A5103204228- Parathyroid Disorders and Treatments
- Bone health and treatments
- Heart Rate Variability and Autonomic Control
- Vitamin D Research Studies
- Bone health and osteoporosis research
- Sleep and related disorders
- Blood Pressure and Hypertension Studies
- Magnesium in Health and Disease
- Folate and B Vitamins Research
- Fibroblast Growth Factor Research
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Metabolism, Diabetes, and Cancer
- Biochemical and Molecular Research
- Pituitary Gland Disorders and Treatments
- Regulation of Appetite and Obesity
- Heart rate and cardiovascular health
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Syndromes and Imprinting
- Meningioma and schwannoma management
- Heterotopic Ossification and Related Conditions
- Mast cells and histamine
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Kruppel-like factors research
Osaka Metropolitan University
2022-2023
Osaka City University
2008-2022
Hyogo Medical University
2011-2018
Kyoto University
2016
Summary Background Serum tartrate‐resistant acid phosphatase (TRACP) 5b levels were assessed in predialysis patients with chronic kidney disease (CKD). The aim of the study was to establish usefulness a new assay for TRACP5b assessing bone turnover these patients. Methods concentrations two resorption markers, and N‐terminal cross‐linking telopeptide type I collagen (NTX); formation specific alkaline (bone ALP) intact osteocalcin (OC[1–49]); PTH measured 98 CKD Results Log serum other...
Receptor for advanced glycation end products (RAGE) has been shown to be involved in adiposity as well atherosclerosis even nondiabetic conditions. In this study, we examined mechanisms underlying how RAGE regulates and insulin sensitivity. overexpression 3T3-L1 preadipocytes using adenoviral gene transfer accelerated adipocyte hypertrophy, whereas inhibitions of by small interfering RNA significantly decrease hypertrophy. Furthermore, double knockdown high mobility group box-1 S100b, both...
It has been shown that visceral fat accumulation is associated with autonomic dysfunction, though the precise mechanism remains unclear. A recent basic study found leptin can directly modulate function through dorsomedial hypothalamus in relation to obesity. Here, we investigated mutual relationships among plasma leptin, accumulation, and cardiac dysfunction patients type 2 diabetes. This cross-sectional included 100 diabetic patients, age- gender-matched non-diabetic cardiovascular risk...
Context Basic studies have shown that brain-derived neurotrophic factor (BDNF) has critical roles in the survival, growth, maintenance, and death of central peripheral neurons, while it is also involved regulation autonomic nervous system. Furthermore, recent clinical suggested potential role plasma BDNF circulatory Objective We investigated mutual relationships among BDNF, patterns nocturnal blood pressure changes (dippers, non-dippers, extra-dippers, reverse-dippers), cardiac function as...
Abstract Macro thyroid-stimulating hormone (TSH) has been reported to be associated with seasonality and regulated by changes in day length rodents, different from free TSH. In the present study, we investigated structural differences between macro TSH levels human serum, as well association of sleep quality. We enrolled 314 patients registered Hyogo Sleep Cardio-Autonomic Atherosclerosis (HSCAA) study. quality shown actigraphy, physical activity, percent all closely matched subjects were...
Background Sleep quality and awake physical activity are important behavioral factors involved in the occurrence of cardiovascular diseases, potentially through nocturnal blood pressure (BP) changes. However, impacts quantitatively measured sleep on BP fluctuation, their relationships with several candidate causal for hypertension not well elucidated. Methods This cross-sectional study included 303 patients registered HSCAA study. Measurements determined parameters obtained by actigraph,...
Brain-derived neurotrophic factor (BDNF) has been shown to have protective effects against cardiovascular diseases and death through neural non-neural pathways via tropomyosin-related kinase B signaling. However, it is not known whether plasma BDNF concentration a predictor of chronic kidney disease (CKD).This study was conducted as prospective cohort part the Hyogo Sleep Cardio-Autonomic Atherosclerosis.We measured in 324 patients without CKD, defined an estimated glomerular filtration rate...
Parathyroid hormone (PTH) increases fibroblast growth factor 23 (FGF23), mediated both by protein kinase A (PKA) and Wnt signaling, decreases expression of sclerostin, a antagonist derived from osteocytes. Patients with primary hyperparathyroidism (PHPT) have lower serum sclerostin levels than healthy controls, consistent the idea SOST downregulation PTH. Nevertheless, relationship between FGF23 in PHPT is still unclear. We examined this issue mouse model PHPT. mice had increased decreased...
ABSTRACT Higher serum phosphorus (Pi) increases the risk for chronic kidney disease (CKD). It was reported that a single administration of denosumab or zoledronate significantly suppressed Pi levels as well those bone resorption markers in serum. Also, previous evidences suggest link between anti-resorptive therapy and vasoprotective/renoprotective effects through mechanisms remain unexplored. The aim this study is to assess renoprotective effect involvement denosumab-induced reduction...
Patients with chronic kidney disease (CKD) need to follow phosphorus-restricted diets because impaired phosphorus excretion induces hyperphosphatemia in CKD, which increases mineral and bone disorders, cardiovascular diseases, mortality; however, hypophosphatemic osteomalacia caused by CKD patients has not been described. We report here a patient whom hypophosphatemia resulted of deficiency from strict diet. The (CKD stage G3b; estimated glomerular filtration rate, 31.5 mL/min/1.73 m2)...
Excess fibroblast growth factor 23 (FGF23) causes hypophosphatemic osteomalacia, which is associated with impaired bone matrix mineralization. Tumor-induced osteomalacia (TIO) a rare paraneoplastic syndrome caused by over-secretion of FGF23 from tumor. Burosumab, fully human monoclonal antibody activities against FGF23, was initially approved in Japan before the rest world for treatment FGF23-associated TIO. We report here patient 15-year history non-remission TIO treated conventional...
Anaplastic thyroid carcinoma is a rare disease, and cases associated with eosinophilia are even rarer. We herein report case of anaplastic accompanied by remarkable uncontrollable eosinophilia. A 71-year-old man was diagnosed end-stage carcinoma. Throughout the aggressive clinical course cancer, dramatically progressed became extremely refractory to steroid treatment. measured serum levels hematopoietic cytokines potentially involved in eosinophilia, including granulocyte-macrophage...
Serum concentration of soluble interleukin-2 receptor (sIL-2R) has been established as a reliable marker T-lymphocyte activation. However, there have no reports describing the relationship between serum sIL-2R and painless thyroiditis.We report case 76-yr-old female with significant temporary increase concomitant thyroiditis.The patient was diagnosed malignant lymphoma at age 73. After 6 cycles CHOP-R complete remission induced recurrence observed up to 3.5 years. At 76 years age, she...
Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a condition of endogenous hypercortisolism sustained by an extrapituitary ACTH-secreting tumor. Olfactory neuroblastoma (ONB) rare malignant neoplasm the sinonasal tract and derived from olfactory epithelium. Because paranasal sinus not common site EAS, development ONB in patients with EAS rare. We herein report first known case acquirement ACTH production during clinical course as proven immunohistochemistry. A 50-year-old man...