A5063027879- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Lipoproteins and Cardiovascular Health
- Neonatal Respiratory Health Research
- Hydrogen's biological and therapeutic effects
- Neonatal Health and Biochemistry
- Infant Development and Preterm Care
- Thermal Regulation in Medicine
- Renal and Vascular Pathologies
- Hormonal Regulation and Hypertension
- Non-Invasive Vital Sign Monitoring
- Dye analysis and toxicity
- Optical Imaging and Spectroscopy Techniques
- Biochemical effects in animals
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Erythrocyte Function and Pathophysiology
- Blood Pressure and Hypertension Studies
- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Effects and risks of endocrine disrupting chemicals
- Cancer, Lipids, and Metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Intestinal and Peritoneal Adhesions
- Genital Health and Disease
- Heme Oxygenase-1 and Carbon Monoxide
Kagawa University
2007-2025
Kindai University
2024
Sakai Municipal Hospital
2024
Japan Pediatric Society
2023
Takamatsu University
2023
Kagawa University Hospital
2016
Nihon University
1998-1999
Akita Red Cross Hospital
1992
Kawasaki Medical School
1984-1989
Tohoku University
1975-1978
In Japan, the mortality rate of extremely low birth weight (ELBW) infants is notably in comparison with other developed countries, but prevalence chronic lung disease (CLD) and retinopathy prematurity (ROP) relatively high. This study aimed to estimate morbidity ELBW born 2015 who were admitted neonatal intensive care units (NICUs) Japan examine factors that affected short-term outcomes these infants. We also compared 2005, 2010, 2015.We analyzed mortality, morbidity, related infants, using...
Acute kidney injury (AKI) has been reported to occur in 30–70% of asphyxiated neonates. Hydrogen (H2) gas became a major research focus neonatal medicine after the identification its robust antioxidative properties. However, ability H2 ameliorate AKI is unknown. We examined histopathological injuries piglet renal cortex on day 5 hypoxic-ischemic (HI) insult and if can alleviate injuries. Twenty piglets were divided into three groups: no (Control, n = 6), HI alone (HI, 8), with ventilation...
Familial hypercholesterolemia (FH) is an underdiagnosed autosomal dominant genetic disorder characterized by high levels of plasma low-density lipoprotein cholesterol (LDL-C) from birth. This study aimed to assess the identification FH in children with LDL-C who are identified a universal pediatric screening Kagawa, Japan.In 2018 and 2019, 15,665 aged 9 or 10 years underwent lipid as part annual health checkups for prevention lifestyle-related diseases Kagawa prefecture. After excluding...
We previously reported the neuroprotective potential of combined hydrogen (H
Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C) levels, which increases the risk of premature coronary artery disease. Early detection and treatment are vital, especially in children. To improve FH diagnosis children, Japan Atherosclerosis Society (JAS) released new guidelines July 2022. This study assessed compared sensitivity specificity clinical diagnostic criteria from JAS pediatric 2017
Abstract Therapeutic drug monitoring is generally unnecessary in caffeine treatment for apnea of prematurity, as serum concentrations preterm infants are normally markedly lower than those at which intoxication occurs. However, several studies have reported having developed toxicity. This retrospective observational study, conducted a tertiary center Kagawa, Japan, aimed to evaluate the correlation between maintenance dose and determine leading suggested toxic levels. We included 24...
The antiviral and antibacterial properties of ozone gas have been utilised for air on-site disinfection. However, excess exposure is toxic to humans, necessitating the monitoring levels. While this has achieved using indicators, determining levels at intermediate time points during remains challenging owing current ones being capable measuring only endpoints. Shifts in endpoint are also difficult as coverage ranges indicators dependent on a single colour dye. indicator that covers wide range...
Abstract Background Familial Hypercholesterolaemia (FH) is an autosomal dominant genetic disorder that prevalent in one out of every 300 individuals the general population. Recognized as actionable condition, early diagnosis FH children crucial to prevent onset atherosclerosis, and equally important identification parents before development coronary artery disease events. Therefore, significance universal screening during childhood combined with reverse cascade has been increasingly...
Plasma renin activity (PRA) was measured in 38 cases of aortitis syndrome. The values resting peripheral vein blood PRA were 32.2±4.2 (SE) mμg/ml. These 3 times higher than those normal subjects. Hypertension due to renal arterial stenosis observed 18 cases. Their 41.2±6.0mμg/ml, while the remaining 20 patients without renovascular hypertension 24.2±5.4mμg/ml. belonging aortic arch type or extensive had 2 abdominal type. with obstruction common carotid arteries significantly these lesions....
Problematic Internet use (PIU) remains a significant social concern in Japan and across the globe. Numerous studies have been conducted to examine prevalence of PIU, its association with lifestyle habits mental health status. To best our knowledge, few examined between parental attachment PIU Japan. Furthermore, preventive measures primarily targeted adolescents via education. Therefore, this study we explored styles among seek new approach for development appropriate, effective measures.A...
