A5101419597- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Silicon Nanostructures and Photoluminescence
- Acute Myeloid Leukemia Research
- Viral-associated cancers and disorders
- Hydrogen's biological and therapeutic effects
- Semiconductor materials and devices
- Nanowire Synthesis and Applications
- Polyomavirus and related diseases
- Chronic Myeloid Leukemia Treatments
- Anesthesia and Neurotoxicity Research
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Thin-Film Transistor Technologies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Advancements in Battery Materials
- Eosinophilic Disorders and Syndromes
- CNS Lymphoma Diagnosis and Treatment
- Fungal Infections and Studies
- Silicon and Solar Cell Technologies
- Cytomegalovirus and herpesvirus research
- Transplantation: Methods and Outcomes
- Platelet Disorders and Treatments
- Semiconductor materials and interfaces
Osaka University
2016-2025
Osaka City General Hospital
2025
Osaka Prefectural Medical Center
2025
Yamaguchi University
2019-2025
Nagano Red Cross Hospital
2015-2024
Osaka Research Institute of Industrial Science and Technology
2002-2024
Nagoya University
2012-2023
Departamento de Salud
2023
Universidad Alfonso X el Sabio
2023
Universidad Complutense de Madrid
2019-2022
Extranodal NK/T-cell lymphoma, nasal type (ENKL) is an Epstein-Barr virus (EBV)-associated lymphoma for which a new chemotherapeutic regimen called SMILE (steroid, methotrexate, ifosfamide, L-asparaginase, and etoposide) recently showed promising results.The amount of EBV-DNA was prospectively measured in whole-blood plasma samples by real-time quantitative PCR from 26 patients registered the phase II study.Before treatment, detected 22 whole blood with median number 3,691 copies/mL (range:...
Neural crest cells generate numerous derivatives, including pigment cells, and are a model for studying how fate specification from multipotent progenitors is controlled. In mammals, the core gene regulatory network melanocytes (their only cell type) contains three transcription factors, Sox10, Pax3 Mitf, with latter considered master regulator of melanocyte development. teleosts, which have to four types (melanophores, iridophores xanthophores, plus leucophores e.g. in medaka), networks...
Si and its oxide are nonpoisonous materials, thus, it can be taken for medical effects. We have developed a method of generation hydrogen by use reactions nanopowder with water in the neutral pH region. is fabricated simple bead milling method. reacts to generate even cases where set at region between 7.0 8.6. The rate strongly depends on case 8.0, ∼55 ml/g which corresponds that contained approximately 3 L saturated hydrogen-rich generated 1 h. reaction greatly increases pH, indicating...
Abstract The major limitation of cord blood transplantation (CBT) for adults remains the delayed hematopoietic recovery and higher incidence graft failure, which result in a risk early mortality CBT. We evaluated overall survival (OS), non‐relapse (NRM), neutrophil engraftment, acute graft‐vs‐host disease, cause death among 9678 adult patients who received single‐unit CBT Japan between 1998 2017. probability OS at 100 days was 64.4%, 71.7%, 78.9% periods to 2007, 2008 2012, 2013 2017,...
Nowadays, ca. 176,640 tons/year of silicon (Si) (>4N) is manufactured for Si wafers used semiconductor industry. The production the highly pure inevitably includes very high-temperature steps at 1400-2000 °C, which energy-consuming and environmentally unfriendly. Inefficiently, 45-55% such costly lost simply as sawdust in cutting process. In this work, we develop a cost-effective way to recycle high-performance anode material lithium-ion batteries. By beads-milling process, nanoflakes with...
Abstract Unrelated cord blood transplantation (CBT) is an alternative curative option for adult patients with acute myeloid leukemia (AML) who need allogeneic hematopoietic cell (HCT) but lack HLA-matched related or unrelated donor. However, large-scale data are lacking on CBT outcomes unselected AML. To investigate the trends of survival and engraftment after over past 22 years, we retrospectively evaluated AML in Japan according to time period (1998–2007 vs 2008–2013 2014–2019). A total...
We describe a case of Cronkhite-Canada syndrome associated with sigmoid colon cancer, and provide literature review. A 77-year-old man was diagnosed cancer after presenting hypoproteinemia, nail atrophy, loss scalp hair, hyperpigmentation, gastrointestinal polyposis. The findings were consistent syndrome. polyps histologically serrated adenomas, whose crypts showed saw-toothed growth pattern dysplasia, or tubular adenoma. has been reported in 31 cases. availability histologic material...
