A5012564588- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Orthopaedic implants and arthroplasty
- Nanoparticles: synthesis and applications
- Cancer Immunotherapy and Biomarkers
- Carbon Nanotubes in Composites
- Immune Cell Function and Interaction
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- Graphene research and applications
- Diamond and Carbon-based Materials Research
- Cancer Cells and Metastasis
- Vacuum and Plasma Arcs
- Anesthesia and Neurotoxicity Research
- Cellular transport and secretion
- Dental Implant Techniques and Outcomes
- Calcium Carbonate Crystallization and Inhibition
- Hip and Femur Fractures
- Electrohydrodynamics and Fluid Dynamics
- Orthopedic Infections and Treatments
- Advanced Sensor Technologies Research
- Bone health and osteoporosis research
- Bone and Dental Protein Studies
- Boron Compounds in Chemistry
- 3D Printing in Biomedical Research
Yamato Municipal Hospital
2020-2024
City Hospital
2020
Nagano University
2020
Shinshu University
2014-2020
Ōtani University
2015-2020
Abstract Titanium plates are widely used in clinical settings because of their high bone affinity. However, owing to elastic modulus, these not suitable for repair since proximity the surface prolonged periods can cause stress shielding, leading embrittlement. In contrast, titanium fiber prepared by molding fibers into simultaneously applying compression and shear at normal room temperature have an modulus similar that cortex, shielding will occur even when plate lies flush against bone's...
Bronchial epithelial cells and mesothelial are crucial targets for the safety assessment of inhalation carbon nanotubes (CNTs), which resemble asbestos particles in shape. Intrinsic properties multiwalled CNTs (MWCNTs) known to cause potentially hazardous effects on intracellular extracellular pathways. These interactions alter cellular signaling affect major cell functions, resulting death, lysosome injury, reactive oxygen species production, apoptosis, cytokine release. Furthermore,...
Carbon nanotubes (CNTs) have attracted a great deal of attention for the biological and medical science fields because their characteristic physical properties. In this study, we investigated capacity 3D porous CNT scaffold (CNT block; CNTp) bone regenerative medicine. Surface observations using scanning electron microscope (SEM), crystal depositions on surface CNTps immersed in simulated body fluid (SBF), evaluations protein adsorption controlled releasing were conducted to assess The cell...
Abstract: This study aimed to investigate the influence of shape and size multi-walled carbon nanotubes (MWCNTs) cup-stacked (CSCNTs) on biological responses in vitro. Three types MWCNTs – VGCF ® -X, -S, (vapor grown fibers; with diameters 15, 80, 150 nm, respectively) three CSCNTs different lengths (CS-L, 20–80 µm; CS-S, 0.5–20 CS-M, intermediate length) were tested. Human bronchial epithelial (BEAS-2B) malignant pleural mesothelioma cells exposed CNTs (1–50 µg/mL), cell viability,...
The unidirectional porous hydroxyapatite HAp (UDPHAp) is a scaffold with continuous communicated pore structure in the axial direction. We evaluated and compared ability of UDPHAp as three-dimensional (3D) bone tissue engineering to interconnected calcium ceramic (IP-CHA). To achieve this, we vitro compressive strength, controlled rhBMP-2 release behavior, adherent cell morphology, adhesion manner, attachment UDPHAp. As further vivo experiment, IP-CHA were transplanted into mouse calvarial...
Many recent studies have been conducted to assess the ability of composite materials containing carbon nanotubes (CNTs) with high bone affinity serve as scaffolds in regenerative medicine. These demonstrated that CNTs can effectively induce formation. However, no investigated usefulness consisting exclusively We built a three-dimensional block entity maximized mechanical strength from multi-walled (MWCNT blocks) and evaluated their efficacy scaffold material for repair. When MWCNT blocks...
Because ultrahigh-molecular-weight polyethylene (UHMWPE) is susceptible to frictional wear when used in sliding members of artificial joints, it common practice use cross-linked UHMWPE instead. However, has low impact resistance; implant breakage been reported some cases. Hence, joints pose a major trade-off between resistance and resistance, which not resolved by any UHMWPE. On the other hand, multiwall carbon nanotubes (MWCNTs) are industrial products for reinforcement polymeric materials...
