A5069506366- Autism Spectrum Disorder Research
- Child Nutrition and Feeding Issues
- Sleep and related disorders
- Sleep and Wakefulness Research
- Family and Disability Support Research
- Attention Deficit Hyperactivity Disorder
- Genetics and Neurodevelopmental Disorders
- Lysosomal Storage Disorders Research
- Child Development and Digital Technology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Neurogenesis and neuroplasticity mechanisms
- Children's Physical and Motor Development
- Advanced Neuroimaging Techniques and Applications
- Infant Development and Preterm Care
- Behavioral and Psychological Studies
- Restless Legs Syndrome Research
- Child and Animal Learning Development
- Infant Health and Development
- Virology and Viral Diseases
- Muscle Physiology and Disorders
- RNA regulation and disease
- Fetal and Pediatric Neurological Disorders
- Early Childhood Education and Development
Osaka University
2015-2024
University of Fukui
2014-2023
Kanazawa University
2011-2023
Chiba University
2014-2023
Hamamatsu University School of Medicine
2011-2023
Osaka University Hospital
2016-2021
Kansai University
2021
National Center For Child Health and Development
2021
Center for Children
2008-2017
Kurume University
2017
Prostaglandin (PG) D 2 is well known as a mediator of inflammation. Hematopoietic PGD synthase (HPGDS) responsible for the production involved in inflammatory responses. Microglial activation and astrogliosis are commonly observed during neuroinflammation, including that which occurs demyelination. Using genetic demyelination mouse twitcher , model human Krabbe’s disease, we discovered activated microglia expressed HPGDS astrocytes DP 1 receptor brain these mice. Cultured actively produced...
Niemann-Pick type C1 (NPC1) disease is a fatal neurodegenerative characterized by neuronal lipid storage and progressive Purkinje cell loss in the cerebellum. We investigated whether therapeutic approaches to bypass cholesterol trafficking defect NPC1 might delay progression npc1(-/-) mouse model. show that neurosteroid allopregnanolone (ALLO) T0901317, synthetic oxysterol ligand, act concert onset of neurological symptoms prolong lifespan mice. ALLO T0901317 therapy preserved cells,...
Objective: Oxytocin (OT) has been a candidate for the treatment of autism spectrum disorders (ASD), and impact intranasally delivered OT on ASD investigated. However, most previous studies were conducted by single-dose administration to adults; and, therefore, long-term effect nasal patients its children remain be clarified. Methods: We singled-armed, open-label study in which was administered over long term eight male youth with (10–14 years age; intelligence quotient [IQ] 20–101). The...
The conformational change in amyloid beta (Abeta) peptide from its monomeric form to aggregates is crucial the pathogenesis of Alzheimer's disease (AD). In healthy brain, some unidentified chaperones appear prevent aggregation Abeta. Here we reported that lipocalin-type prostaglandin D synthase (L-PGDS)/beta-trace, most abundant cerebrospinal fluid (CSF) protein produced was localized plaques both AD patients and AD-model Tg2576 mice. Surface plasmon resonance analysis revealed...
We applied high-resolution laser-scanning microscopy, electron and non-radioactive in situ hybridization histochemistry to determine the cellular intracellular localization of lipocalin-type prostaglandin D synthase, major brain-derived protein component cerebrospinal fluid, its mRNA leptomeninges, choroid plexus, parenchyma adult rat brain. Both immunoreactivity for synthase were located arachnoid barrier cells, trabecular pia mater cells. Furthermore, meningeal macrophages perivascular...
Abstract Autism spectrum disorder (ASD) and attention-deficit/hyperactivity (ADHD) share high rates of comorbidity, with the Diagnostic Statistical Manual Mental Disorders-Fifth Edition now acknowledging comorbid diagnosis ASD ADHD. Although structural abnormalities in prefrontal cortex, cerebellum, basal ganglia occur both ADHD, no studies have focused exclusively on patients We thus aimed to clarify features developmental changes ADHD a relatively large sample from two sites. Ninety-two...
Morphological alterations of oligodendrocytes (OLs) leading to their depletion were studied in the genetic demyelinating mutant, twitcher, a murine model globoid cell leukodystrophy (GLD). With pi-glutathione-S-transferase immunostaining, OLs with multiple varicose processes recognized early stages and adjacent areas demyelination then cytoplasm as well became shrunken progression disease. These labeled by TUNEL method, indicative apoptotic death. The ultrastructural features cells noted...
The genetic demyelinating mouse "twitcher" is a model of the human globoid cell leukodystrophy, caused by galactosylceramidase (GALC) deficiency. Demyelination in twitcher brain secondary to apoptotic death oligodendrocytes (OLs). Lipocalin-type prostaglandin (PG) D synthase (L-PGDS), protein expressed mature OLs, was progressively upregulated OLs; whereas expression OL-associated proteins such as carbonic anhydrase II, myelin basic protein, and myelin-associated glycoprotein downregulated...
