A5033413455- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Infant Development and Preterm Care
- Neuroscience of respiration and sleep
- Neonatal Health and Biochemistry
- Retinopathy of Prematurity Studies
- Respiratory Support and Mechanisms
- Preterm Birth and Chorioamnionitis
- Birth, Development, and Health
- Congenital Anomalies and Fetal Surgery
- Infant Nutrition and Health
- Assisted Reproductive Technology and Twin Pregnancy
- Injury Epidemiology and Prevention
- Esophageal and GI Pathology
- Intestinal Malrotation and Obstruction Disorders
- Neonatal and fetal brain pathology
- Genomic variations and chromosomal abnormalities
- Prenatal Screening and Diagnostics
- Immunodeficiency and Autoimmune Disorders
- Face Recognition and Perception
- Spinal Dysraphism and Malformations
- Urological Disorders and Treatments
- Disaster Response and Management
- Down syndrome and intellectual disability research
- Retinal Diseases and Treatments
Osaka Women's and Children's Hospital
2018-2024
University of Fukui
2024
Japan Pediatric Society
2023
Osaka University
2006-2020
Osaka Medical Center for Cancer and Cardiovascular Diseases
1998-2017
Osaka University Hospital
2011-2017
Showa University
2005
Memorial Hospital
2005
UCLA Medical Center
1997-1998
Harbor–UCLA Medical Center
1997-1998
We hypothesized that initiation of ventilation in preterm lambs with high volumes would cause lung injury and decrease the subsequent response to surfactant treatment. Preterm were randomized for 30 min after birth 5 ml/kg (VT5), 10 (VT10), or 20 (VT20) tidal then ventilated approximately achieve arterial PCO2 values 50 Torr 6 h age. VT20 had lower compliances, ventilatory efficiencies, higher recoveries protein, alveolar lavages decreased compliances when tested rabbits than VT5 VT10 lambs....
<h3>Aim:</h3> The aim of the study was to evaluate short-term efficacy intravitreal injections bevacizumab for severe retinopathy prematurity (ROP). <h3>Methods:</h3> A retrospective chart review conducted 23 consecutive eyes (stage 3, three eyes; 4A, 18 4B, two eyes) 14 patients with vascularly active ROP considered at high risk progression or development tractional retinal detachment despite conventional laser ablation therapy. Patients received an injection (0.5 mg), either as initial...
Chromosomal aneuploidy and specific gene mutations are recognized early hallmarks of many oncogenic processes. However, the net effect these abnormalities has generally not been explored. We focused on transient myeloproliferative disorder (TMD) in Down syndrome, which is characteristically associated with somatic GATA1. To better understand functional interplay between trisomy 21 GATA1 hematopoiesis, we constructed cellular disease models using human induced pluripotent stem cells (iPSCs)...
In newborn screening (NBS), it is important to consider the availability of multiplex assays or other tests that can be integrated into existing systems when attempting implement NBS for new target diseases. Recent developments in innovative testing technology have made possible simultaneously screen severe primary immunodeficiency (PID) and spinal muscular atrophy (SMA) using quantitative real-time polymerase chain reaction (qPCR) assays. We describe our experience optional PID SMA Osaka,...
Mice that are surfactant protein (SP) A deficient [SP-A(-/-)] have no apparent abnormalities in lung function. To understand the contributions of SP-A to surfactant, biophysical properties and functional characteristics from normal [SP-A(+/+)] SP-A(-/-) mice were evaluated. SP-A-deficient had a lower buoyant density, percentage large-aggregate forms, an increased rate conversion small-aggregate forms with surface area cycling, sensitivity inhibition minimum tension by plasma protein, tubular...
Prostaglandin D 2 (PGD) is synthesized by hematopoietic PGD synthase (HPGDS) or lipocalin-type PGDS (L-PGDS), depending on the organ in which it produced, and binds specifically to either DP 1 receptors. We investigated role of pathogenesis hypoxic-ischemic encephalopathy (HIE) neonatal mice at postnatal day 7. In wild-type mice, hypoxia-ischemia increased production brain up 90-fold compared with level sham-operated brains 10 min after cessation hypoxia. Whereas size infarct was not changed...
Fetal serum levels of calcium and phosphate are higher than those in the maternal levels. Although α-Klotho is known to participate metabolism adults, its role perinatal period remains unknown.This study aimed determine baseline soluble fetuses compare them with neonates, mothers, adults clarify whether involved fetal-specific regulation metabolism.We conducted a cross-sectional evaluation healthy babies (at birth and/or at 4 d after birth), their adult volunteers one hospital.Twenty-one (23...