Abstract Biological evaluation of carbon nanotubes (CNTs) is typically performed in the lung or abdominal cavity; however, biological reactions to CNTs are predicted be markedly different other tissues. In applications as reinforcement for artificial joints and drug delivery systems, including their use bone regeneration, intra-articular synovial membrane makes contact with CNTs. Herein, we analyzed reaction multiwalled (MWCNTs). Injection MWCNTs into rat knee revealed dose-dependent...
The medical applications of carbon nanotubes (CNTs) have garnered much attention. However, evaluating the safety CNTs remains difficult, and no consensus has been reached. Moreover, assessing biosafety multi-walled (MWCNTs), which can become tangled during manufacturing, is challenging because they do not readily disperse. We studied how dispersion state MWCNTs affects their cytotoxicity, using three sonicators. Flotube 9110 (FT9110), MWCNTs, were dispersed in two dispersants (fetal bovine...
We evaluated starfish-derived β-tricalcium phosphate (Sf-TCP) obtained by phosphatization of starfish-bone-derived porous calcium carbonate as a potential bone substitute material. The Sf-TCP had communicating pore structure with size approximately 10 μm. Although the porosity was similar to that Cerasorb M (CM)-a commercially available β-TCP filler-the specific surface area roughly three times larger than CM. Observation scanning electron microscopy showed pores communicated inside Sf-TCP....
The biosafety of carbon nanotubes (CNTs) is a concern, and CNT biokinetics key issue. CNTs labeled with isotopes, functionalized moieties, or coated colloidal metal particles have been used to monitor biokinetics, though major technical issues (such as isotope preparation handling change in surface properties) remain. present report aims at establishing an advanced simple situ imaging method monitoring vivo involving the use filled heavy (peapods). Gadolinium (Gd)-peapods containing GdCl3...
Purpose: Multiwalled carbon nanotubes (MWCNTs) have been known to enter the circulatory system via lungs from inhalation exposure; however, its carcinogenicity and subsequent accumulation in other organs not adequately reported literature. Moreover, safety of MWCNTs as a biomaterial has remained matter debate, particularly when material enters system. To address these problems, we used carcinogenic rasH2 transgenic mice intravenously administer highly dispersed evaluate their organs....
Local administration of cisplatin-conjugated carbon fibers is expected to become the first therapy suppress cancer growth with low prevalence adverse reactions, and repair bone damaged by metastasis.
Abstract Background: There are many types of therapies for cancer. In these days, immunotherapies, especially immune checkpoint inhibitors, focused on. Though inhibitors there, the difference effect and its mechanism unclear. Some reports suggest response rate anti-PD-1 antibody is superior to that anti-PD-L1 could potentially produce different mechanisms action. On other hand, Treg also express PD-1; however, their relationship remains Methods: this study, we used osteosarcoma cell lines in...
Abstract Background: There are many types of therapies for cancer. In these days, immunotherapies, especially immune checkpoint inhibitors, focused on. Though inhibitors there, the difference effect and its mechanism unclear. Some reports suggest response rate anti-PD-1 antibody is superior to that anti-PD-L1 could potentially produce different mechanisms action. On other hand, Treg also express PD-1; however, their relationship remains Methods: this study, we used osteosarcoma cell lines in...
Abstract Background: There are many types of therapies for cancer. In these days, immunotherapies, especially immune checkpoint inhibitors, focused on. Though inhibitors there, the difference effect and its mechanism unclear. Some reports suggest response rate anti-PD-1 antibody is superior to that anti-PD-L1 could potentially produce different mechanisms action. On other hand, Treg also express PD-1; however, their relationship remains Methods: this study, we used osteosarcoma cell lines in...
Abstract Background: There are many types of therapies for cancer. In these days, immunotherapies, especially immune checkpoint inhibitors, focused on. Though inhibitors there, the difference effect and its mechanism unclear. Some reports suggest response rate anti-PD-1 antibody is superior to that anti-PD-L1 could potentially produce different mechanisms action. On other hand, Treg also express PD-1; however, their relationship remains Methods: this study, we used osteosarcoma cell lines in...
Abstract Background: There are many types of therapies for cancer. In these days, immunotherapies, especially immune checkpoint inhibitors, focused on. Though inhibitors there, the difference effect and its mechanism unclear. Some reports suggest response rate anti-PD-1 antibody is superior to that anti-PD-L1 could potentially produce different mechanisms action. On other hand, Treg also express PD-1; however, their relationship remains Methods: this study, we used osteosarcoma cell lines in...