A5090024894- Neonatal and fetal brain pathology
- Infant Development and Preterm Care
- Neuroscience of respiration and sleep
- Optical Imaging and Spectroscopy Techniques
- Non-Invasive Vital Sign Monitoring
- Hydrogen's biological and therapeutic effects
- Neonatal Respiratory Health Research
- Neurogenetic and Muscular Disorders Research
- Genetics and Neurodevelopmental Disorders
- Family and Disability Support Research
- Congenital Anomalies and Fetal Surgery
- Cerebrospinal fluid and hydrocephalus
- Thermal Regulation in Medicine
- Infant Health and Development
- Neonatal Health and Biochemistry
- Infant Nutrition and Health
- Viral Infections and Immunology Research
- Neurosurgical Procedures and Complications
- Child Nutrition and Feeding Issues
- RNA modifications and cancer
- Child and Animal Learning Development
- Traumatic Brain Injury and Neurovascular Disturbances
- Autoimmune Neurological Disorders and Treatments
- Gaze Tracking and Assistive Technology
- Glycogen Storage Diseases and Myoclonus
Kagawa University
2016-2025
Kagawa University Hospital
2018
Acute flaccid myelitis (AFM) is an acute paralysis syndrome with spinal motor neuron involvement of unknown etiology. We investigated the characteristics and prognostic factors AFM clusters coincident enterovirus D68 (EV-D68) outbreak in Japan during autumn 2015.
Acute kidney injury (AKI) has been reported to occur in 30–70% of asphyxiated neonates. Hydrogen (H2) gas became a major research focus neonatal medicine after the identification its robust antioxidative properties. However, ability H2 ameliorate AKI is unknown. We examined histopathological injuries piglet renal cortex on day 5 hypoxic-ischemic (HI) insult and if can alleviate injuries. Twenty piglets were divided into three groups: no (Control, n = 6), HI alone (HI, 8), with ventilation...
Abstract This study aimed to evaluate the ethnic difference in fetal behavior between Asian and Caucasian populations. Fetal was assesed by Kurjak’s antenatal neurodevelopmental test (KANET) using four-dimensional (4D) ultrasound 28 38 weeks of gestation. Eighty-nine Japanese (representative Asians) seventy-eight Croatian Caucasians) pregnant women were studied. The total value KANET score values each parameter (eight parameters) compared. normal both populations, but there a significant...
We previously reported the neuroprotective potential of combined hydrogen (H
Anemia of prematurity commonly occurs in infants with very low birth weight; blood transfusion is an important treatment. However, there no clear evidence to support the criteria currently widely used, based on hemoglobin (bHb) and hematocrit indices. Previous studies showed that overtransfusion or a threshold for could induce complications neurologic sequelae, respectively. We hypothesized cerebral hemodynamic index may provide appropriate criterion determining need anemic preterm...
Abstract Therapeutic drug monitoring is generally unnecessary in caffeine treatment for apnea of prematurity, as serum concentrations preterm infants are normally markedly lower than those at which intoxication occurs. However, several studies have reported having developed toxicity. This retrospective observational study, conducted a tertiary center Kagawa, Japan, aimed to evaluate the correlation between maintenance dose and determine leading suggested toxic levels. We included 24...
The body temperature of infants at equilibrium with their surroundings is balanced between heat production from metabolism and the transfer to environment. Total related size, which closely metabolic rate oxygen consumption. Body control a crucial aspect neonatal medicine but we have often struggled measures. Contactless infrared thermography (IRT) useful for vulnerable neonates may be able assess spontaneous thermal metabolism. present study focused on oscillations cause. IRT was used...
Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in newborns both high- low-income countries. The important determinants its pathophysiology are neural cells vascular components. In neonatal HIE, increased permeability due to damage the blood-brain barrier associated with seizures poor outcomes translational clinical studies. our previous studies, hydrogen gas (H2) improved neurological outcome HIE ameliorated cell death. this study, we used albumin...
The aim of this study was to use near-infrared time-resolved spectroscopy (TRS) determine the absolute values cerebral blood volume (CBV) and hemoglobin oxygen saturation (ScO2) during immediate transition period in term neonates changes optical properties such as differential pathlength factor (DPF) reduced scattering coefficient (μs’). CBV ScO2 were measured using TRS first 15 min after birth by vaginal delivery who did not need resuscitation. Within 2–3 birth, showed various increases or...
Abstract Background The Japanese government has established a law encouraging early detection and treatment of developmental disorders in children. Child behavior problems ( CBP ) tend to be recognized at school as result disorders. aim this study was identify factors associated with Japan. We hypothesized that other than are important explaining . Methods conducted between February March 2015. Parents 3,515 children aged 2–5 years attending one 34 public nursery schools Takamatsu, Kagawa,...
Sporadic hemiplegic migraine is rare in childhood. We followed a patient with 99mTc-ECD (99mTc-ethyl cysteinate dimer) SPECT and magnetic resonance angiography (MRA). At the age of 8 years, he developed left hemiplegia. The MRA showed vasoconstriction posterior right middle cerebral artery. Hemiplegia disappeared few hours, normalized. 10 hemiplegia was observed, disappearing completely after days. During this second attack, demonstrated artery vasoconstriction, revealed decreased hemisphere...
Perinatal hypoxic-ischemic brain injury of neonates remains a significant problem worldwide. During the resuscitation period, changes in cerebral hemoglobin oxygen saturation (ScO2) have been identified by near-infrared spectroscopy (NIRS). However, asphyxiated neonates, relationship between these and is not known. Three-wavelength time-resolved spectroscopy, an advanced technology for NIRS, allows estimation ScO2 blood volume (CBV). Here, we studied CBV during period after insult...
The authors declare no conflict of interest.
Objective: Colostrum, the first form of human milk, is strongly encouraged for infants due to its benefits. During early postpartum (PP) period, secreted colostrum volume can be minimal, causing concerns among mothers about sufficient milk supply. Few studies have examined temporal changes in colostrum. This study aimed elucidate trajectory expressed 48 hours after delivery. Materials and Methods: was a cross-sectional observational performed at Kagawa National Children's Hospital. One...
It is important that blood glucose concentrations be accurately and conveniently measured in infants. However, especially the early neonatal period, point-of-care testing devices used for adults may not measure neonates.