A5014526577- Infectious Encephalopathies and Encephalitis
- Bacterial Infections and Vaccines
- Viral Infections and Immunology Research
- Influenza Virus Research Studies
- RNA regulation and disease
- Epilepsy research and treatment
- Metabolism and Genetic Disorders
- Genetics and Neurodevelopmental Disorders
- Autoimmune Neurological Disorders and Treatments
- Respiratory viral infections research
- Mosquito-borne diseases and control
- Fetal and Pediatric Neurological Disorders
- Tryptophan and brain disorders
- Viral gastroenteritis research and epidemiology
- Shape Memory Alloy Transformations
- Congenital heart defects research
- Neonatal Respiratory Health Research
- Alcoholism and Thiamine Deficiency
- Neuroendocrine regulation and behavior
- Hedgehog Signaling Pathway Studies
- RNA and protein synthesis mechanisms
- Genomic variations and chromosomal abnormalities
- interferon and immune responses
- Nanocluster Synthesis and Applications
- Infant Development and Preterm Care
Tokyo Metropolitan Neurological Hospital
2009-2024
The University of Tokyo
2012-2023
University of Tokyo Hospital
2023
National Rehabilitation Center for Persons with Disabilities
2013
Yokohama National University
2012
Tokyo Metropolitan Children's Medical Center
2009-2011
Yahoo (United Kingdom)
2009
Tohoku University
1994
Isolation and characterization of cDNAs encoding human very low density lipoprotein (VLDL) receptor revealed the presence two forms receptor: one consists five domains that resemble (LDL) receptor, a variant form lacks an 0-linked sugar domain.More than 96% amino acids in rabbit VLDL receptors are identical, whereas those LDL less conserved between species (76%).The gene contains 19 exons spanning approximately 40 kilobases.The exon-intron organization is almost same as gene, except for...
Vagus nerve stimulation (VNS) is a palliative treatment for drug-resistant epilepsy (DRE) that has been in use over two decades. VNS suppresses epileptic seizures, prevents emotional disorders, and improves cognitive function sleep quality, parallel effect associated with the control of seizures. The seizure suppression rate increases monthly to annually, incidence side effects reduces time. This method effective treating DRE children as well adults, such tuberous sclerosis, Dravet syndrome,...
Abstract Most childhood cases of acute necrotizing encephalopathy ( ANE ) involve neither family history nor recurrence. occasionally occurs, however, as a familial disorder or recurs in Caucasian patients. A mutation RAN ‐binding protein 2 RANBP has been discovered more than one half recurrent In contrast, there no report this East Asia. Here, we the first sibling typical Japan, with poor outcome. DNA analysis genes associated other encephalopathies, including and carnitine palmitoyl...
Abstract Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a severe preceded by viral infections high fever. AESD multifactorial disease, however, few disease susceptibility genes have previously been identified. Here, we conducted genome-wide association study (GWAS) assessed functional variants in non-coding regions to genetic using 254 Japanese children 799 adult healthy controls. We also performed microRNA enrichment analysis GWAS statistics search for...
Acute necrotizing encephalopathy (ANE) is a severe complication of infectious diseases affecting the brain and systemic organs. The main pathogenesis cytokine storm, in which interleukin-6 (IL-6) interleukin-10 (IL-10) are candidates for key cytokines. To further elucidate their roles etiology ANE, we studied polymorphisms promotor regions IL6 IL10 genes by genetic functional analyses.We first conducted case-control association study four three polymorphisms. We genotyped 31 Japanese ANE...
This study was carried out to understand the disparities in mortality and survival without major morbidities among very premature low birth weight infants between participating Neonatal Intensive Care Units (NICUs) from Brazilian Network on Research (RBPN) of Japan (NRNJ).Secondary data analysis surveys by RBPN NRNJ performed. The were conducted 2014 2015 included 187 NICUs. Primary outcome or any morbidity. Logistic regression adjustment for confounding factors used.The population consisted...
Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a severe neurologic complication of febrile infectious diseases in children. At the onset, AESD clinically manifested as status epilepticus. Subsequent damage to cerebral cortex ascribed neurotoxicity. The incidence remarkably high Japan, suggesting involvement genetic factors. expression interleukin 1 beta (IL-1β), member cytokine family involved inflammatory response, reportedly associated rs16944,...