A5028962718- Neonatal and fetal brain pathology
- Epilepsy research and treatment
- Infectious Encephalopathies and Encephalitis
- Neonatal Respiratory Health Research
- Metabolism and Genetic Disorders
- Pharmacological Effects and Toxicity Studies
- Viral Infections and Immunology Research
- Infant Development and Preterm Care
- Bacterial Infections and Vaccines
- Fetal and Pediatric Neurological Disorders
- Neonatal Health and Biochemistry
- EEG and Brain-Computer Interfaces
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Cytomegalovirus and herpesvirus research
- Genomic variations and chromosomal abnormalities
- RNA regulation and disease
- Long-Term Effects of COVID-19
- Genomics and Rare Diseases
- Kawasaki Disease and Coronary Complications
- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
Aichi Medical University
2016-2025
Aichi Medical University Hospital
2017-2023
Japan Pediatric Society
2020-2021
Tokyo Metropolitan Institute of Medical Science
2021
Tokyo Women's Medical University
2021
Tokyo Metropolitan Neurological Hospital
2021
Tokyo Women's Medical University Yachiyo Medical Center
2021
Kurashiki Central Hospital
2000-2020
Sakakibara Hospital
2019
Juntendo University
2009-2018
Recently, COL4A1 mutations have been reported in porencephaly and other cerebral vascular diseases, often associated with ocular, renal, muscular features. In this study, we aimed to clarify the phenotypic spectrum incidence of mutations.We screened for 61 patients 10 schizencephaly, which may be similarly caused by disturbed supply leading degeneration, but can distinguished depending on time insult.COL4A1 were identified 15 (21%, 5 schizencephaly), who showed a variety findings, including...
Acute flaccid myelitis (AFM) is an acute paralysis syndrome with spinal motor neuron involvement of unknown etiology. We investigated the characteristics and prognostic factors AFM clusters coincident enterovirus D68 (EV-D68) outbreak in Japan during autumn 2015.
To clarify whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection cause encephalopathy in children and which are the most common syndromes that them what outcomes.A nationwide web-based survey among all members of Japanese Society Child Neurology to identify pediatric patients aged < 18 years who developed Japan between 1 January 2020 31 May 2022 associated with confirmed by polymerase chain reaction or antigen tests using pharyngeal swabs. Acute was defined as onset...
Objective. The aim of this study was to elucidate the relationship between mechanical ventilation and hypocarbia in infants with periventricular leukomalacia (PVL). Study Design. Matched pair analysis conducted for 26 PVL normal development, who were born 27 32 weeks' gestational age required ventilation. time-averaged carbon dioxide (CO2) index, Paco2, pH calculated every 24 hours samples obtained from indwelling arterial catheters within first 72 life. respiratory rate ventilator (RR),...
Eight necropsy cases of a “panencephalopathic” type Creutzfeldt-Jakob disease (CJD) in the Japanese are reported. The reasons why this should be discussed separately from other types CJD that there is primary involvement cerebral white matter as well cortex, and lesion one human brain with similar to present group has been successfully transmitted experimental animals.
We sought to clarify the features of kernicterus in preterm infants.The subjects this study were 8 infants with athetoid cerebral palsy whose gestational ages < or =34 weeks. retrospectively investigated clinical, laboratory, MRI, and brainstem auditory evoked potential (BAEP) findings.Gestational age was =26 weeks 6 infants, birth weight <1000 g 5 infants. Serious postnatal complications systemic deterioration observed 3 Total bilirubin levels measured frequently majority infants; peak...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sometimes triggers encephalopathy as a serious neurological complication in children. We previously reported the clinico-radiological findings of SARS-CoV-2-associated encephalopathy. The advent SARS-CoV-2 omicron variant led to marked increase pediatric patients with disease 2019 (COVID-19); however, epidemiological changes according emergence have not yet been documented. Therefore, present study investigated differences during...
We conducted a phase I pharmacokinetic dose escalation study of recombinant humanized anti-p185HER2 monoclonal antibody (MKC-454) in 18 patients with metastatic breast cancer refractory to chemotherapy. Three or six at each level received 1, 2, 4 and 8 mg kg–1 MKC-454 as 90-min intravenous infusions. The first was followed 3 weeks by nine weekly doses. Target trough serum concentration has been set 10 μg ml–1 based on vitro observations. mean value minimum concentrations were 3.58 ± 0.63,...
To clarify the features of background electroencephalographic (EEG) activities in clinically well preterm infants born at less than 27 weeks gestation and to outline their chronological changes with increasing postconceptional age (PCA).EEGs premature were recorded during early postnatal period. The separated into three groups according PCA time EEG recording (21-22 PCA, 23-24 25-26 PCA). mean maximum duration interburst intervals (IBIs), bursts, percentage continuous discontinuous patterns...
Genetic mutations of the cyclin-dependent kinase-like 5 gene (CDKL5) have been reported in patients with epileptic encephalopathy, which is characterized by intractable seizures and severe-to-profound developmental delay. We investigated clinical relevance CDKL5 alterations both genders.A total 125 encephalopathy were examined for genomic copy number aberrations, 119 no such aberrations further mutations. Five Rett syndrome, who did not show methyl CpG-binding protein 2 (MECP2) mutations,...
Summary Purpose: The occurrence of acute encephalopathy in children with Dravet syndrome has been reported sporadically. This study clarified the features syndrome. Methods: Through mailing list Annual Zao Conference on Pediatric Neurology, we collected 15 patients clinically diagnosed syndrome, who had encephalopathy, defined as a condition decreased consciousness or without other neurologic symptoms, such seizures, lasting for >24 h association infectious symptoms. Key Findings: There...
OBJECTIVE: To clarify the prognostic value of conventional EEG for identification preterm infants at risk subsequent adverse neurodevelopment in current perinatal care and medicine setting. METHODS: We studied 780 records 333 born &lt;34 weeks’ gestation between 2002 2008. Serial recordings were conducted during 3 time periods; least once each within days 6 (first period), 7 to 19 (second 20 36 (third period). The presence grade background abnormalities assessed according an established...
CASE REPORT A previously healthy 13-year-old adolescent girl presented to our hospital after ingesting 2 neodymium magnets. Gastrointestinal injury was suspected; hence, abdominal radiograph performed assess the location of magnets and complications due foreign body. Radiograph revealed located separately in ascending colon (Figure 1). The following day, were found be attached on 1), we attempted their removal by colonoscopy.Figure 1.: (A) X-rays immediately patient arrived at showed...