A5030253791- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Magnetic confinement fusion research
- Coronary Artery Anomalies
- Neonatal Respiratory Health Research
- Kawasaki Disease and Coronary Complications
- Hormonal Regulation and Hypertension
- Cardiac Structural Anomalies and Repair
- Congenital Diaphragmatic Hernia Studies
- Ionosphere and magnetosphere dynamics
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Blood Pressure and Hypertension Studies
- Infant Nutrition and Health
- Neuroscience and Neuropharmacology Research
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Superconducting Materials and Applications
- Congenital Heart Disease Studies
- Cardiovascular Disease and Adiposity
- Mechanical Circulatory Support Devices
- Nitric Oxide and Endothelin Effects
- Vascular Procedures and Complications
- Peripheral Artery Disease Management
Japanese Red Cross Society Kyoto Daini Hospital
2024-2025
Osaka Women's and Children's Hospital
2018-2025
Kyoto first Red Cross hospital
2015-2024
National Institutes for Quantum Science and Technology
2016-2020
Oak Ridge National Laboratory
2020
National Institute for Fusion Science
2020
Universidad Carlos III de Madrid
2020
Fusion Academy
2019
Fusion (United States)
2019
Osaka Medical Center for Cancer and Cardiovascular Diseases
2007-2017
Objectives: The present study examined the possibility that intracellular ATP levels dictate whether hypoxic cardiac myocytes die by apoptosis or necrosis. Background: Although and necrosis may appear to be distinct forms of cell death, recent studies suggest two represent different outcomes a common pathway. In ischemic myocardium, appears early, while energy stores are presumably still available, followed only later Methods: Neonatal rat were exposed continuous hypoxia, during which...
Background— Aldosterone has recently attracted considerable attention for its involvement in the pathophysiology of heart failure, which apoptotic cell loss plays a critical role. This study examined whether aldosterone directly induces myocyte apoptosis via specific receptors. Methods and Results— Neonatal rat cardiac myocytes were exposed to (10 −8 10 −5 mol/L). Nuclear staining with Hoechst 33258 showed that induced dose- time-dependent fashion. Treatment mol/L significantly increased...
Abstract Background: A nationwide survey on neonatal surgery conducted by the Japanese Society of Pediatric Surgeons has demonstrated that mortality intestinal perforation risen over past 15 years. The incidence in extremely low‐birthweight (ELBW) neonates been increasing as more ELBW survive and live‐birth rate increased. In contrast to necrotizing enterocolitis (NEC) focal (FIP), pathogenesis meconium‐related ileus, defined functional bowel obstruction characterized delayed meconium...
To assess lung function and long-term respiratory outcomes in extremely low birth weight (ELBW) survivors.ELBW, especially with complications the neonatal period, affects at a later age.Longitudinal retrospective study.Lung was evaluated 89 ELBW survivors (at ages 8 12) or without history of bronchopulmonary dysplasia (BPD) bubbly/cystic appearance period.FVC, FEV1 , FEF50 FEF75 were measured using spirometry. Two-way repeated-measures ANOVA used to compare deterioration time course from 12...
BACKGROUND: Limited large-scale, real-world data exist on the prevalence and clinical impact of discordance between fractional flow reserve (FFR) nonhyperemic pressure ratios (NHPRs). METHODS: The J-PRIDE registry (Clinical Outcomes Japanese Patients With Coronary Artery Disease Assessed by Resting Indices Fractional Flow Reserve: A Prospective Multicenter Registry) prospectively enrolled 4304 lesions in 3200 patients from 20 centers. were classified into FFR+/NHPR−, FFR−/NHPR+, FFR+/NHPR+,...
Abstract Background No echocardiographic model, to the best of our knowledge, has been established predict future need for patent ductus arteriosus (PDA) surgery. This study aimed develop a novel predictive score (PLASE score) anticipating PDA surgery using PLASE database. Methods The included infants with gestational age (GA) < 30 weeks were allocated derivation and validation groups (2:1). Logistic regression models constructed utilizing three clinical indices measured at 3 days as...
<h3>Objective</h3> To assess lung function at 8 years old in extremely low birthweight (ELBW) survivors and to identify perinatal determinants associated with impaired function. <h3>Design</h3> Retrospective cohort study. <h3>Setting</h3> Level III neonatal intensive care unit. <h3>Patients</h3> ELBW born 1990–2004 available spirometry were studied. Children excluded if they had a Wechsler Intelligence Scale for Third Edition full IQ <70. <h3>Main outcome measures</h3> Multivariate...
Recent studies have suggested that apoptosis and necrosis share common features in their signaling pathway requires intracellular ATP for its mitochondrial/apoptotic protease-activating factor-1 suicide cascade. The present study was, therefore, designed to examine the role of energy levels determining form cell death cardiac myocytes. Neonatal rat myocytes were first incubated 1 h glucose-free medium containing oligomycin achieve metabolic inhibition. cells then another 4 similar...
Background The prevalence and clinical manifestations of acute myocardial infarction (AMI) in young patients Japan have not been fully investigated. Methods Results In the present study, 1651 AMI were enrolled AMI-Kyoto Multi-Center Risk Study between January 2000 June 2004. Of these, background, risk factors, angiographic findings, results primary percutaneous coronary intervention (PCI) in-hospital outcomes for 27 <40 (young group), 338 non-young 60≤, <70 years old (non-young group)...
Abstract Background : Although burr entrapment is a rare complication of the Rotablator, it extremely difficult to retrieve fixedly entrapped without surgical procedure. Case Report An 84‐year‐old male with effort angina had heavily calcified coronary trees as well severe stenosis in mid LCx, and moderate proximal LMT. We planned perform rotational atherectomy LCx lesions. Using 7 Fr Q‐curve guiding catheter Rotawire floppy, we began ablate using 1.5‐mm at 200,000 rpm. Because could not pass...
Cardiorenal anemia syndrome has recently been receiving greater attention; however, data regarding the relationship between chronic kidney disease (CKD)/anemia on presentation and in-hospital outcome in patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI) are still limited Japan.A total of 1,447 PCI-treated AMI were classified into 4 groups according to presence CKD and/or hospital admission (with CKD/with n = 222, CKD/without 299,...
Ureaplasma spp. cause several disorders, such as nongonococcal urethritis, miscarriage, and preterm delivery with lung infections in neonates, characterized by pathological chorioamnionitis the placenta. Although reports on antibiotic resistance are rise, quinolone-resistant Japan limited. The purpose of this study was to determine susceptibilities five quinolones urealyticum parvum isolated from perinatal samples characterize quinolone resistance-determining regions gyrA, gyrB, parC, parE...
Context Basic studies have shown that brain-derived neurotrophic factor (BDNF) has critical roles in the survival, growth, maintenance, and death of central peripheral neurons, while it is also involved regulation autonomic nervous system. Furthermore, recent clinical suggested potential role plasma BDNF circulatory Objective We investigated mutual relationships among BDNF, patterns nocturnal blood pressure changes (dippers, non-dippers, extra-dippers, reverse-dippers), cardiac function as...
Myocardial ischemia–reperfusion injury involves necrosis and apoptosis. The inhibition of angiotensin-converting enzyme (ACE) has been reported to suppress infarct size. In this study, it was investigated whether an ACE inhibitor affected myocardial apoptosis apoptosis-related proteins in rats with experimental infarction. Anesthetized Sprague-Dawley were divided into four groups. Group I underwent 30 minutes left coronary artery occlusion followed by 24 hours reperfusion (control group); II...