A5057450160- Urinary Bladder and Prostate Research
- Urinary Tract Infections Management
- Testicular diseases and treatments
- Urological Disorders and Treatments
- Sperm and Testicular Function
- Hormonal and reproductive studies
- Urologic and reproductive health conditions
- Pelvic floor disorders treatments
- Circadian rhythm and melatonin
- Prostate Cancer Diagnosis and Treatment
- Shape Memory Alloy Transformations
- Adrenal and Paraganglionic Tumors
- Genital Health and Disease
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Sarcoma Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Renin-Angiotensin System Studies
- Lanthanide and Transition Metal Complexes
- Sexuality, Behavior, and Technology
- Renal and Vascular Pathologies
- Neuroblastoma Research and Treatments
- Pituitary Gland Disorders and Treatments
- Microstructure and mechanical properties
- Nitric Oxide and Endothelin Effects
Osaka University
2016-2025
Utsunomiya University
2024
Japan Society for the Promotion of Science
2024
Jichi Medical University
2024
ORCID
2021
Osaka Prefectural Medical Center
2011-2018
Osaka City General Hospital
2011-2017
Osaka Police Hospital
2012-2013
Osaka Medical Center for Cancer and Cardiovascular Diseases
2009-2011
Hokkaido University
1975-1999
Abstract Background The pathophysiology of the prostate enlargement underlying lower urinary tract symptoms is unknown. Meanwhile, gut microbiota can contribute to various host conditions. We hypothesized that plays a role in enlargement. Methods included 128 patients who underwent biopsies at our hospitals between December 2018 and March 2020, excluding those had used antibiotics within past 6 months were diagnosed with cancer cT3 or higher. Patients volumes ≥30 ml defined as...
In males, testosterone levels have been implicated in various diseases. Recently, the influence of gut microbial-derived compounds on host metabolism has become evident, and it suggested that some bacteria may be involved metabolism. present study, we examined relationship between microbiota elderly Japanese men.
Adenosine triphosphate (ATP) is a signaling molecule that regulates cellular processes. Based on previous studies of bladder function over the past decade, ATP was thought to have an essential role in normal micturition reflex. In this study, we performed detailed analyses purinergic receptor-deficient mice using automated voided stain paper method and video-urodynamics. Unexpectedly, lack P2X2 or P2X3 receptors did not affect under physiological conditions, indicating for contrast, found...
Abstract Purpose The average fatherhood age has been consistently increasing in developed countries. Aging identified as a risk factor for male infertility. However, its impact on various mechanisms remains unclear. This study focused the KEAP1–NRF2 oxidative stress response system, by investigating relationship between system and age‐related changes spermatogenesis. Method s For examination of changes, we used 10‐, 30‐, 60‐, 90‐week‐old mice to compare sperm count, motility, protein...
Objectives Nocturnal polyuria (NP) is one of the causes nocturia that impairs quality life. It necessary to consider NP latent when initial treatment for unsatisfactory. Therefore, it important establish a based on pathophysiology. We have previously reported relationship between and fluctuation in blood pressure. The present study aimed investigate association 24‐h pressure fluctuations multicenter prospective study. Methods This included male patients with lower urinary tract symptoms....
Autophagy degrades unnecessary proteins or damaged organelles to maintain cellular function. Therefore, autophagy has a preventive role against various diseases including hepatic disorders, neurodegenerative diseases, and cancer. Although in germ cells Sertoli is known be required for spermatogenesis male fertility, it remains poorly understood how participates spermatogenesis. We found that systemic knockout mice of Rubicon , negative regulator autophagy, exhibited substantial reduction...
Various animal models have been used in research into bladder dysfunction, and vivo cystometry is a common method to analyze function animals. However, it rather difficult perform reliably small Transabdominal ultrasonography combined with urethane-anesthetized mice revealed physical inhibition of wall movement by catheter conventionally placed the apex. For reliable evaluation mouse lower urinary tract function, we established novel which was anterior wall, combination ultrasonography. This...
Abstract When bacteria enter the bladder lumen, a first-stage active defensive mechanism flushes them out. Although urinary frequency induced by bacterial cystitis is well-known response against bacteria, underlying remains unclear. In this study, using mouse model of acute cystitis, we demonstrate that urothelium senses luminal extracellular lipopolysaccharide (LPS) through Toll-like receptor 4 and releases transmitter ATP. Moreover, analysis purinergic P2X 2 3 receptor-deficient mice...
Nocturnal polyuria is the most frequent cause of nocturia, a common disease associated with compromised quality life and increased mortality. Its pathogenesis complex, detailed underlying mechanism remains unknown. Herein, we report that concomitant intake high-salt diet reduced nitric oxide (NO) production achieved through Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) administration in mice resulted nocturnal recapitulating clinical features humans. High salt under NO...
Objectives To investigate details of sexual function erectile dysfunction in J apanese patients taking phosphodiesterase type 5 inhibitors. Methods A version the P sychological and I nterpersonal R elationship S cales‐ hort F orm was used to carry out a nationwide survey using nternet. total 556 (age 30–70 years) who had been prescribed inhibitor attempted intercourse within past 6 months were included this survey. Scores compared relation inhibitors most frequently taken months. Results In...
Testosterone production is important in males, and various physical psychological abnormalities occur individuals with low testosterone levels. In the present study, we aimed to examine effects of longitudinal changes total levels same cohort. We included 178 male subjects who visited our hospital multiple times between 2018 2023 for medical checkups at least 3 years. The median baseline age level (TT) cohort were 61 years 4.74 ng/mL, respectively. patients divided into four groups based on...
To report the long-term outcome of surveillance for stage I seminoma at a single institution in Japan.A retrospective review medical records 64 patients who underwent orchiectomy between January 1982 and December 2005 was carried out. All them were managed by seminoma.Median follow-up time 123.8 months. Of patients, seven developed relapse. Four relapses occurred within first year after orchiectomy, but three over 4 years orchiectomy. The actuarial relapse-free rates 5, 10, 15 92.1%, 90.0%,...
This study aimed to investigate the ability of creatine-chemical exchange saturation transfer (Cr-CEST) technique assessed through 7-T MRI evaluate cisplatin-induced testicular damage.We used 8-10 weeks C57BL/6 mice (n = 10) that were divided into a control group 5) and cisplatin-treated 5). The cisplatin received at dose 15 mg/kg, via intraperitoneal injection, while saline. MR images mouse testes acquired under anesthesia 18 days after injection using horizontal scanner. pulse sequence...
Introduction We aimed to clarify the presence and localization of prostate microbiota examine its association with benign enlargement (BPE). Methods The tissues catheterized urine from 15 patients were analyzed by 16S metagenomic analysis compared show that was not a contaminant urinary microbiota. Fluorescence in situ hybridization (FISH) (ISH) using specific probe for eubacteria performed on tissue bacteria prostate. BPE group defined as volume ≥30 mL, non-BPE <30 mL. two groups...
Varicocoele-induced male infertility potentially involves oxidative stress. Although varicocoelectomy is recommended for varicocoele patients presenting abnormal semen findings, no pharmacotherapeutic methods currently exist. We have recently developed a silicon-based agent that produces hydrogen by the reaction with water.
Is actin capping protein (CP) β3 involved in human spermatogenesis and male infertility?Human CPβ3 (hCPβ3) is expressed testis, changes its localization dynamically during spermatogenesis, has some association with infertility.The testis-specific α subunit of CP (CPα3) was previously identified human, mutations the cpα3 gene mouse were shown to induce malformation sperm head infertility. However, CPβ3, which considered be a heterodimeric counterpart CPα3, been neither characterized nor...