A5081486505- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Hydrogen's biological and therapeutic effects
- Liver Disease Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Thermal Regulation in Medicine
- Neonatal Health and Biochemistry
- Cardiac Arrest and Resuscitation
- Lipoproteins and Cardiovascular Health
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Esophageal and GI Pathology
- Inflammatory Bowel Disease
- Folate and B Vitamins Research
- Streptococcal Infections and Treatments
- Gut microbiota and health
- Microscopic Colitis
- Diet, Metabolism, and Disease
- Eosinophilic Disorders and Syndromes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Carbohydrate Chemistry and Synthesis
- Amoebic Infections and Treatments
- Blood groups and transfusion
- Health and Medical Research Impacts
- Cancer, Lipids, and Metabolism
Kagawa University
2014-2025
BACKGROUND Heterozygous familial hypobetalipoproteinemia (FHBL) is a semi-autosomal disorder that caused mainly by an APOB variant. It usually asymptomatic and rarely leads to non-alcoholic steatohepatitis (NASH). CASE SUMMARY A 12-year-old boy was referred our hospital after prolonged elevation of liver enzymes observed during health checkups in Kagawa Prefecture. Abdominal ultrasound showed bright liver, laboratory investigations revealed low low-density lipoprotein cholesterol...
We previously reported the neuroprotective potential of combined hydrogen (H
Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C) levels, which increases the risk of premature coronary artery disease. Early detection and treatment are vital, especially in children. To improve FH diagnosis children, Japan Atherosclerosis Society (JAS) released new guidelines July 2022. This study assessed compared sensitivity specificity clinical diagnostic criteria from JAS pediatric 2017
Abstract Despite its poor outcomes, therapeutic hypothermia (TH) is the current standard treatment for neonatal hypoxic-ischaemic encephalopathy (HIE). In this study, due to antioxidant, anti-inflammatory, and antiapoptotic properties, effectiveness of molecular hydrogen (H 2 ) combined with TH was evaluated by means neurological histological assessments. Piglets were divided into three groups: insult normothermia (NT), (TH, 33.5 ± 0.5 °C), H ventilation (TH-H , 2.1–2.7%). administered 24 h....
Abstract D ubin– J ohnson syndrome ( DJS ) is an autosomal recessive inherited disorder characterized by conjugated hyperbilirubinemia. Neonatal‐onset rare. It caused dysfunction of adenosine triphosphate‐binding cassette, sub‐family C , member 2 ABCC2 ). We found a novel compound heterozygous mutation ‐related gene: W709R T2145C ): missense in exon 17, and R768W C2302T ), 18. Serum diglucuronosyl bilirubin/monoglucuronosyl bilirubin ratio was high. may excrete preferentially over...
The aim of this study was to use near-infrared time-resolved spectroscopy (TRS) determine the absolute values cerebral blood volume (CBV) and hemoglobin oxygen saturation (ScO2) during immediate transition period in term neonates changes optical properties such as differential pathlength factor (DPF) reduced scattering coefficient (μs’). CBV ScO2 were measured using TRS first 15 min after birth by vaginal delivery who did not need resuscitation. Within 2–3 birth, showed various increases or...
Paediatric splenic abscesses are rare, but can be fatal. An 8-year-old boy developed recurrent fever and abdominal pain 5 months after undergoing an appendectomy. A CT scan showed rectovesical pouch abscesses. The patient was successfully treated with antibiotics, laparoscopic drainage debridement of pus from the abscess. Eggerthella lenta cultured latter lesion. Early diagnosis treatment resulted in satisfactory resolution infection.
Traditional serrated adenoma (TSA) is a type of polyp the colorectum and thought to be precancerous lesion. There are three types polyps, namely, hyperplastic sessile adenomas/polyps, TSAs. TSA least common accounts for about 5% polyps. Here we report pediatric case that was successfully resected by endoscopic submucosal dissection (ESD). This rare describes patient with no family history colonic who admitted our hospital hematochezia. On colonoscopy, found polypoid lesion measuring 10 mm in...
Therapeutic hypothermia (TH) is a standard therapy for neonatal hypoxic-ischaemic encephalopathy. One potential additional the free radical scavenger edaravone (EV; 3-methyl-1-phenyl-2-pyrazolin-5-one).This study aimed to compare neuroprotective effects of plus therapeutic (TH + EV) with those TH alone after insult in newborn piglet. Anaesthetized piglets were subjected 40 min hypoxia (3-5% inspired oxygen), and cerebral ischaemia was assessed using blood volume. Body temperature maintained...
It is important that blood glucose concentrations be accurately and conveniently measured in infants. However, especially the early neonatal period, point-of-care testing devices used for adults may not measure neonates.
<title>Abstract</title> Background Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn’s disease, are chronic disorders relating to gut microbiota dysbiosis. Despite severe pancolitis being more prevalent in pediatric UC than adult cases, alterations the colon mucosa-associated (MAM) their association with disease severity remain be elucidated. The present study aimed compare lavage fluids (CLFs) fecal samples from patients. Results A total of 140 CLFs 23 19 each...
Abstract There have been a number of recent reports on the occurrence autoimmune conditions after autologous hematopoietic stem cell transplantation. We describe rare case Evans syndrome ( ES ) that developed in 16‐year‐old patient >1 year peripheral blood transplantation for recurrent Hodgkin lymphoma. is and frequently refractory condition. No therapy condition has established, it can often be fatal. In present case, i.v. cyclosporine A injection was significantly effective against ,...
Efficacy of the over-the-scope clip (OTSC; Ovesco Endoscopy GmbH, Tübingen, Germany) system has been described in adult population [1] [2] [3] [4], very rarely pediatric patients. Wright et al. reported a first-ever application OTSC for patients weighing over 10 kg with gastrocutaneous fistula [5]. However, its indication younger patients, those lower weight, or other situations, such as refractory bleeding, remains unclear. Here, we describe effective temporary hemostasis massive duodenal...
A 10-year-old boy was referred to our hospital because of a 1-month history protein-losing gastroenteropathy with persistent vomiting, 4-year anemia and diarrhea, 3-year hypoalbuminemia. Stool antigen testing for Helicobacter pylori negative. Laboratory examination on admission showed low white blood cell count (4100/μL) eosinophils (164/μL) high immunoglobulin E (1793 IU/mL). Esophagogastroduodenoscopy revealed multiple reddish polypoid lesions mucus at the pylorus (Fig. 1A). Capsule...
Abstract Gaucher disease, the most common lysosomal storage is sometimes complicated with gastroesophageal reflux disease (GERD). The present patient was a 136‐day‐old Japanese boy type 2. Enzyme replacement therapy and chemical chaperone were successful for skin disorders, joint contractures, hepatosplenomegaly thrombocytopenia, but he also had GERD. Accordingly, Nissen fundoplication gastrostomy performed. There no vulnerability of organs, easy bleeding or difficulty maintaining visual...
Abstract We previously reported the neuroprotective potential of combined hydrogen (H 2 ) gas ventilation therapy and therapeutic hypothermia (TH) by assessing short-term neurological outcomes histological findings 5-day neonatal hypoxic-ischemic (HI) encephalopathy piglets. However, effects H on cerebral circulation oxygen metabolism prognosis were unknown. Here, we used near-infrared time-resolved spectroscopy to compare between TH alone. Piglets divided into three groups: HI insult with...