A5020923386- Chronic Kidney Disease and Diabetes
- Advanced Glycation End Products research
- Renal Diseases and Glomerulopathies
- Diabetes Treatment and Management
- Dialysis and Renal Disease Management
- Diabetes Management and Research
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Alcohol Consumption and Health Effects
- Renin-Angiotensin System Studies
- Natural Antidiabetic Agents Studies
- Diabetes and associated disorders
- Oral microbiology and periodontitis research
- Eicosanoids and Hypertension Pharmacology
- Pancreatitis Pathology and Treatment
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Amyotrophic Lateral Sclerosis Research
- Acute Kidney Injury Research
- HIV/AIDS oral health manifestations
- COVID-19 Clinical Research Studies
- Parathyroid Disorders and Treatments
- Genetic Associations and Epidemiology
- Hormonal Regulation and Hypertension
- Diet and metabolism studies
Juntendo University
2016-2025
University of Oxford
2023
The University of Texas Southwestern Medical Center
2021
Juntendo University Hospital
2020
Suzuki (Japan)
2020
Harvard University
2012-2014
Joslin Diabetes Center
2012-2014
Brigham and Women's Hospital
2012
St. Marianna University School of Medicine
2009
China Medical University
2003
Levels of proinflammatory cytokines associate with risk for developing type 2 diabetes but whether chronic inflammation contributes to the development diabetic complications, such as ESRD, is unknown. In 1990s, we recruited 410 patients studies nephropathy and recorded their characteristics at enrollment. During 12 years follow-up, 59 developed ESRD (17 per 1000 patient-years) 84 died without (24 patient-years). Plasma markers systemic inflammation, endothelial dysfunction, TNF pathway were...
Elevated plasma concentrations of TNF receptors 1 and 2 (TNFR1 TNFR2) predict development ESRD in patients with type diabetes without proteinuria, suggesting these markers may contribute to the pathogenesis renal decline. We investigated whether circulating pathway determine GFR loss among diabetes. followed two cohorts comprising 628 diabetes, normal function, no proteinuria. Over 12 years, 69 developed estimated less than 60 mL/min per 1.73 m2 (16 1000 person-years). Concentrations TNFR1...
Red yeast rice has been used to produce alcoholic beverages and various fermented foods especially in East Asia. Since around March 2024, there have many cases of kidney dysfunction people who taken certain supplements containing red Japan. We experienced a case acute injuries induced after taking supplement rice. A 58-year-old woman was admitted our hospital due renal suspected be caused by the Benikoji CholesteHelp®, which contains With elevations urinary tubular injury markers such as...
Background. Upregulation of local monocyte chemoattractant protein-1 (MCP-1) production is involved in glomerular damage through macrophage recruitment and activation diabetic nephropathy. Treatment db/db mice with soluble receptor for advanced glycation end-products (RAGE) prevented macrophages to the glomeruli reduced albuminuria, suggesting that binding ligands RAGE may be MCP-1 expression. Therefore, we investigated role (AGEs) by podocytes signalling events after activation.
ANG-(1-7) is associated with vasodilation and nitric oxide synthase stimulation. However, the role of in type 2 diabetes mellitus unknown. In this study, we examined hypothesis that attenuates ANG II-induced reactive oxygen species stress (ROS)-mediated injury diabetic nephropathy KK-A(y)/Ta mice. mice were divided into four groups: 1) a control group; 2) II infusion 3) II+ANG-(1-7) coinfusion 4) II+ANG-(1-7)+d-Ala(7)-ANG-(1-7) (A779) group. addition, primary mesangial cells cultured then...
Chronic inflammation promotes the progression of diabetic nephropathy (DN). However, role TNF-α remains unclear. The objectives present study were to examine whether inhibition with a soluble TNF receptor (TNFR)2 fusion protein, i.e., etanercept (ETN), improves early stage DN in type 2 model KK-A(y) mouse and also investigate which pathway, TNFR1 or TNFR2, is predominantly involved this disease. ETN was injected intraperitoneally into mice for 8 wk. Renal damage evaluated by...
Prevalence of sarcopenia is high in patients with chronic kidney disease (CKD), especially those dialysis. Various pathological conditions related to CKD, such as inflammation, insulin resistance, and endothelial dysfunction, are thought be associated the development progression sarcopenia. Advanced glycation end products (AGE), one representative uremic toxins, have been shown contribute various CKD-associated complications. This study investigated role AGE frailty animals respectively. In...