We have developed Si-based agent which can generate a large amount of hydrogen. continues generating hydrogen for more than 24 h by the reaction with water under conditions similar to those in bowels, i.e., pH8.3 and 36 °C, generates ~400 mL To investigate beneficial effects diseases associated oxidative stress, is administered remnant kidney rats Parkinson's disease mice. Rats are fed control or agent-containing diet 8 weeks. found greatly suppress development renal failure parameters...
The pharmacokinetics of arsenic species in a Japanese patient with relapsed acute promyelocytic leukemia (APL) treated trioxide at daily dose 0.08 mg/kg was investigated. After achieving complete remission on Day 35 during the induction therapy trioxide, we collected serum and urine samples Days 4 5 consolidation trioxide. concentrations inorganic methylated metabolites were measured by HPLC/ICP-MS. restricted taking seafood for 3 d before start administration sampling period order to avoid...
In Parkinson's Disease (PD), the peripheral changes in functional capacity and redox state of immune cells has been scarcely investigated, especially early PD stages. Aging is a risk factor for PD, age-related impairment system, based on chronic-oxidative stress situation, involved rate aging. We analyzed several functions isolated blood neutrophils mononuclear from stage 2 patients, compared results to those healthy elderly adult controls. Several oxidative damage parameters were studied...
To determine whether a difference in donor source affects the outcome of transplantation for patients with primary myelofibrosis (PMF), retrospective study was conducted using national registry data on who received first allogeneic hematopoietic cell (HCT) related BM (n=19), PBSCs (n=25), unrelated (n=28) or umbilical cord blood (UCB; n=11). The 5-year OS rates after BM, PBSC and were 63%, 43% 41%, respectively, 2-year rate UCB 36%. On multivariate analysis, not significant factor predicting...
Maternal immune activation (MIA) is triggered by infection or autoimmune predisposition during pregnancy, and cytokines produced MIA are transmitted through the placenta to fetal brain, implicating at onset risks vulnerability for developmental psychiatric disorders, such as autism spectrum disorder (ASD) schizophrenia. To address these kinds of problem in child health, we have developed a silicon (Si)-based hydrogen-producing antioxidant (Si-based agent) that continuously effectively...
Bacterial meningitis (BM) is a life-threatening central nervous system infection with potential for severe neurological sequelae. High mobility group box 1 (HMGB1) known as late inflammatory mediator associated lethal pathology. This study aims to investigate the serial cerebrospinal fluid (CSF) concentrations of HMGB1 in children BM and its relationship prognosis. retrospective cohort included BM, aseptic (AM), controls. CSF samples were collected serially from patients once those AM...
Earlier reports suggested that umbilical cord blood transplantation (UCBT) for aplastic anemia (AA) was feasible in alternative transplantation. To identify differences outcomes of UCBT and HLA-matched or mismatched unrelated bone marrow (UBMT) adults with AA, we analyzed registry data the Japan Society Hematopoietic Cell Transplantation compared results (n = 69) to 8/8-matched 101), 7/8-matched 65), 6/8-matched 37) UBMT. The period from 2002 2012, patients 16 years older AA were eligible....
The activated partial thromboplastin time (APTT) assay is a basic hemostatic based on the it takes for clots to form in plasma samples after addition of calcium chloride. It used screen various coagulation disorders. Several previous reports have suggested that magnesium (Mg) might contribute reactions by binding specific proteins. We investigated effects Mg APTT. In healthy controls, APTT was significantly prolonged proportion increase concentration chloride range from 2.1 16.7 mmol/L....
Organ ischemia-reperfusion injury (IRI), which is unavoidable in kidney transplantation, induces the formation of reactive oxygen species and causes organ damage. Although efficacy molecular hydrogen (H2) IRI has been reported, oral intake H2-rich water inhalation H2 gas are still not widely used clinical settings because lack efficiency difficulty handling. We successfully generated large quantities molecules by crushing silicon (Si) to nano-sized Si particles (nano-Si) were allowed react...
Abstract Ulcerative colitis (UC) is a non-specific inflammatory bowel disease that causes ulcers and erosions in the colonic mucosa becomes chronic with cycles of amelioration exacerbation. Because its exact etiology remains largely unclear, primary therapy limited to symptomatic treatment, development new therapeutic agent for UC highly desired. one pathogenesis involvement oxidative stress, it likely an appropriate antioxidant will be effective UC. Our silicon (Si)-based agent, when...