A5079720174- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Infant Development and Preterm Care
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Intestinal Malrotation and Obstruction Disorders
- Down syndrome and intellectual disability research
- Preterm Birth and Chorioamnionitis
- Retinopathy of Prematurity Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Genomic variations and chromosomal abnormalities
- Congenital gastrointestinal and neural anomalies
- Neonatal Health and Biochemistry
- Infant Nutrition and Health
- Child and Adolescent Health
- Prenatal Screening and Diagnostics
- Single-cell and spatial transcriptomics
- Chromatin Remodeling and Cancer
- PI3K/AKT/mTOR signaling in cancer
- Birth, Development, and Health
- Signaling Pathways in Disease
- Pregnancy-related medical research
- Zebrafish Biomedical Research Applications
- Neonatal and Maternal Infections
- Hematological disorders and diagnostics
Saga University
2025
Osaka Women's and Children's Hospital
2018-2024
Murata (Japan)
2024
Osaka University
2016-2021
Osaka Medical Center for Cancer and Cardiovascular Diseases
2013-2017
Doshisha University
2003-2013
Chromosomal aneuploidy and specific gene mutations are recognized early hallmarks of many oncogenic processes. However, the net effect these abnormalities has generally not been explored. We focused on transient myeloproliferative disorder (TMD) in Down syndrome, which is characteristically associated with somatic GATA1. To better understand functional interplay between trisomy 21 GATA1 hematopoiesis, we constructed cellular disease models using human induced pluripotent stem cells (iPSCs)...
To assess lung function and long-term respiratory outcomes in extremely low birth weight (ELBW) survivors.ELBW, especially with complications the neonatal period, affects at a later age.Longitudinal retrospective study.Lung was evaluated 89 ELBW survivors (at ages 8 12) or without history of bronchopulmonary dysplasia (BPD) bubbly/cystic appearance period.FVC, FEV1 , FEF50 FEF75 were measured using spirometry. Two-way repeated-measures ANOVA used to compare deterioration time course from 12...
Abstract Astrocytes exert adverse effects on the brains of individuals with Down syndrome (DS). Although a neurogenic-to-gliogenic shift in fate-specification step has been reported, mechanisms and key regulators underlying accelerated proliferation astrocyte precursor cells (APCs) DS remain elusive. Here, we established human isogenic cell line panel based DS-specific induced pluripotent stem cells, XIST -mediated transcriptional silencing system trisomic chromosome 21,...
<h3>Objective</h3> To assess lung function at 8 years old in extremely low birthweight (ELBW) survivors and to identify perinatal determinants associated with impaired function. <h3>Design</h3> Retrospective cohort study. <h3>Setting</h3> Level III neonatal intensive care unit. <h3>Patients</h3> ELBW born 1990–2004 available spirometry were studied. Children excluded if they had a Wechsler Intelligence Scale for Third Edition full IQ <70. <h3>Main outcome measures</h3> Multivariate...
Background Outcomes of prenatal covariate-adjusted outborn very-low-birth-weight infants (VLBWIs) (≤1500 g) remain uncertain. Objective To compare morbidity and mortality between inborn VLBWIs. Design Observational cohort study using inverse-probability-of-treatment weighting. Setting Neonatal Research Network Japan. Patients Singleton VLBWIs with no major anomalies admitted to a neonatal intensive care unit from 2012 2016. Methods Inverse-probability-of-treatment weighting propensity scores...
Chromosome abnormalities induces profound alterations in gene expression, leading to various disease phenotypes. Recent studies on yeast and mammalian cells have demonstrated that aneuploidy exerts detrimental effects organismal growth development, regardless of the karyotype, suggesting aneuploidy-associated stress plays an important role pathogenesis. However, whether how this effect alters cellular homeostasis long-term features human are not fully understood. Here, we aimed investigate...
Objective To assess the association between gestational age classification at birth and risk of neurodevelopmental impairments 3 years. Design Cohort study using Japan Environment Children’s Study database. Patients A total 86 138 singleton children born without physical abnormalities 32–41 weeks gestation enrolled January 2011 March 2014. Main outcome measures Neurodevelopmental impairment, evaluated Ages Stages Questionnaire (third edition). Methods Logistic regression analysis was used to...
Abstract Eukaryotic genomes are organised into complex higher-order structures within the nucleus, and three-dimensional arrangement of chromosomes is functionally important for global gene regulation. The existence supernumerary chromosome 21 in Down syndrome may perturb nuclear architecture at different levels, which normally optimised to maintain physiological balance expression. However, it has not been clearly elucidated whether how aberrant configuration affects activities. To...
