A5052569675- Parathyroid Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Treatment and Management
- Cardiovascular Health and Disease Prevention
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Dialysis and Renal Disease Management
- Diabetes Management and Research
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Chronic Kidney Disease and Diabetes
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Gout, Hyperuricemia, Uric Acid
- Cardiovascular Disease and Adiposity
- Liver Disease Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Vitamin D Research Studies
- Blood Pressure and Hypertension Studies
- Adipose Tissue and Metabolism
- Anesthesia and Pain Management
- Cerebrovascular and Carotid Artery Diseases
- Fatty Acid Research and Health
- Pancreatitis Pathology and Treatment
- Nutrition and Health in Aging
- Peripheral Artery Disease Management
Osaka Metropolitan University
2022-2024
Tokyo Metropolitan University
2024
Osaka City University
2013-2022
Joslin Diabetes Center
2007-2017
Tsukuba University of Technology
2017
Waseda University
2017
University of Occupational and Environmental Health Japan
2004-2016
Imari Arita Kyoritsu Hospital
2016
Faculty (United Kingdom)
2014
Harvard University
2012
Obesity is characterized by hyperinsulinemia, hyperleptinemia, and an increase in islet volume. While the mechanisms that hasten onset of diabetes obese individuals are not known, it possible adipose-derived hormone leptin plays a role. In addition to its central actions, exerts biological effects acting peripheral tissues including endocrine pancreas. To explore impact disrupting signaling pancreas on β cell growth and/or function, we created pancreas-specific receptor (ObR) KOs using mice...
OBJECTIVE—To investigate the impact of glycemic control on survival diabetic subjects with end-stage renal disease (ESRD) starting hemodialysis treatment. RESEARCH DESIGN AND METHODS—This single-center prospective observational study enrolled 150 ESRD (109 men and 41 women; age at initiation, 60.5 ± 10.2 years) start between January 1989 December 1997. The were divided into groups according to their level inclusion as follows: good HbA1c <7.5%, n = 93 (group G), poor ≥7.5%, 57 P); was...
OBJECTIVE—To investigate whether the quantitative insulin sensitivity check index (QUICKI) and reciprocal of homeostasis model assessment (1/HOMA-IR) derived from fasting plasma glucose level are excellent surrogate indices resistance in both normal range-weight moderately obese type 2 diabetic healthy subjects. RESEARCH DESIGN AND METHODS—The association between QUICKI or 1/HOMA-IR assessed by euglycemic-hyperinsulinemic clamp (clamp-IR) was investigated 121 29 subjects recruited among 120...
To investigate the impact of glycemic control during regular hemodialysis on survival diabetic patients with chronic kidney disease (CKD) in a longitudinal observational study.A total 114 CKD at Inoue Hospital (Suita, Japan) were surveyed from May 1995 to December 2002 (survey period 45.5 +/- 29.3 [means SD] months). All subjects categorized into three groups by mean HbA(1c) (A1C) level 3-month preceding entry, as follows: good (A1C <6.5%, 5.7 0.4%, n = 34), fair (6.5 <or= A1C < 8.0%, 7.2...
Uric acid has both antioxidant and pro-oxidant properties in vitro by scavenging production of reactive oxygen species (ROS). This cross-sectional study examined whether uric possesses effects on oxidative stress under physiological conditions independent xanthine oxidoreductase (XOR), which is involved ROS production. Serum level was measured, while plasma XOR activity determined using our high-sensitive assay 192 participants (91 males, 101 females) who underwent health examinations were...
During the ongoing coronavirus disease 2019 (COVID-19) pandemic, it is critical to ensure safety of COVID-19 vaccines. We herein report a 51-year-old Japanese woman who developed acute-onset type 1 diabetes with diabetic ketoacidosis six weeks after receiving first dose messenger ribonucleic acid (mRNA) vaccine. Laboratory tests indicated exhaustion endogenous insulin secretion, positive result for autoantibody, and latent thyroid autoimmunity. Human leukocyte antigen typing was homozygous...
Angiogenic response is impaired in diabetes. Here, we examined the involvement of receptor for advanced glycation end products (RAGE) diabetes-related impairment angiogenesis vivo. Angiogenesis was determined reconstituted basement membrane protein (matrigel) plugs containing vascular endothelial growth factor (VEGF) implanted into nondiabetic or insulin-deficient diabetic wild-type RAGE−/− mice. The total, endothelial, and smooth muscle (or pericytes) cells matrigel were significantly...
