A5069456682- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sarcoidosis and Beryllium Toxicity Research
- Renal and related cancers
- Occupational and environmental lung diseases
- Immunotherapy and Immune Responses
- Plant tissue culture and regeneration
- Transgenic Plants and Applications
- T-cell and B-cell Immunology
- Acute Lymphoblastic Leukemia research
- Systemic Sclerosis and Related Diseases
- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- Aortic Disease and Treatment Approaches
- Neonatal Health and Biochemistry
- Immune Cell Function and Interaction
- Aortic aneurysm repair treatments
- Chromosomal and Genetic Variations
- Neurological Disorders and Treatments
- Neuroscience of respiration and sleep
- Infectious Aortic and Vascular Conditions
- Streptococcal Infections and Treatments
- Infant Development and Preterm Care
- Dysphagia Assessment and Management
- Neurobiology of Language and Bilingualism
Shikoku Medical Center for Children and Adults
2016-2025
Nagoya City University
2018-2024
Nagoya City University Hospital
2023-2024
Aino University
2024
Kagawa University
2019
Shiga Medical Center
2018-2019
Teikyo University
2015
Université de Montréal
2014
Centre Hospitalier de l’Université de Montréal
2014
Mie University
2014
Antiviral cell–mediated immunity is initiated by the dendritic cell (DC) network in lymph nodes (LNs). Plasmacytoid DCs (pDCs) are known to migrate inflamed LNs and produce interferon (IFN)-α, but their other roles antiviral T unclear. We report that LN-recruited pDCs activated create local immune fields generate cytotoxic lymphocytes (CTLs) association with LNDCs, a model of cutaneous herpes simplex virus (HSV) infection. Although alone failed induce CTLs, vivo depletion impaired...
ABSTRACT Dissection of cardiomyocyte differentiation process at the cellular level is indispensable in research for cardiac development and regeneration. Previously, we have established an embryonic stem cell system that reproduces early vascular from progenitor cells express Flk1, a endothelial growth factor receptor, by combinatory application 2‐dimensional culture flowcytometry. Here show cardiomyocytes can be successfully induced single Flk1 + on culture, enabling direct observation...
The acquisition of arterial or venous identity is highlighted in vascular development. Previously, we have reported an embryonic stem (ES) cell differentiation system that exhibits early development using endothelial growth factor (VEGF) receptor-2 (VEGFR2)-positive cells as common progenitors. In this study, constructively induced and (ECs) vitro to elucidate molecular mechanisms arterial-venous specification.ECs were from VEGFR2+ progenitor with various conditions. VEGF was essential...
Abstract Computed tomography (CT) assessment of the cross-sectional area erector spinae muscles (ESM CSA ) can be used to evaluate sarcopenia and cachexia in patients with lung diseases. This study aimed confirm whether serial changes ESM are associated survival idiopathic pulmonary fibrosis ( IPF). Data from consecutive IPF who were referred a single centre retrospectively reviewed. We measured at level 12th thoracic vertebra on CT images referral 6 months later (n = 119). The follow-up...
There have been no reports on blood glucose meters for measurements in a wide variety of infant patients, from very preterm infants to mature and the early neonatal period onwards. In this study, we evaluated accuracy Glutest Mint II, point-of-care meter, by comparing levels measured device with those gas analyzer all gestational ages birth weights at number time points after birth. Infants aged 22 weeks 0 days gestation or older who were born any six tertiary intensive care units between...
The serum creatinine/cystatin C (Cr/CysC) ratio has attracted attention as a marker for sarcopenia, but not been studied in patients with idiopathic pulmonary fibrosis (IPF). This study aimed to confirm the utility of Cr/CysC predicting sarcopenia and investigate its clinical relevance.This cross-sectional pilot prospectively enrolled stable IPF. IPF was diagnosed through multidisciplinary discussions according 2018 international guidelines, 2019 consensus report Asian Working Group...
Sarcopenia is a syndrome characterized by reduced muscle mass and function. It well-recognized as complication in chronic diseases such obstructive pulmonary disease. However, little known about sarcopenia patients with idiopathic fibrosis (IPF). This study aimed to investigate the clinical characteristics of association between quality life IPF.In this pilot cross-sectional study, 56 Japanese outpatients IPF (49 men) were enrolled prospectively. was diagnosed according criteria Asian...
Abstract Background The main photochemical pathway in phototherapy for neonatal hyperbilirubinemia is the production and elimination (in bile or urine) of cyclobilirubin, which a structural photoisomer bilirubin, most efficiently produced by green light. Green light‐emitting diode ( LED ) phototherapy, however, has not been evaluated clinical setting because it recommended American Academy Pediatrics guidelines. We therefore compared efficacy blue patients with hyperbilirubinemia. Methods In...
Abstract Therapeutic drug monitoring is generally unnecessary in caffeine treatment for apnea of prematurity, as serum concentrations preterm infants are normally markedly lower than those at which intoxication occurs. However, several studies have reported having developed toxicity. This retrospective observational study, conducted a tertiary center Kagawa, Japan, aimed to evaluate the correlation between maintenance dose and determine leading suggested toxic levels. We included 24...
The effects of the removal oily surface film on initial swim bladder inflation and survival in cultured seven-band grouper Hyporthodus septemfasciatus were investigated during larval stage. Additionally, relationship between failure malformations later stages was examined. To explore promotion conditions for inflation, duplicate experiments conducted under three different water conditions: (ROF group), covering with an oil (COF sealing liquid paraffin (SLP group). Larval first observed 14...
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disease that causes mortality in most patients [1, 2]. Cough and dyspnoea are the common symptoms of IPF. However, effect cough on pathophysiology IPF has not been extensively investigated. Although with often described as dry [3], mucus hypersecretion ciliary impairment conducting airway reported to be among these [4]. Footnotes This manuscript recently accepted for publication ERJ Open Research . It published here its form prior...
Nintedanib has been shown to significantly reduce the annual rate of decline in forced vital capacity (FVC) patients with idiopathic pulmonary fibrosis (IPF) previous randomized trials. A 71-year-old man developed exertional dyspnea and was diagnosed IPF. Four months after treatment nintedanib, high-resolution computed tomography findings revealed reduced areas ground-glass opacity consolidation; 13 treatment, FVC showed improvement from 3.07 3.43 L, serum Krebs von den Lungen (KL)-6...
The peak expiratory flow rate (PEFR) is known to decrease in patients with sarcopenia. However, little about the clinical impact of PEFR idiopathic pulmonary fibrosis (IPF). This study aimed confirm whether a over 6 months was associated survival IPF patients.Consecutive who had been assessed at single center were retrospectively analyzed. relative decline assessed. Survival analyses performed by univariate and multivariate Cox proportional hazard models.A total 61 eligible cases (average...
Objective The daily step count is associated with mortality in idiopathic pulmonary fibrosis (IPF). However, the factors this phenomenon are not yet fully understood. We therefore clarified its association clinical parameters. Methods Fifty-nine patients IPF available data for counts; 6-minute walk distance (6MWD); chest, abdominal, and pelvic computed tomography (CT); function; psychological evaluations; sarcopenia assessments were prospectively enrolled. was measured continuously seven...
Bifidobacterium dentium strain JCM 1195(T) was isolated from human dental caries. Here, we report the complete genome sequence of this organism.