A5085242247- Epilepsy research and treatment
- Infectious Encephalopathies and Encephalitis
- Ion Channels and Receptors
- Pharmacological Effects and Toxicity Studies
- Neonatal and fetal brain pathology
- Bacterial Infections and Vaccines
- Glioma Diagnosis and Treatment
- Biochemical Analysis and Sensing Techniques
- Vestibular and auditory disorders
- Sarcoma Diagnosis and Treatment
- Asthma and respiratory diseases
- Glaucoma and retinal disorders
- Long-Term Effects of COVID-19
- Urinary Bladder and Prostate Research
- Neuroscience of respiration and sleep
- Soft tissue tumor case studies
- Neurobiology and Insect Physiology Research
- Tracheal and airway disorders
- Electrolyte and hormonal disorders
- Autoimmune Neurological Disorders and Treatments
- Chromatin Remodeling and Cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Multiple Sclerosis Research Studies
- Histone Deacetylase Inhibitors Research
- Cancer Treatment and Pharmacology
Fukuoka University
2023-2025
Kobe Children's Hospital
2016-2024
Otsu Municipal Hospital
2023
City Hospital
2023
Sapporo Higashi Tokushukai Hospital
2023
Sapporo Medical University
2023
Yahoo (United Kingdom)
2023
Wakkanai Hokusei Gakuen College
2023
Okayama University Hospital
2023
Hokkaido University
2002-2022
We studied the localization and physiological functions of transient receptor potential (TRP) channels TRPV1 (TRP vanilloid 1) TRPV4 4) in mouse bladder, because both are thought to be mechanosensors for bladder distention. RT-PCR specifically amplified transcripts from urothelial cells, whereas were barely detectable. ISH experiments showed that abundantly expressed urothelium, not detectable cells. Immunoblotting IHC studies proteins mainly localized at basal plasma membrane domains In...
The subtype 2 and 3 ionotropic purinergic receptors (P2X receptors) are crucial for gustation, but the distribution of these in geniculate ganglion (GG) their colocalization tongue papillae remain unknown. Here we investigated expression P2X(2) P2X(3) GG fungiform rats mice by using situ hybridization immunohistochemistry. In both species, transcripts immunoreactivity were detected approximately 50-60% neuronal somata, whereas those observed almost all neurons. each papilla, was mostly...
Adenosine triphosphate (ATP) is a signaling molecule that regulates cellular processes. Based on previous studies of bladder function over the past decade, ATP was thought to have an essential role in normal micturition reflex. In this study, we performed detailed analyses purinergic receptor-deficient mice using automated voided stain paper method and video-urodynamics. Unexpectedly, lack P2X2 or P2X3 receptors did not affect under physiological conditions, indicating for contrast, found...
This study aimed to evaluate the utility of extracellular volume (ECV) fraction for predicting wall-invasion patterns in advanced gallbladder carcinoma (GBCA). Patients who had surgically resected GBCA at a single institution were retrospectively evaluated. All patients underwent computed tomography (CT) before surgery. Based on pathological examinations, pattern was classified into two groups: infiltrative growth (IG, n = 19) and destructive (DG, 11). ECV map generated by inputting...
ABSTRACT Desmoplastic fibroblastoma (DF) is a rare fibrotic tumor that has wide anatomic distribution and it can appear in deep sections of the subcutis, fascia, aponeurosis or skeletal muscles. This report describes case DF appeared on left side neck 55‐year‐old male as 3.5‐cm solitary, firm nodule. Histologically, was composed stellate bland spindle‐shaped cells embedded loose collagenous stroma. The entrapment fat muscle tissues focally identified at edges tumor. multinucleated lesion...
The transient receptor potential vanilloid 4 (TRPV4), a thermo-sensitive stretch-activated cation channel, is expressed in the skin stratified squamous epithelium, contributing to acquisition of barrier function. Similarly, functional TRPV4 may be located epithelial lining esophagus, being involved pathogenesis gastroesophageal reflux disease (GERD). Here we investigated expression mouse esophageal epithelium.TRPV4 at mRNA and protein levels was examined by reverse transcription-polymerase...
Objective To investigate the prevalence of seizures/febrile seizures in children up to 3 years age and examine effects gestational at birth on risk for febrile seizures. Design Retrospective longitudinal population-based cohort study. Setting Kobe City public health center , Kobe, Japan, from 2010 2018. Participants Children who underwent a medical check-up age. Methods Information regarding was collected parents 96 014 children. We identified occurrence seizure/febrile seizure 74 017...