The effect of furosemide on urinary kallikrein excretion was studied in 10 patients with essential hypertension and 9 normal volunteer subjects. After intravenous administration 2 hours upright posture, urine volume (UV), sodium (UNaV) potassium (UKV) excretion, plasma renin activity (PRA), aldosterone concentration (PAC) markedly increased. However, the augmentation (1.50±0.19 EU/2hr) less remarkable than that subjects (2.33±0.24EU/2hr), although same degrees response were observed PRA PAC....
It is important to identify the pathological characteristics of cerebral circulation and oxygen metabolism at bedside in children with congenital heart disease (CHD) prevent neurodevelopmental impairments. The brain regional saturation index (rSO2 ) can be easily obtained near-infrared spectroscopy has been widely used management CHD recent years.To determine if rSO2 before or after surgery a good predictor metabolism, we investigated impact different clinical variables on correlation...
HPLC analysis revealed that five subsidiary colors were present in a commercial Food Blue No. 1 (Brilliant FCF) product. Among them, major C, D, and E isolated. On the bases of spectroscopic analyses, their structures identified as disodium salt 2-[[4-[N-ethyl-N-(3-sulfophenylmethyl)amino]phenyl][4-[N-ethyl-N-(4-sulfophenylmethyl)amino]phenyl]methylio]benzenesulfonic acid,...
Perinatal hypoxic-ischemic brain injury of neonates remains a significant problem worldwide. During the resuscitation period, changes in cerebral hemoglobin oxygen saturation (ScO2) have been identified by near-infrared spectroscopy (NIRS). However, asphyxiated neonates, relationship between these and is not known. Three-wavelength time-resolved spectroscopy, an advanced technology for NIRS, allows estimation ScO2 blood volume (CBV). Here, we studied CBV during period after insult...
Background: Human milk banks have been established to provide human preterm infants who are unable obtain from their mothers. Donor screening methods vary, and prospective donors commonly screened for drug recreational substance use through behavioral screening. Although the risk of illegal consumption in Japan is extremely low, caffeine may be consumed unknowingly can found milk. To date, only a few reports conducted on concentration donor Research Aim: This study aimed examine...
Trichobezoar refers to the collection of ingested hair accumulating in gastric mucosa folds, which are found patients with trichotillomania and trichophagia. We present a case nine-year-old girl Japan who was have hypercholesterolemia universal lipid screening as part annual health checkups for prevention lifestyle-related diseases. Further examination revealed palpable mass without any digestive symptoms. Imaging studies patient's history pica indicated trichobezoar upper gastrointestinal...
Bohring-Opitz syndrome (BOS) is a rare disease with characteristic facial appearance and limb position. This report describes case of BOS complicated by persistent pulmonary hypertension the newborn (PPHN) formation abnormal alveoli that was confirmed autopsy. A female neonate born cesarean section at 37 weeks 2 days gestation found to have nevus flammeus, exophthalmos, palate, retraction mandible, posture BOS. The patients had severe PPHN requiring inhalation nitric oxide. Genetic testing...
Neonatal hypoxic-ischemic encephalopathy (HIE) is a significant cause of neonatal mortality and developmental disabilities. It has been revealed that the temporal behavior cerebral blood volume (CBV) carries information on degree hypoxia-ischemia. CBV can be estimated by means near-infrared spectroscopy. The change after insult related to during insult. In this paper, we consider mathematical model which governs time evolution We show predicted with Kalman filter based model.
It is important that blood glucose concentrations be accurately and conveniently measured in infants. However, especially the early neonatal period, point-of-care testing devices used for adults may not measure neonates.
<title>Abstract</title> Background Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn’s disease, are chronic disorders relating to gut microbiota dysbiosis. Despite severe pancolitis being more prevalent in pediatric UC than adult cases, alterations the colon mucosa-associated (MAM) their association with disease severity remain be elucidated. The present study aimed compare lavage fluids (CLFs) fecal samples from patients. Results A total of 140 CLFs 23 19 each...
A magenta subsidiary colour was isolated from commercial Food Blue No. 1 (B-1; Brilliant FCF). The absorption maximum for this at 580 nm is outside of the range 614-628 found other colours and m,m-B-1. On basis MS NMR analyses, structure elucidated as disodium salt 2-[[4-[N-ethyl-N-(3-sulphophenylmethyl)amino]phenyl][4-oxo- 2,5-cyclohexadienylidene]methyl]benzenesulphonic acid. HPLC analyses revealed that 24 batches (three manufacturers) contain 0.1-0.8% (average: 0.5%) colour.
Abstract Two neoplastic human cell lines, WI‐38 CT‐1 and SUSM‐1, which were transformed in vitro with gamma rays 4‐nitroquinoline 1‐oxide, respectively, grew continuously a serum‐free defined medium. The medium used was 1:1 mixture by volume of Dulbecco's modified Eagle's Ham's F12 (DF) supplemented 0.1% bovine serum albumin fraction V, 10 μg/ml transferrin, 1 insulin, 5 oleic acid. In the case 100 fetuin added to cultures when cells subcultured. Under these conditions growth rates two lines...