A5061749126- Infectious Encephalopathies and Encephalitis
- Epilepsy research and treatment
- Bacterial Infections and Vaccines
- Neonatal and fetal brain pathology
- Pharmacological Effects and Toxicity Studies
- Long-Term Effects of COVID-19
- Multiple Sclerosis Research Studies
- Metabolism and Genetic Disorders
- Viral Infections and Immunology Research
- Mitochondrial Function and Pathology
- Cytomegalovirus and herpesvirus research
- Peripheral Neuropathies and Disorders
- Neurological and metabolic disorders
- Viral gastroenteritis research and epidemiology
- Neurological diseases and metabolism
- Allergic Rhinitis and Sensitization
- Respiratory Support and Mechanisms
- Mesenchymal stem cell research
- Thermal Regulation in Medicine
- Autoimmune and Inflammatory Disorders Research
- Infant Development and Preterm Care
- Genetics and Neurodevelopmental Disorders
- Neonatal Respiratory Health Research
- Neonatal Health and Biochemistry
- Autoimmune Neurological Disorders and Treatments
Kobe University
2016-2025
Kobe Children's Hospital
2013-2025
Nagase (Japan)
2021
Kobe University Hospital
2017
Boston Children's Hospital
2014
Fukuoka University
2005-2006
Epidemiological studies in Kawasaki disease (KD) have suggested infectious aetiology. During the COVID-19 pandemic, measures for mitigating SARS-CoV-2 transmission also suppress circulation of other contagious microorganisms. The primary objective is to compare number and incidence KD before during pandemic Japan, secondary investigate temporal association between epidemiology activities viral bacterial infections.A retrospective cohort study was conducted 2016 2020 Kobe, Japan. We collected...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sometimes triggers encephalopathy as a serious neurological complication in children. We previously reported the clinico-radiological findings of SARS-CoV-2-associated encephalopathy. The advent SARS-CoV-2 omicron variant led to marked increase pediatric patients with disease 2019 (COVID-19); however, epidemiological changes according emergence have not yet been documented. Therefore, present study investigated differences during...
Only 2 cases of human adenovirus type 14 (HAdV-14) have been reported in Japan since 1980. We report a 7-year-old girl with acute encephalopathy associated HAdV-14 infection genetically similar to strains from the United States. The patient had not contact international travelers. surveillance should be strengthened Japan.
Abstract Purpose Status epilepticus associated with fever (SEF) is often encountered in pediatric emergency departments, and some patients develop neurological emergencies, such as acute encephalopathy (AE). Although numerous genetic variants of developmental epileptic (DEE) have been reported, the frequency these disease‐associated SEF unknown. The first aim this study was to investigate SEF. second compare variations genes between DEE. Method This retrospective, clinical observational...
ABSTRACT Systemic primary carnitine deficiency (SPCD) is a rare congenital fatty acid metabolism disorder causing impaired β‐oxidation and energy production, leading to hypoglycemia, metabolic encephalopathy, sudden death. Early diagnosis treatment, including L‐carnitine supplementation fasting avoidance, can improve prognosis. However, newborn screening (NBS) criteria differ by region, standardized guidelines are lacking. This report presents case of SPCD undetected NBS, resulting in basal...
Cytokine levels have been measured in acute encephalopathy (AE) to determine its pathology or as a diagnostic biomarker distinguish it from febrile seizures (FS); however, the dynamics of cytokine level changes not yet fully captured these two neurological manifestations. Thus, we aimed explore time course serum within 72 h after onset AE and FS.We retrospectively residual samples at multiple timepoints seven children whose final diagnoses were FS.The 13 cytokines appeared increase...
Glycosylphosphatidylinositol (GPI) anchors tether proteins to the extracellular face of eukaryotic plasma membranes. Defects in human GPI anchor biosynthetic pathway cause inherited deficiencies (IGDs) characterized by multiple congenital anomalies: dysmorphic faces, developmental delay, hypotonia, and epilepsy. We report case a 6‐year‐old boy with severe psychomotor epilepsy, decreased granulocyte surface expression GPI‐anchored protein that suggested autosomal recessive deficiency. The...
Abstract Background Wilson disease (WD) is an autosomal recessive disorder caused by mutations in the ATP7B gene. In 1984, Scheinberg and Sternlieb estimated prevalence of WD to be 1:30 000. However, recent epidemiological studies have reported increasing rates different populations. The carrier frequency variants Japanese population not been using multiple databases. Methods Multiple public databases were used. First, we included gene that registered Human Gene Mutation Database (HGMD)...
Abstract “Infantile spasms syndrome (IS),” previously known as “West (WS),” is characterized by epileptic (ES), abnormal electroencephalography (EEG) patterns such hypsarrhythmia, and developmental stagnation or regression in infancy. IS has various etiologies, including genetic abnormalities. SCN8A variants are associated with encephalopathy, delay, seizures starting from infancy, refractory epilepsy multiple seizure types. However, previous studies have not focused on the treatment of...
Mesenchymal stem cells (MSCs) have considerable therapeutic potential and attract increasing interest in the biomedical field. MSCs are originally isolated characterized from bone marrow (BM), then acquired tissues including adipose tissue, synovium, skin, dental pulp, fetal appendages such as placenta, umbilical cord blood (UCB), (UC). a heterogeneous cell population with capacity for (1) adherence to plastic standard culture conditions, (2) surface marker expression of...
Objective To investigate the prevalence of seizures/febrile seizures in children up to 3 years age and examine effects gestational at birth on risk for febrile seizures. Design Retrospective longitudinal population-based cohort study. Setting Kobe City public health center , Kobe, Japan, from 2010 2018. Participants Children who underwent a medical check-up age. Methods Information regarding was collected parents 96 014 children. We identified occurrence seizure/febrile seizure 74 017...