A5081848146- Aerodynamics and Fluid Dynamics Research
- Cancer Immunotherapy and Biomarkers
- Knee injuries and reconstruction techniques
- Orthopaedic implants and arthroplasty
- Fluid Dynamics and Vibration Analysis
- Graphene and Nanomaterials Applications
- Total Knee Arthroplasty Outcomes
- Bone Tissue Engineering Materials
- Sports injuries and prevention
- Immune Cell Function and Interaction
- Nanoparticles: synthesis and applications
- Hip disorders and treatments
- Sarcoma Diagnosis and Treatment
- Immune cells in cancer
- Engineering Applied Research
- Pelvic and Acetabular Injuries
- Tendon Structure and Treatment
- Orthopedic Surgery and Rehabilitation
- Hip and Femur Fractures
- Monoclonal and Polyclonal Antibodies Research
- Railway Engineering and Dynamics
- CAR-T cell therapy research
- Computational Fluid Dynamics and Aerodynamics
- Fluid Dynamics and Turbulent Flows
- Railway Systems and Energy Efficiency
Shinshu University
2008-2024
Columbia University
2022-2024
Ōtani University
2007-2020
Shinshu University Hospital
2016
Kameda Medical Center
2014
National Hospital Organization
2013
Railway Technical Research Institute
2004-2008
Tohoku University
2008
Tokai University
2005-2006
Oita University
2005
Abstract Titanium plates are widely used in clinical settings because of their high bone affinity. However, owing to elastic modulus, these not suitable for repair since proximity the surface prolonged periods can cause stress shielding, leading embrittlement. In contrast, titanium fiber prepared by molding fibers into simultaneously applying compression and shear at normal room temperature have an modulus similar that cortex, shielding will occur even when plate lies flush against bone's...
Abstract Background There are many types of therapies for cancer. In these days, immunotherapies, especially immune checkpoint inhibitors, focused on. Though inhibitors there, the difference effect and its mechanism unclear. Some reports suggest response rate anti-PD-1 antibody is superior to that anti-PD-L1 could potentially produce different mechanisms action. On other hand, Treg also express PD-1; however, their relationship remains Methods this study, we used osteosarcoma cell lines in...
The Short Form 36, Toronto Extremity Salvage Score, and the 1987 1993 Musculoskeletal Tumor Society Rating Scales were compared as measures of functional status for patients with lower extremity sarcoma. study included 97 sarcoma evaluated each measure on following measurement properties: conceptual framework; statement purpose; feasibility; breadth content; depth measurement; cross sectional longitudinal reliability; validity responsiveness. 36 represents patients' perceptions their...
Summary Background IL‐13 induces goblet cell hyperplasia and mucus overproduction in airway epithelial cells. receptor α2 (IL‐13Rα 2 ) has been suggested to act as a ‘decoy receptor’ the epithelium by inhibiting signal. However, regulatory mechanisms for production IL‐13Rα remain unclear. Objective The aim of this study was examine role IL‐13. Methods Bronchi were obtained from patients who underwent lung resection due cancer or benign tumours. Normal human bronchial cells (NHBECs) isolated...
Carbon nanotubes (CNTs) have attracted a great deal of attention for the biological and medical science fields because their characteristic physical properties. In this study, we investigated capacity 3D porous CNT scaffold (CNT block; CNTp) bone regenerative medicine. Surface observations using scanning electron microscope (SEM), crystal depositions on surface CNTps immersed in simulated body fluid (SBF), evaluations protein adsorption controlled releasing were conducted to assess The cell...
Two main concerns with pantographs used on high speed trains have been their aerodynamic stability and aeroacoustic noise reduction. These properties depend the shape of pantograph, but these is often a trade-off between them pantograph design therefore very delicate process. As many wind tunnel tests are required before an adequate found, process time-consuming expensive. To improve efficiency new-type development, new including computational fluid dynamics (CFD) optimization techniques was...
The unidirectional porous hydroxyapatite HAp (UDPHAp) is a scaffold with continuous communicated pore structure in the axial direction. We evaluated and compared ability of UDPHAp as three-dimensional (3D) bone tissue engineering to interconnected calcium ceramic (IP-CHA). To achieve this, we vitro compressive strength, controlled rhBMP-2 release behavior, adherent cell morphology, adhesion manner, attachment UDPHAp. As further vivo experiment, IP-CHA were transplanted into mouse calvarial...
Purpose: Although both anti-PD-1 antibody and treatments using anti-PD-L1 are currently in clinical use, their therapeutic effects vary according to cancer type.One of the factors accounting for this variability is expression level immune checkpoint molecule that differs between types; thus, it important clarify relationship outcomes molecules all types human cancer.The purpose study evaluate outcome osteosarcoma relation PD-L1, PRF, GZMB, IFNγ expression.Methods: Using 19 specimens...