In Japan, the mortality rate of extremely low birth weight (ELBW) infants is notably in comparison with other developed countries, but prevalence chronic lung disease (CLD) and retinopathy prematurity (ROP) relatively high. This study aimed to estimate morbidity ELBW born 2015 who were admitted neonatal intensive care units (NICUs) Japan examine factors that affected short-term outcomes these infants. We also compared 2005, 2010, 2015.We analyzed mortality, morbidity, related infants, using...
Background Outcomes of prenatal covariate-adjusted outborn very-low-birth-weight infants (VLBWIs) (≤1500 g) remain uncertain. Objective To compare morbidity and mortality between inborn VLBWIs. Design Observational cohort study using inverse-probability-of-treatment weighting. Setting Neonatal Research Network Japan. Patients Singleton VLBWIs with no major anomalies admitted to a neonatal intensive care unit from 2012 2016. Methods Inverse-probability-of-treatment weighting propensity scores...
We investigated whether the style of ventilation would influence respiratory physiology or surfactant metabolism in surfactant-treated preterm lambs. Preterm lambs were delivered at 131 ± 1 d gestation and treated with an organic solvent extract sheep (100 mg/kg). The randomized to peiods 2 h, 5 10 24 a low rate (15 breaths/min) high Vt ml/kg), (50 (8 high-frequency oscillatory (HFOV). Gas exchange lung volumes similar across time for different styles. Saturated phosphatidylcholine (SatPC)...
Chromosome abnormalities induces profound alterations in gene expression, leading to various disease phenotypes. Recent studies on yeast and mammalian cells have demonstrated that aneuploidy exerts detrimental effects organismal growth development, regardless of the karyotype, suggesting aneuploidy-associated stress plays an important role pathogenesis. However, whether how this effect alters cellular homeostasis long-term features human are not fully understood. Here, we aimed investigate...
Objective To assess the association between gestational age classification at birth and risk of neurodevelopmental impairments 3 years. Design Cohort study using Japan Environment Children’s Study database. Patients A total 86 138 singleton children born without physical abnormalities 32–41 weeks gestation enrolled January 2011 March 2014. Main outcome measures Neurodevelopmental impairment, evaluated Ages Stages Questionnaire (third edition). Methods Logistic regression analysis was used to...
Human cytomegalovirus (CMV) is a leading congenital infectious agent in developed countries. In the past, incidence of infection has been rather low Japan because high seroprevalence CMV present young women. However, this decreasing recent years, so that Japanese neonates may increase and approach level seen other The method was used for detecting DNA reported by Barbi et al. [Barbi (1996): Clin Diagn Virol 6:27–32] using dried blood spot on filter paper, to diagnose neonates. This effective...
Previous studies have proposed that humans may be born with mechanisms attend to conspecifics. However, as previous relied on stimuli featuring human adults, it remains unclear whether infants only adult or the entire species. We found 1-month-old (n = 23) were able differentiate between and monkey infants' faces; however, they exhibited no preference for faces over 24) discriminated individual differences within category of 30). successfully replicated findings 42) preferred humans, even...
Abstract Eukaryotic genomes are organised into complex higher-order structures within the nucleus, and three-dimensional arrangement of chromosomes is functionally important for global gene regulation. The existence supernumerary chromosome 21 in Down syndrome may perturb nuclear architecture at different levels, which normally optimised to maintain physiological balance expression. However, it has not been clearly elucidated whether how aberrant configuration affects activities. To...
Abstract Individuals with Down syndrome (DS) commonly show unique pathological phenotypes throughout their life span. Besides the specific effects of dosage-sensitive genes on chromosome 21, recent studies have demonstrated that gain a exerts an adverse impact cell physiology, regardless karyotype. Although dysregulated transcription and perturbed protein homeostasis are observed in common human fibroblasts trisomy 18, 13, whether how this aneuploidy-associated stress acts other lineages...
Acute myeloblastic leukemia, subtype M1, was diagnosed in a 39-year-old G2P1 Japanese woman at 21 weeks’ gestation. Remission-induction polychemotherapy, including daunorubicin, performed for one cycle, did not lead to remission. Second-line chemotherapy, idarubicin, administrated during the early third trimester of pregnancy. Septic shock occurred due severe myelosuppression. An emergent cesarean section response nonreassuring pattern fetal heart rate and rapid decrease amniotic fluid. The...
<b><i>Background:</i></b> Newborn infants hospitalised in the neonatal intensive care unit (NICU) are vulnerable to natural disasters. However, publications on evacuation from NICUs sparse. The 2016 Kumamoto Earthquakes caused serious damage City Hospital and its level III regional core NICU. Local/neighbour NICU teams disaster-communication team of a academic society cooperated evacuate 38 newborn ward. <b><i>Objective:</i></b> aim this paper...