Receptor for advanced glycation end products (RAGE) has been shown to be involved in adiposity as well atherosclerosis even nondiabetic conditions. In this study, we examined mechanisms underlying how RAGE regulates and insulin sensitivity. overexpression 3T3-L1 preadipocytes using adenoviral gene transfer accelerated adipocyte hypertrophy, whereas inhibitions of by small interfering RNA significantly decrease hypertrophy. Furthermore, double knockdown high mobility group box-1 S100b, both...
Fulminant type 1 diabetes is characterized by a rapid progression of insulin deficiency triggered viral infection. Here, we report case 45-year-old Japanese woman with fulminant that developed 8 days after receiving messenger ribonucleic acid vaccine against severe acute respiratory syndrome coronavirus 2. She had been healthy and no symptoms suggestive infection before the vaccination. Laboratory tests showed exhaustion secretion negative results for islet autoantibodies. Human leukocyte...
Aerobic exercise is a generally accepted therapeutic strategy for type 2 diabetes because it has beneficial effects not only on glycemic profile, but also reducing metabolic risk factors cardiovascular diseases including insulin resistance. Previous studies (1,2) have showed the of moderate-intensity improvement sensitivity. Adiponectin, protein secreted by adipose tissue, presents lower plasma levels in subjects with obesity or and closely correlated degree resistance assessed glucose...
The purpose of the study was to investigate whether quantitative insulin sensitivity check index (QUICKI) and reciprocal homeostasis model assessment (1/HOMA-IR) are excellent surrogate indexes resistance in type 2 diabetic patients with various ranges fasting plasma glucose. One hundred eight were divided into tertiles according levels glucose (FPG) [T1: 4.2 < or = FPG (mmol/liter) 6.5, n 36; T2: 6.5 8.1, T3: 8.1 11.1, 36]. association between QUICKI 1/HOMA-IR assessed by euglycemic...
ABSTRACT Background Fetuin-A inhibits precipitation of calcium-phosphate crystals by forming calciprotein particles (CPP). A novel T50 test, which measures transformation time from primary to secondary CPP, is an index for calcification propensity. Both lower fetuin-A and shorter levels were associated with cardiovascular disease (CVD) risk in patients chronic kidney (CKD). Extremely high CVD death advanced CKD consists high-incidental event mortality after event. To date, it unclear whether...
Atherosclerosis and arteriosclerosis are mainly caused by the dysfunction of arterial components, namely, vascular endothelial cells, smooth muscle extracellular matrix. Endothelial is well established as a predictive surrogate marker cardiovascular events; however, little known regarding clinical implications for disease microangiopathy. In present study, we aimed to clarify association with micro-/macroangiopathy conventional risk factors in 181 type 2 diabetic patients (T2DM; age ± SD, 64...
Lipopolysaccharide (LPS)-binding protein (LBP) is an acute-phase reactant that mediates immune responses triggered by LPS. Recent evidence indicates the association of circulating LBP levels with obesity, diabetes, and cardiovascular diseases. In this study, we aimed to investigate relationship between serum arterial stiffness in patients type 2 diabetes.A total 196 including 101 men 95 women, were enrolled cross-sectional study. Fasting determined enzyme-linked immunosorbent assay. Arterial...
The adipocyte-derived hormone leptin plays a key role in the regulation of appetite and body weight. Recent studies have suggested that is also involved pathogenesis obesity-related atherosclerosis cardiovascular disease. In this study, we investigated association plasma levels with vascular endothelial function lean overweight patients type 2 diabetes. One hundred seventy-one diabetic patients, which 85 were (body mass index (BMI) ≥ 25 kg/m2), enrolled cross-sectional study. Plasma...
OBJECTIVE—Hyperglycemia and hypertension are known to be risk factors for the development of proteinuria in patients with diabetes. Little is known, however, about predictors progression renal failure diabetic patients. RESEARCH DESIGN AND METHODS—We investigated affecting by measuring doubling serum creatinine (s-Cr) as an end point a cohort 85 type 2 chronic insufficiency/failure (s-Cr &gt;1.5 &lt;3.7 mg/dl, 61 ± 11 years old, 51 men 34 women, mean s-Cr 2.3 0.6 mg/dl). RESULTS—The...