CVA, but there are no reports on their effectiveness AC. To evaluate antitussive effect montelukast, a antagonist, CVA Seventy-five patients with chronic received diagnostic bronchodilator therapy oral clenbuterol hydrochloride for 6 days. Of 75 patients, 48 27 met simplified criteria AC, respectively. Patients were randomly divided into 3...
The aim of this study was to evaluate the diagnostic utility a novel test kit that could theoretically detect all serogroups Legionella pneumophila for diagnosing pneumonia, in comparison with existing kits.This conducted 16 hospitals Japan from April 2016 December 2018. Three urinary antigen kits were used: (LAC-116), BinaxNOW (Binax), and Q-line Kyokutou (Q-line). In addition, sputum culture nucleic acid detection tests serum antibody performed where possible. accuracy correlations two...
Chronic cough is one of the most common symptoms respiratory diseases and can adversely affect patients' quality life interfere with social activities, resulting in a significant burden. A survey required to elucidate frequency treatment effect chronic cough. However, clinical studies that cover all Japan have not yet been conducted. Patients who presented lasted longer than 8 weeks visited clinics or hospitals affiliated Cough Society during 2-year study period were registered. total 379...
Mycoplasmapneumoniae is one of the major causative pathogens community-acquired pneumonia (CAP). M. pneumoniae CAP clinically and radiologically distinct from bacterial CAPs. One feature Japanese Respiratory Society (JRS) guidelines a trial to be carried out differentiate between for selection antibiotics. The purpose present study was clarify clinical radiological differences coronavirus disease 2019 (COVID-19) CAP. This conducted at 5 institutions assessed total 210 patients with 956...
Abstract Inflammatory mediators are involved in the pathogenesis of airway inflammation, but role prostaglandin I2 (PGI2) remains obscure. This study was designed to investigate PGI2 cough reflex sensitivity asthmatic airway, which is characterized by chronic eosinophilic inflammation. The effect beraprost, a chemically and biologically stable analogue PGI2, on response inhaled capsaicin examined 21 patients with asthma randomized, placebo-controlled cross over study. Capsaicin threshold,...
Indoor formaldehyde (FA) might worsen allergies and be an underlying factor for the increasing incidence severity of asthma; exact mechanism, however, remains unclear.The present study examined effects repeated exposure to FA on methacholine- antigen-induced bronchoconstriction in guinea-pigs vivo.First, non-sensitized were transnasally treated with 0.1 or 1.0% saline three times a week 6 weeks, concentrations methacholine (50, 100, 200 microg/mL) inhaled at 5-min intervals. Second,...
Aims Cough, one of the main symptoms bronchial asthma, is a chronic airway inflammatory disease with functionally damaged epithelium. Recently, we established an animal model cough hypersensitivity after antigen challenge and clearly showed protective effect carbocysteine in this model. This study was designed to investigate clinical for sensitivity patients asthma. Methods The effects two orally active mucoregulatory drugs, ambroxol hydrochloride, on response inhaled capsaicin were examined...
Sotrovimab, an antibody active against severe acute respiratory syndrome coronavirus 2 that neutralizes antibodies, reduced the risk of COVID-19-related hospitalization or death in studies conducted before emergence Omicron variant. The objective this study is to evaluate clinical efficacy sotrovimab patients with mild moderate COVID-19 BA.1 and BA.2 subvariant infections using a propensity score matching method. score-matched cohort population was derived from who received sotrovimab. We...
Sinobronchial syndrome is a cause of chronic productive cough. Inflammatory mediators are involved in the pathophysiology Accumulating evidences indicate that cyclooxygenase (COX)-2, one inducible isoforms COX, key element pathophysiological process number inflammatory disorders. However, little known about role COX-2 cough patients with sinobronchial as neutrophilic bronchial inflammation. The effect etodolac, potent inhibitor, on response to inhaled capsaicin was examined 15 randomized,...
Abstract: Cough, a frequent symptom encountered in clinical practice, often has considerable impact on patients’ lives. There is an urgent need to investigate more potent antitussive treatments for chronic refractory cough, particularly atopic which major cause of cough Japan. Previous studies have shown that eosinophilic tracheobronchitis with hypersensitivity sensory nerve C-fibers the pathophysiology cough. Gefapixant first-in-class P2X 3 antagonist recently become available use patients...
"Atopic cough" is a new clinical entity that presents with isolated chronic bronchodilator-resistant cough accepted in the Japanese Respiratory Society Guidelines for Management of Cough. The essential features are eosinophilic tracheobronchitis, increased reflex sensitivity and an atopic constitution. It has been suggested activated helper T lymphocytes cytokines which produced by these cells involved pathogenesis, but relationship between cell-derived airway remains unknown.The effect...
Bronchial responsiveness to acetaldehyde, a main factor in alcohol-induced bronchoconstriction, and methacholine were compared between 10 subjects with bronchoconstriction 16 asthmatic without alcohol sensitivity. In the alcohol-sensitive group, geometric mean (geometric SEM (GSEM)) of provocative concentration (PC20,meth) acetaldehyde (PC20,acet) causing 20% fall forced expiratory volume one second 0.947 mg x mL(-1) (GSEM 0.139) 21.0 0.112), respectively, which not significantly different...
Gastric ulcer and hemorrhage are major complications in patients with chronic respiratory failure, but upper GI endoscopy tends to be avoided because of possible cardiopulmonary events. This study was designed evaluate hypoxemia subsequent cardiac during gastroscopic procedures failure undergoing long-term home oxygen therapy (LHOT).Gastroscopy carried out 10 LHOT age-matched control subjects without pulmonary diseases. Oxygen saturation arrhythmias before gastroscopy were monitored....
The increased eicosanoid synthesis has been suggested as the underlying mechanism of chronic productive cough in patients with bronchitis.The effects orally active thromboxane A2 (TxA2) receptor antagonist seratrodast and cysteinyl leukotrienes (cLTs) pranlukast on response to inhaled capsaicin were examined sixteen stable bronchitis. Capsaicin threshold, defined lowest concentration eliciting five or more coughs, was measured an index airway sensitivity.The threshold significantly compared...
Abstract Aims Cough is a common symptom of bronchial asthma, chronic inflammatory airway disease. Recently, the therapeutic effects selective phosphodiesterase (PDE) inhibitors have been focused on asthma. This study was designed to investigate clinical effect PDE 3 inhibition cough reflex sensitivity in elderly patients with Methods Effects cilostazol, inhibitor, response inhaled capsaicin were examined 11 over 70 years stable asthma randomized, placebo-controlled cross study. Capsaicin...
Abstract Background Late asthmatic response is observed following antigen challenge in actively, but not passively, sensitized guinea pigs. Although cough reflex sensitivity increased after actively pigs, it unknown whether the antigen-induced increase develops passively animals. The aim of this study was to compare inhaled capsaicin an between and Methods Measurement number coughs elicited by increasing concentrations (10 -6 10 -4 M) bronchial responsiveness ascending methacholine, analysis...