A5058803209- Neonatal Health and Biochemistry
- Cytomegalovirus and herpesvirus research
- Neonatal Respiratory Health Research
- Heme Oxygenase-1 and Carbon Monoxide
- Herpesvirus Infections and Treatments
- Parvovirus B19 Infection Studies
- Metabolism and Genetic Disorders
- Birth, Development, and Health
- Methemoglobinemia and Tumor Lysis Syndrome
- Infectious Encephalopathies and Encephalitis
- Neonatal and fetal brain pathology
- Neonatal and Maternal Infections
- Diabetes and associated disorders
- Neurogenetic and Muscular Disorders Research
- Respiratory viral infections research
- Diet and metabolism studies
- Congenital Diaphragmatic Hernia Studies
- Craniofacial Disorders and Treatments
- Toxoplasma gondii Research Studies
- Streptococcal Infections and Treatments
- Cleft Lip and Palate Research
- Pancreatic function and diabetes
- RNA modifications and cancer
- Diabetes Management and Research
- Viral gastroenteritis research and epidemiology
Nihon University
2018-2025
Nihon University Itabashi Hospital
2019-2025
Osaka University
2025
Mie Chuo Medical Center
2024
Japan Pediatric Society
2020-2023
Fujieda Municipal General Hospital
2023
Osaka Hospital
2020
Kobe University
2010-2019
Kobe University Hospital
2010-2018
Gifu Pharmaceutical University
2017
Background and objectives Alport syndrome comprises a group of inherited heterogeneous disorders involving CKD, hearing loss, ocular abnormalities. Autosomal dominant caused by heterozygous mutations in collagen 4A3 and/or 4A4 accounts for <5% patients. However, the clinical, genetic, pathologic backgrounds patients with autosomal remain unclear. Design, setting, participants, & measurements We conducted retrospective analysis 25 genetically proven their family members (a total 72...
IntroductionX-linked Alport syndrome (XLAS) is a hereditary disease characterized by progressive nephritis, hearing loss, and ocular abnormalities. Affected male patients usually progress to end-stage renal in early or middle adulthood, severity strongly correlated with genotype. However, the clinical course female has rarely been reported.MethodsWe conducted retrospective analysis of females genetically proven XLAS (n = 275) their affected family members 61) from 179 Japanese families....
Abstract Kawasaki disease (KD) is a systemic vasculitis and childhood febrile that can lead to cardiovascular complications. The diagnosis of KD depends on its clinical features, thus it sometimes difficult make definitive diagnosis. In order identify diagnostic serum biomarkers for KD, we explored KD-related proteins, which differentially expressed during the acute recovery phases two patients by mass spectrometry (MS). We identified total 1,879 proteins MS-based proteomic analysis. levels...
The aim of this prospective cohort study was to evaluate the efficacy maternal screening for congenital cytomegalovirus infection (CCI) using (CMV) immunoglobulin G (IgG) and IgG avidity index (AI).Pregnant women underwent CMV AI measurements. IgG-negative remeasurement after educational intervention. Women with an ≤45% received further examinations, including measurement IgM. All newborns polymerase chain reaction analyses urine, CCI diagnosed by detection CMV-DNA in urine. Primary defined...
Abstract Leigh syndrome is a major phenotype of mitochondrial diseases in children. With new therapeutic options being proposed, assessing the mortality and clinical condition patients crucial for evaluating therapeutics. As data are scarce Japan, we analysed rate Japanese that diagnosed since 2007. Data from 166 with 2007 to 2017 were reviewed. Patients' present status, method ventilation feeding, degree disability as April 2018 was analysed. Overall, 124 (74.7%) living, 40 (24.1%)...
Abstract Abnormal gut motility is a feature of several mitochondrial encephalomyopathies, and mutations in genes such as TYMP POLG, have been linked to these rare diseases. The human genome encodes three DNA ligases, which only one, ligase III (LIG3), has splice variant crucial for health. We investigated the effect reduced LIG3 activity resulting dysfunction seven patients from independent families, who showed common occurrence dysmotility neurological manifestations reminiscent...
Our aims were to determine the clinical impact of oral valganciclovir (VGCV) in infants aged ≤2 months with congenital cytomegalovirus (CMV) disease and evaluate efficacy VGCV when initiated beyond neonatal period. The multicenter, single-arm, open-label trial was conducted Japan. Twenty-five CMV involving central nervous system enrolled treated for 6 months. primary endpoint change whole blood load before after treatment. secondary auditory brainstem response (ABR) Changes ABR assessed...
In Japan, the mortality rate of extremely low birth weight (ELBW) infants is notably in comparison with other developed countries, but prevalence chronic lung disease (CLD) and retinopathy prematurity (ROP) relatively high. This study aimed to estimate morbidity ELBW born 2015 who were admitted neonatal intensive care units (NICUs) Japan examine factors that affected short-term outcomes these infants. We also compared 2005, 2010, 2015.We analyzed mortality, morbidity, related infants, using...
Objectives: This study aimed to examine the natural progression of cranial shape from end helmet therapy for deformational plagiocephaly 1 year age. Methods: included infants with moderate severe who began treatment at our department between December 2022 and July 2023. The was assessed using a 3D scanner (VECTRA®H2) start treatment, 12 months Changes in Cranial Vault Asymmetry Index (ΔCVAI), an indicator deformity, severity deformity (normal, mild, moderate, severe, very severe) were...
<title>Abstract</title> Background Low birthweight infants have high risk of developing chronic kidney disease (CKD) in later life, however, the pathogenesis this remains unclear. This study aimed to investigate underlying mechanism using a low birthweight-non-obese hyperglycemic adulthood mouse model. Methods Pregnant ICR-strain mice underwent uterine artery ligation at day 16.5 gestation induce fetal hypoxia (ischemic group, I). Female newborns were weaned 4 weeks age and fed normal diet...
Abstract Background Clesrovimab is an investigational, long-acting monoclonal antibody for the prevention of RSV lower respiratory tract infection (LRI) in infants, including those at high risk severe disease due to serious comorbidity or premature birth. Methods This a planned interim analysis (IA) randomized, controlled, phase 3 trial infants entering their first season recommended receive palivizumab prematurity (≤35 weeks gestational age), chronic lung (CLD) prematurity, hemodynamically...
We performed a search for the <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline"><a:msub><a:mi>K</a:mi><a:mi>L</a:mi></a:msub><a:mo stretchy="false">→</a:mo><a:msup><a:mi>π</a:mi><a:mn>0</a:mn></a:msup><a:mi>ν</a:mi><a:mover accent="true"><a:mi>ν</a:mi><a:mo stretchy="false">¯</a:mo></a:mover></a:math> decay using data taken in 2021 at J-PARC KOTO experiment. With newly installed counters and new analysis method, expected background was suppressed to <f:math...
Abstract Background We aimed to reveal the transmission rate of coronavirus disease 2019 (COVID‐19) and clinical features congenital neonatal COVID‐19 disclose efficacy maternally transferred antibodies by maternal vaccination against severe acute respiratory syndrome 2 (SARS‐CoV‐2). Methods This multicenter, prospective observational study included a comprehensive testing protocol with appropriate precautions. Mothers infants were enrolled classified into an active infection group (mothers...
Congenital Toxoplasma gondii (T. gondii) infection, which can be caused by a primary T. infection during pregnancy, results in severe neurological sequelae affected children. We have been conducting prospective cohort study since January 2019 on pregnant women who were suspected of having based serological tests. In this study, congenital was diagnosed using semi-nested polymerase chain reaction (PCR) to detect the B1 gene body fluids newborns. Up until December 2023, forty-one newborns born...