Prostaglandin D 2 (PGD) is synthesized by hematopoietic PGD synthase (HPGDS) or lipocalin-type PGDS (L-PGDS), depending on the organ in which it produced, and binds specifically to either DP 1 receptors. We investigated role of pathogenesis hypoxic-ischemic encephalopathy (HIE) neonatal mice at postnatal day 7. In wild-type mice, hypoxia-ischemia increased production brain up 90-fold compared with level sham-operated brains 10 min after cessation hypoxia. Whereas size infarct was not changed...
Prostaglandin (PG) D2 is produced in activated microglia by the action of hematopoietic PGD synthase (HPGDS) and plays important roles neuroinflammation. Because fact that neuroinflammation accelerates progression Alzheimer disease (AD) has been documented, we investigated whether PGD2 also involved pathology AD. Here, report level mRNA receptor for (DP1) was increased AD brains compared with non-AD brains. Immunocytochemical analysis showed HPGDS expression to be localized surrounding...
Objectives The aims of this study were to investigate the prevalence sleep bruxism in children Japan, and its relationships with sleep‐related factors daytime problematic behavior. Subjects Methods Guardians 6023 aged 2–12 years completed Japanese Sleep Questionnaire. Multiple regression analysis structural equation modeling performed. Results was reported 21.0% ( n = 1263): highest age group 5–7 (27.4%). showed that had significant correlations OR : 1.72; P < 0.0001), ‘Moves a lot during...
Abstract This study examines the efficacy of Japanese version Program for Education and Enrichment Relational Skills (PEERS), which focuses on improving social functioning through making friends maintaining good relationships adolescents with autism spectrum disorder (ASD) without intellectual disabilities. Originally developed in United States, PEERS is one few evidence-based skills training programs youth ASD. The present shows that linguistic cultural modifications, effective ASD Japan....
Niemann-Pick disease type C (NPC) is an autosomal recessive neurovisceral lipid storage caused by a loss of NPC1 function, which results in perturbation intracellular cholesterol transport.In BALB/c npc nih mice, the murine ortholog gene mutated.In NPC mouse, hypomyelination conspicuous cerebral white matter and corpus callosum addition to neuronal storage.However, pathogenesis on not well elucidated.We hypothesized that mice resulted from either defective differentiation oligodendrocyte...
The aim of this study was to investigate the differential responses primary auditory cortex stimuli in autistic spectrum disorder with or without hypersensitivity. Auditory-evoked field values were obtained from 18 boys (nine and nine hypersensitivity) 12 age-matched controls. Autistic hypersensitivity showed significantly more delayed M50/M100 peak latencies than control. M50 dipole moments group larger those other two groups [corrected]. correlated severity hypersensitivity; furthermore,...
The aim of this study was to investigate the differential time-course responses auditory cortex repeated stimuli in children with autism spectrum disorder (ASD) showing hypersensitivity. Auditory-evoked field values were obtained from 21 boys ASD (12 and 9 without hypersensitivity) 15 age-matched typically developing controls. M50 dipole moments significantly increased during only hypersensitivity compared those for other two groups. having also showed more prolonged response duration than...
This study compared cross-sectional data from online surveys describing the sleep behavior of infants and caregivers in March 2020 (the school closure period during early stages COVID-19 pandemic; n = 295, 23.8 ± 3.8 months old) 2019 (before 2017, 24.2 old). In comparing those two points time, no significant differences were found wake-up times (2019: 7:19 0:46 am vs. 2020: 7:18 0:47 am, p 0.289), bedtimes (21:01 0:48 pm 21:04 0:53 pm, 0.144), or nocturnal (593.7 43.9 min 588.1 50.3 min,...
Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) is a dually functional protein, acting both as PGD2-synthesizing enzyme and an extracellular transporter of various lipophilic small molecules. L-PGDS expressed in oligodendrocytes (OLs) the central nervous system up-regulated OLs twitcher mouse, model globoid cell leukodystrophy (Krabbe's disease). We investigated whether up-regulation either unique to Krabbe's disease or more generalized phenomenon lysosomal storage disorders (LSDs),...
Many studies have reported poor motor performance in autism spectrum disorder (ASD); however, the underlying brain mechanisms remain unclear. Recent neuroimaging suggested that abnormalities of white matter (WM) are related to features ASD. In this study, we used voxel‐based morphometry (VBM) investigate which WM regions correlate with children ASD, and whether volume those differed between ASD typically developing (TD) children. The subjects included 19 20 TD controls. Motor was assessed...