A5068311071- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neonatal and fetal brain pathology
- Metabolism and Genetic Disorders
- Infectious Encephalopathies and Encephalitis
- Neuroscience and Neuropharmacology Research
- Fetal and Pediatric Neurological Disorders
- Mitochondrial Function and Pathology
- Bacterial Infections and Vaccines
- RNA regulation and disease
- Cytomegalovirus and herpesvirus research
- Pharmaceutical studies and practices
- Tuberous Sclerosis Complex Research
- Craniofacial Disorders and Treatments
- Ion channel regulation and function
- Vestibular and auditory disorders
- Viral Infections and Immunology Research
- Genetic Neurodegenerative Diseases
- Ophthalmology and Eye Disorders
- Sympathectomy and Hyperhidrosis Treatments
- Botulinum Toxin and Related Neurological Disorders
- Blood disorders and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Congenital heart defects research
- Neutropenia and Cancer Infections
Kitasato University
2019-2025
Saitama Children's Medical Center
2013-2024
King's College Hospital NHS Foundation Trust
2024
Imaging Center
2021
Kyoto University
2012-2018
Health and Human Development (2HD) Research Network
2006-2011
Toho University
1994-2009
Jikei University School of Medicine
2003-2006
Kanagawa Prefectural Hospital Organization
2004
Kanagawa Cancer Center
2004
Abstract Background There are many types of therapies for cancer. In these days, immunotherapies, especially immune checkpoint inhibitors, focused on. Though inhibitors there, the difference effect and its mechanism unclear. Some reports suggest response rate anti-PD-1 antibody is superior to that anti-PD-L1 could potentially produce different mechanisms action. On other hand, Treg also express PD-1; however, their relationship remains Methods this study, we used osteosarcoma cell lines in...
Summary Purpose: The occurrence of acute encephalopathy in children with Dravet syndrome has been reported sporadically. This study clarified the features syndrome. Methods: Through mailing list Annual Zao Conference on Pediatric Neurology, we collected 15 patients clinically diagnosed syndrome, who had encephalopathy, defined as a condition decreased consciousness or without other neurologic symptoms, such seizures, lasting for >24 h association infectious symptoms. Key Findings: There...
Autophagy is a recycling system for amino acids and carbon- nitrogen (N)-containing compounds. To date, the functional importance of autophagy in microalgae nutrient-deficient conditions has not been evaluated by using autophagy-defective mutants. Here, we provide evidence which supports following notions characterizing an insertional mutant autophagy-related gene ATG8, encoding ubiquitin-like protein necessary formation autophagosome green alga, Chlamydomonas reinhardtii. First, ATG8...
<title>Abstract</title> EFA6A is a guanine nucleotide exchange factor for ADP ribosylation 6 (Arf6), small GTPase involved in membrane trafficking and actin cytoskeleton remodeling. While EFA6A-Arf6 signaling has been shown to regulate dendritic spine formation maintenance cultured neurons, its role higher brain functions remains unclear <italic>in vivo</italic>. Here, we generated mice lacking two splicing isoforms, EFA6As, examine their regulating morphology hippocampus-dependent learning...
Patients with pathogenic cyclin-dependent kinase-like-5 gene (CDKL5) variants are designated CDKL5 deficiency disorder (CDD). This study aimed to delineate the clinical characteristics of Japanese patients CDD and elucidate possible appropriate treatments.We recruited or likely from a cohort approximately 1,100 developmental epileptic encephalopathies, who underwent genetic analysis. We retrospectively reviewed clinical, electroencephalogram, neuroimaging, information.We identified 29 (21...
The clinical efficacy of lidocaine for convulsive status epilepticus in 53 episodes was examined 37 children (17 males, 20 females). Mean age patients receiving 3 years 7 months (SD 3y 5mo). Lidocaine administration achieved control 19 (35.8%). Seizures ceased within 5 minutes all who were responsive to the drug. Regarding aetiology and types seizures, there no statistical difference effectiveness. Mild decrease oxygen saturation, monitored by pulse oximetry, observed one patient, which...
To determine the recommended phase II dose of vinorelbine in combination with cisplatin and thoracic radiotherapy (TRT) patients unresectable stage III non‐small cell lung cancer (NSCLC), 18 received (80 μg/m 2 ) on day 1 (20 level 1, 25 2) days 8 every 4 weeks for cycles. TRT consisted a single Gy once daily 3 followed by rest days, then same to total 60 Gy. Fifteen (83%) 14 (78%) cycles chemotherapy. Ten (77%) 13 at all 5 developed grade 3‐4 neutro‐penia. Four (31%) (60%) infection. None...
We previously performed genetic analysis in six unrelated families with infantile limb pain episodes, characterized by cold-induced deterioration and mitigation adolescence, reported two new mutations p.R222H/S SCN11A responsible for these episodes. As no term described this syndrome (familial episodic pain: FEP) Japanese, we named it as"小児四肢疼痛発作症". In the current study, recruited an additional 42 Japanese FEP families, between March 2016 2018, identified a total of 11 SCN11A: p.R222H seven...
The x-ray flat panel detector (FPD) is a key component of the next generation imaging systems which promote digitization images. By developing FPD applicable to both fluoroscopy and radiography, it expected that diagnostic will change dramatically not only in terms performance, but also shape form. purpose this research develop selenium-based radiography fluoroscopy. This report presents results work on new technology can be applied create clinically-useful view size detector. prototype...
Familial episodic pain syndrome (FEPS) is an early childhood onset disorder of severe limb caused mainly by pathogenic variants
Abstract Background Deafness, dystonia, and cerebral hypomyelination (DDCH) is an X‐linked disorder due to hemizygous mutations of BCAP31 . Methods We report 8‐year‐old boy with DDCH who possibly accompanied mitochondrial dysfunction. Clinical evaluation, respiratory chain enzyme assay, whole exome sequencing analysis were performed. Results Mitochondrial dysfunction was suspected by assay on his cultured skin fibroblasts which showed significantly decreased complex I activity. Whole...
Previously, we revealed that p58, one of the ascidian maternal factors, is identical to alpha-subunit F1-ATP synthase (ATPα), a protein complex inner mitochondrial membrane. In current study, used immunological probes for mitochondria components show ATPα ectopically localized cytosol. Virtually all were mitochondria-rich myoplasm. However, in detail, ATP subunits and matrix proteins showed different localization patterns. At least at crescent stage, transmission electron microscopy (TEM)...
Summary: Purpose: To elucidate the relation between alterations of regional cerebral blood flow (rCBF) by adrenocorticotropic hormone (ACTH) therapy and developmental outcomes cryptogenic West syndrome. Methods: Quantitative measurement rCBF, with autoradiography method using N‐isopropyl‐( 123 I) p‐iodoamphetamine single photon emission computed tomography before after ACTH therapy, was performed on 17 infants Regions interest for rCBF were placed bilaterally in cerebellum, thalamus, caudate...