The caption of Fig. 6 should read as follows. (a) and (b) Time course mRNA expression MUC5AC IL-13Rα2 in normal human bronchial epithelial cells cultured with IL-13 (10 ng/mL). results are the mean±SEM from 14 different bronchi. Significant differences values on day 0 indicated by *P<0.05, **P<0.02, ***P<0.005. text citation No only a small amount were observed before adding (day 0) (Figs 6a b). significantly increased days to 7 after treatment ng/mL), returned baseline levels at 21 (Fig....
<b><i>Background:</i></b> Muscle pathology is often unhelpful in elucidating the specific underlying abnormality patients with metabolic myopathy rhabdomyolysis, including very-long chain acyl-CoA dehydrogenase (VLCAD) deficiency. Biochemical analyses require large amounts of biopsy samples for each enzyme assay. <b><i>Objective:</i></b> To develop a more efficient diagnostic method VLCAD <b><i>Methods:</i></b> The authors performed immunohistochemical analysis using an antibody to on...
In monkey coronary artery strips contracted with prostaglandin (PG) F2 alpha or K+, exchange of entire N2 for O2 in the gas aerating bathing media produced a contraction. Endothelium denudation did not alter response. Aspirin, indomethacin, and ONO 3708, PG receptor antagonist, markedly inhibited hypoxia-induced contraction, whereas superoxide dismutase OKY 046, thromboxane (Tx) A2 synthesis inhibitor, were ineffective. Diltiazem depressed Hypoxia increased release PGE2 but 6-keto-PGF1 TxB2....
To modify aerodynamic characteristics of pantographs for high-speed trains, we propose to blow air from the surface a panhead. The outlets blowing are bored in rows near trailing edge estimate effect blowing, first conduct wind tunnel test using two-dimensional panhead model. results reveal that pressure distribution on model can be changed by blowing. Then examine full-scale pantograph prove proposed method has great potential practical applications.
A new design technique for panheads of pantographs used on high-speed trains was proposed to take much the load off wind tunnel experiments development pantograph. The with emphasis reduction computational costs determines cross-sectional panhead shape numerically, which balances low-level aeroacoustic noise property stable lift force characteristics. An examplary designed by this examined experiments. test results successfully demonstrated capabilities method.
We report a case of carcinosarcoma the parotid gland in 72‐year‐old Japanese man. The patient noticed rapidly enlarging hard mass right gland. He underwent radical parotidectomy with cervical lymph node dissection. resected tumor measured 3.5×4.5 cm and histopathologically showed carcinomatous sarcomatous components. component consisted large‐cell neuroendocrine carcinoma (LCNEC), squamous cell adenocarcinoma not otherwise specified, while included spindle sarcoma so‐called myxosarcoma...
Introduction: Carbon nanotubes (CNTs) have various shapes, including needle-like shapes and curled the cytotoxicity carcinogenicity of CNTs differ depending on their surface modifications. However, biological responses induced by related mechanisms according to dispersion state not been extensively studied. Materials methods: We prepared multiwalled (MWCNTs) showing different dispersions evaluated these MWCNTs in RAW264 cells determine cytotoxicity, cellular uptake, immune responses....
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has affected approximately 800 million people since the start of Disease 2019 (COVID-19) pandemic. Because high rate mutagenesis in SARS-CoV-2, it is difficult to develop a sustainable approach for prevention and treatment. The Envelope (E) protein highly conserved among human coronaviruses. Previous studies reported that SARS-CoV-1 E deficiency reduced viral propagation, suggesting inhibition might be an effective therapeutic...
The current report presents the case of a 41-year-old male exhibiting giant cell tumor tendon sheath (GCT-TS) arising from patellar sheath. Plain radiography and magnetic resonance imaging revealed well-localized mass that wrapped around tendon, extended subcutis into infrapatellar fat pad tibia. Following histopathological determination diagnosis, piecemeal resection was performed. Nodular-type GCT-TS occurs less frequently in large joints compared with small fingers toes. unique features...
Various risk factors and causative genes of osteosarcoma have been reported in the literature; however, its etiology remains largely unknown. Bone formation is a shared phenomenon all types osteosarcomas, sclerostin an extracellular soluble factor secreted by osteocytes that prevents bone inhibiting Wnt signaling pathway. We aimed to investigate antitumor effect against osteosarcoma. Osteosarcoma model mice were prepared transplantation into dorsal region C3H/He BALB/c-nu/nu using cell lines...