Abstract Individuals with Down syndrome (DS) commonly show unique pathological phenotypes throughout their life span. Besides the specific effects of dosage-sensitive genes on chromosome 21, recent studies have demonstrated that gain a exerts an adverse impact cell physiology, regardless karyotype. Although dysregulated transcription and perturbed protein homeostasis are observed in common human fibroblasts trisomy 18, 13, whether how this aneuploidy-associated stress acts other lineages...
Abstract Infantile liver failure syndrome type 1 (ILFS1) is a recently recognized autosomal recessive disorder caused by deleterious mutations in the leucyl‐tRNA synthetase gene ( LARS1 ). The enzyme responsible for incorporation of amino acid leucine during protein polypeptide synthesis. Individuals with typically show from infancy to early childhood periods illness or other physiological stress. While 25 patients 15 families ILFS1 have been reported literature, histological reports autopsy...
Objective To assess the association between gestational age at birth and risk of growth failure respiratory symptoms 3 years age. Design Cohort study using Japan Environment Children’s Study database. Patients A total 86 158 singleton infants born without physical abnormalities 32–41 weeks gestation were enrolled January 2011 March 2014. Main outcome measures Growth (weight <10th percentile height percentile) (asthma wheezing) Methods Logistic regression analysis was used to evaluate in...
<b>Objective</b> The aim of this article is to evaluate the accuracy, precision, and safety transcutaneous carbon dioxide tension (TcPCO<sub>2</sub>) monitoring at different electrode temperatures in preterm infants early postnatal period. <b>Study Design</b> A total 26 neonates with a median birth weight 974 g (432–1,694 g) gestational age 28.0 weeks (26.1–31.3 weeks) were studied first 5 days life. 252 simultaneous pairs (TcPCO<sub>2</sub> arterial [PaCO<sub>2</sub>]) analyzed 38, 39, 40°C...
To assess effects of neonatal transport on transient tachypnea the newborn (TTN) in outborn term neonates.This retrospective cohort study included 66 neonates diagnosed with TTN and transported to Osaka Women's Children's Hospital intensive care unit between January 2003 March 2018. A multivariate logistic regression analysis identified perinatal factors associated adverse short-term outcomes defined as mechanical ventilation >48 hours, continuous positive airway pressure >72 pulmonary...
Abstract Internal hernia through a mesenteric defect, called hernia, is an uncommon cause of acute intestinal obstruction in newborns. Strangulated results necrosis or perforation and progressive deterioration with fatal outcome, especially when it occurs low‐birthweight infants. We report two very ( VLBW ) infants, who presented related to defect. The initial diagnosis was meconium those cases, which common bowel occurring Correct difficult these cases because rapid non‐specific...
Abstract This study aimed to evaluate the association of neonatal transfer with risk neurodevelopmental outcomes at 3 years age. Data were obtained from Japan Environment and Children’s Study. A general population 103,060 pregnancies 104,062 fetuses was enrolled in 15 Regional Centers between January 2011 March 2014. Live-born singletons various gestational ages, including term infants, without congenital anomalies who followed up until included. Neurodevelopmental impairment assessed using...
Residual levels of 12 solvents in 87 natural food additives (66 samples colours, 19 antioxidants and two preservatives) collected between 1997 1999 were determined by automated head-space GC using FID, with a porouspolymer (PLOT) column. Calibration curves prepared the method standard addition. Confirmation was manually injected mass spectrometric detection. 1,2-Dichloroethane found turmeric colour (natural colour) at concentrations 8.6 µg g-1, but not 1998 1999. Hexane three dunaliella...
This study aimed to describe postnatal physiological changes in maximum values of peak electrical activity the diaphragm (Edi) extremely preterm infants during period.The amplitude and frequency neural sigh are different at each postmenstrual age infants.A retrospective, observational study.Edi were evaluated 14 with neurally-adjusted ventilatory assist.Data Edi minimum collected from a ventilator. Edi-sigh was defined as value that more than twice large median week patient. The Edi-sigh,...
Objective The study aimed to evaluate the association between bronchopulmonary dysplasia (BPD) development at 36 weeks' postmenstrual age (PMA) and Gram-negative bacteria in tracheal aspirate cultures among extremely preterm infants. Study Design This has a retrospective cohort. Patients were 155 infants aged less than or equal 26 gestational weeks who admitted neonatal intensive care unit of Osaka Women's Children's Hospital from 2009 2018. Primary outcome was respiratory outcomes expressed...
In Japan, the definition and classification of neonatal chronic lung disease (CLD) used for its diagnosis are a combination those in Japan abroad.To clarify current state CLD diagnosis, questionnaire survey was conducted.Half patients medical centers included study were diagnosed with real time, while other half after discharge. addition, approximately 70% facilities, made discussions various among teams. 80% centers, chest radiography evaluated by multiple doctors. Furthermore, some X-rays...