Angiotensin-II induces nitro-oxidative stress in patients with diabetic nephropathy. Peroxynitrite and reactive oxide species can accelerate formation of advanced glycation end-products (AGEs). We investigated the effects candesartan, an angiotensin-II type 1 receptor blocker (ARB), on AGEs 2 KK/Ta mouse kidneys.KK/Ta mice were divided into three treatment groups: early group receiving 4 mg/kg/day candesartan from 6 to 28 weeks age, a late same dose 12 age vehicle for candesartan. BALB/c...
Abstract Relatively high circulating levels of soluble tumor necrosis factor (TNF) receptors (TNFRs: TNFR1, TNFR2) have been associated with not only progression to end-stage renal disease but also mortality in patients diabetes. It remains unknown whether elevated TNFR haemodialysis are mortality. We studied 319 receiving maintenance who were followed for a median 53 months. Circulating markers TNF pathway (TNFα and TNFRs) measured immunoassay. Strong positive correlations between TNFR1...
The current study aimed to examine whether the levels of TNF receptors 1 and 2 (TNFR1 TNFR2) in serum urine were associated with other markers kidney injury renal histological findings, including TNFR expression, IgA nephropathy (IgAN). parameters interest measured by immunoassay 106 biopsy-proven IgAN patients using samples obtained immediately before biopsy 34 healthy subjects. Renal findings evaluated immunohistochemistry. TNFRs higher than both or strongly correlated each (r > 0.9)....
Urinary kidney injury molecule-1 (KIM-1) has been associated with proximal tubular damage in human and animal studies. Although it recognized as a biomarker of acute chronic disease, its significance the serum remains unclear. Therefore, we examined relationship urinary KIM-1 levels renal parameters patients type 2 diabetes.
Previous studies reported that eicosapentaenoic acid (EPA) was effective against any renal diseases including diabetic nephropathy. Monocyte chemoattractant protein-1 (MCP-1) is a regulating macrophage recruitment protein, which up-regulated in patients with The objectives of the present study were to evaluate effects EPA MCP-1 expression KKAy/Ta mice, production and signal transduction mouse mesangial cells (MMCs).KKAy/Ta mice injected ethyl ester (1 g/kg/day) intraperitoneally....
We studied the serum concentration of tumor necrosis factor receptor 2 (TNFR2) and rate renal decline, a measure intensity disease process leading to end-stage (ESRD).A cohort 349 type 1 diabetic patients with proteinuria was followed for 5-18 years. Serum TNFR2, glycated hemoglobin A1c (HbA1c), other characteristics were measured at enrollment. used novel analytic approach, joint longitudinal-survival model, fitted serial estimates glomerular filtration (eGFR) based on creatinine (median...
It is unclear whether the effect of proteinuria on rapid kidney function decline equivalent among diabetic disease (DKD), non-DKD with diabetes (NDKD+DM), and nephrosclerosis without (NS-DM), particularly in advanced chronic patients.
To compare the risk of developing kidney outcomes with use glucagon-like peptide-1 receptor agonists (GLP-1RAs) versus sodium-glucose cotransporter-2 (SGLT2) inhibitors among individuals diabetes.
Abstract Diagnostic analysis of clinical markers including serum IgA levels and IgA/C3 ratio in patients with nephropathy is described. One hundred (IgA group) 100 other primary glomerular diseases (non‐IgA were examined. The was performed to distinguish between these two groups using four markers: 1) more than five red blood cells urinary sediments, 2) persistent proteinuria (urinary protein 0.3 g/day), 3) 315 mg/dl, 4) a 3.01. Patients three or easily diagnosed as having this study....
The KK/Ta strain serves as a suitable polygenic mouse model for the common form of type 2 diabetes associated with obesity in humans. Recently, we reported susceptibility loci contributing to and related phenotypes mice. In this study, focused on expression kidneys liver BALB/c mice using differential display (DD) PCR. Zn-alpha(2) glycoprotein-1 (Azgp1) mRNA levels were increased mice, sequence analysis revealed missense mutation. We analyzed relationship between polymorphism various 208 x...