A5055429341- Neonatal and fetal brain pathology
- Asymmetric Synthesis and Catalysis
- Orthodontics and Dentofacial Orthopedics
- Non-Invasive Vital Sign Monitoring
- Colorectal Cancer Surgical Treatments
- Coordination Chemistry and Organometallics
- Neuroscience of respiration and sleep
- Cleft Lip and Palate Research
- Semiconductor Lasers and Optical Devices
- Chemical Synthesis and Reactions
- Synthetic Organic Chemistry Methods
- Optical Imaging and Spectroscopy Techniques
- Neonatal Health and Biochemistry
- Semiconductor Quantum Structures and Devices
- Advanced NMR Techniques and Applications
- Temporomandibular Joint Disorders
- Colorectal and Anal Carcinomas
- Organoboron and organosilicon chemistry
- dental development and anomalies
- GaN-based semiconductor devices and materials
- Thermal Regulation in Medicine
- Neonatal Respiratory Health Research
- Solid-state spectroscopy and crystallography
- Anorectal Disease Treatments and Outcomes
- Hydrogen's biological and therapeutic effects
Kagawa University
2015-2025
Fujieda Municipal General Hospital
2023
JEOL (Japan)
2011-2021
University of California, Santa Barbara
2003-2021
Organ Technologies (Japan)
2021
Takeda (Japan)
2017-2021
Nara Medical University
2007-2018
Aso Iizuka Hospital
2017
National Police Academy
2016
Perinatal Institute
2016
Abstract Purpose: The programmed death-1 ligand/programmed (PD-L/PD-1) pathway has been recently suggested to play a pivotal role in the immune evasion of tumors from host system. In this study, we tried reveal clinical importance and therapeutic potential PD-L/PD-1 pancreatic cancer, which is one most aggressive intractable malignant tumors. Experimental Design: We used immunohistochemistry investigate PD-L expression 51 patients with cancer who underwent surgery explored efficacy blocking...
Two recently proposed C13–13C recoupling methods under magic angle spinning (MAS), resonant interference (RIR), and C13–1H dipolar-assisted rotational resonance (DARR), are examined on a common theoretical foundation using the average Hamiltonian theory. In both methods, rf field is applied not C13 but H1 to recouple dipolar interactions, spectral overlap necessary conserve energy for polarization transfer achieved by line broadening. While DARR employs time-independent interactions...
We present full details of our new methods for preparing functionalized benzynes with lithium di-alkyl(2,2,6,6-tetramethylpiperidino)zincate (R2Zn(TMP)Li) through deprotonative zincation as a key reaction. In this system, by choosing appropriate ligands the zincate, either regioselective haloaromatics or generation substituted can be controlled in good yields excellent chemoselectivity, using same substrate. Zincation tBu2Zn(TMP)Li followed electrophilic trapping Me2Zn(TMP)Li nucleophilic...
Triple for all: Various optically active anti-β-nitro propargylic alcohols are synthesized by the catalytic stereoselective addition of nitroalkanes to ynals (the direct Henry reaction ynals). The utilization rich chemistry carbon–carbon triple bond allows rapid access three natural products. Detailed facts importance specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note:...
BAC to the future: Boronic acid catalysis (BAC) was applied direct activation of alcohols leading preparation carbocycles (see scheme), benzofurans, tetrahydrofurans, pyrrolidines, pyrans, piperidines, and various polycyclic compounds. The reactions proceed under mild conditions that circumvent use reactive leaving groups like halides. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They...
Magic-angle spinning (MAS) NMR is a powerful tool for studying molecular structure and dynamics, but suffers from its low sensitivity. Here, we developed novel helium-cooling MAS probe system adopting closed-loop gas recirculation mechanism. In addition to the sensitivity gain due temperature, present has enabled highly stable (vR=4-12 kHz) at cryogenic temperatures (T=35-120 K) over week without consuming helium cost electricity of 16 kW/h. High-resolution 1D 2D data were recorded...
Previous studies reported that eicosapentaenoic acid (EPA) was effective against any renal diseases including diabetic nephropathy. Monocyte chemoattractant protein-1 (MCP-1) is a regulating macrophage recruitment protein, which up-regulated in patients with The objectives of the present study were to evaluate effects EPA MCP-1 expression KKAy/Ta mice, production and signal transduction mouse mesangial cells (MMCs).KKAy/Ta mice injected ethyl ester (1 g/kg/day) intraperitoneally....
A regio- and chemoselective silylzincation reaction of various functionalized alkynes was developed using a newly designed dianion-type zincate. Silylzincation terminal alkynes, followed by electrophilic trapping, proved to be powerful tool for the one-pot, regiocontrolled generation trisubstituted alkenes. The vinylzincate intermediate also undergoes copper- palladium-catalyzed C−C bond-forming reactions in high yields with chemoselectivities.
Catalytic, highly enantioselective hydrophosphonylation of ynones has been achieved by exploiting the characteristic features in situ generated chiral tetraaminophosphonium phosphite.