A5079064356- Gout, Hyperuricemia, Uric Acid
- Alcohol Consumption and Health Effects
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Nutrition and Health in Aging
- Folate and B Vitamins Research
- Regulation of Appetite and Obesity
- Diabetes Management and Research
- Sleep and Wakefulness Research
- Diet, Metabolism, and Disease
- Parathyroid Disorders and Treatments
- Sleep and related disorders
- Eosinophilic Disorders and Syndromes
- Case Reports on Hematomas
- Metabolism and Genetic Disorders
- Bone and Joint Diseases
- Diabetes Treatment and Management
- Bone health and osteoporosis research
- Liver Disease and Transplantation
- Urticaria and Related Conditions
- HIV-related health complications and treatments
- Cardiovascular Disease and Adiposity
- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
Osaka Metropolitan University
2022-2024
Osaka City University
2008-2022
Hyogo Medical University
2011-2018
Kinki Central Hospital
2012
Uric acid has both antioxidant and pro-oxidant properties in vitro by scavenging production of reactive oxygen species (ROS). This cross-sectional study examined whether uric possesses effects on oxidative stress under physiological conditions independent xanthine oxidoreductase (XOR), which is involved ROS production. Serum level was measured, while plasma XOR activity determined using our high-sensitive assay 192 participants (91 males, 101 females) who underwent health examinations were...
We reviewed lifestyle factors that influence serum uric acid levels and risk of gout flare, how to improve their deleterious effects. Since obesity increases weight gain risk, reduction by daily exercise limiting intake excess calories is recommended. However, strenuous exercise, which causes adenine nucleotide degradation; starvation, decreases excretion; dehydration may raise the level in trigger gout. Increased purine-rich foods, such as meat seafood, associated with increased gout,...
Hyperuricemia has been reported to affect renal hemodynamics. In a recent study, both low and high levels of serum uric acid (SUA) were found be associated with loss kidney function. The goal this study was evaluate the relationship between SUA intrarenal hemodynamic parameters in healthy subjects, using plasma clearance para-aminohippurate (CPAH) inulin (Cin). Renal glomerular hemodynamics evaluated by simultaneous measurements CPAH Cin 48 subjects (54.6 ± 13.4 yr). Intrarenal parameters,...
Abstract Background Omentin and adiponectin are among the anti-inflammatory anti-atherogenic adipokines that have potentially beneficial effects on cardiovascular disorders. Recent studies indicate a paradoxical relationship between mortality across many clinical settings including type 2 diabetes. In this study, we characterized features of diabetes patients with increased levels examined association omentin atherosclerosis in those patients. Methods The subjects were 413 Fasting plasma...
Abstract Xanthine oxidoreductase (XOR) inhibitor administration reduces uric acid and reactive oxygen species (ROS) production, also lowers blood pressure (BP). However, the associations of plasma XOR activity, level, oxidative stress levels with BP remain unclear. This cross-sectional study included 156 subjects (68 males, 88 females) registered in MedCity21 health examination registry without anti-hypertensive or anti-hyperuricemic agent administration. Plasma activity was measured using...
Acute and chronic insomnia can exacerbate type 2 diabetes mellitus (T2DM). We investigated suvorexant (an anti-insomnia drug that targets the orexin system) effects on sleep architecture glucose metabolism in T2DM patients with insomnia.This 7 day open-label, single-arm, intervention trial included 18 subjects insomnia. After 1 acclimatization, daily levels, architecture, autonomic nervous function were evaluated by continuous monitoring (CGM), single-channel electroencephalography,...
Background Malnutrition and sarcopenia are frequently observed in patients undergoing maintenance hemodialysis (MHD). To elucidate whether malnutrition is associated with those cases, the relationship of nutritional status was investigated. Methods Nutritional assessed using a risk index (NRI) developed for MHD. This retrospective cross-sectional study included 315 MHD (199 males, 116 females), who were divided into low-risk (score 0–7) medium-/high-risk 8–13) groups. Sarcopenia severe...
Xanthine oxidoreductase activity (XOR-a) plays an important role as a pivotal source of reactive oxygen species. In the present study, we investigated factors associated with plasma XOR-a in 163 hemodialysis patients (age 67.3 ± 10.9 years; 89 males and 74 females), using newly established, highly-sensitive assay based on [13C2,15N2] xanthine liquid chromatography/triple quadrupole mass spectrometry. Plasma glucose serum uric acid levels correlated significantly positively XOR-a. multiple...
Gout results from elevated serum urate (SU) levels, or hyperuricemia, and is a globally widespread increasingly burdensome disease. Recent studies have illuminated the pathophysiology of gout/hyperuricemia its epidemiology, diagnosis, treatment, complications. The genetic involvement transporters enzymes also proven. URAT1, molecular therapeutic target for gout/hyperuricemia, was initially derived research into hereditary renal hypouricemia (RHUC). RHUC often accompanied by complications...
Abstract Background We developed a novel high-sensitive assay for plasma xanthine oxidoreductase (XOR) activity that is not affected by the original serum uric acid level. However, association of XOR with level has been fully examined. Methods This cross-sectional study included 191 subjects (91 males, 100 females) registered in MedCity21 health examination registry. Plasma was determined using our [ 13 C 2 , 15 N ] and liquid chromatography/triple quadrupole mass spectrometry. Serum levels...
Background . Higher levels of uric acid production have been reported in individuals with visceral fat obesity, and obesity is known to enhance xanthine oxidoreductase (XOR) activity, although the precise mechanism remains unclear. We investigated associations area (VFA), serum adiponectin level, insulin resistance plasma XOR activity using our novel highly sensitive assay based on [ 13 C 2 , 15 N ] liquid chromatography/triple quadrupole mass spectrometry. Methods This cross-sectional study...
Abstract Aims/Introduction A soluble form of the leptin receptor (soluble Ob‐R) in circulation regulates leptin's bioactivity, and is inversely associated with body adiposity circulating levels. However, no study has examined clinical impact Ob‐R on glucose metabolism diabetes. The present aimed to investigate association plasma levels insulin resistance pancreatic β‐cell function patients type 2 Materials Methods total 289 Japanese diabetes were included study. Fasting measured by...
Poor sleep quality is associated with obesity and diabetes. The adipocyte-derived hormone, leptin, was recently shown to underlie the link between abnormal obesity. We aimed investigate association leptin in type 2 diabetes patients.In present cross-sectional study, we studied 182 patients, among whom 113 were diagnosed (body mass index ≥25 kg/m2 ). Fasting plasma levels measured, architecture assessed using single-channel electroencephalography.Using unadjusted analyses, obese but not their...
Xanthine oxidoreductase (XOR) inhibition reduces reactive oxygen species (ROS) production and enhances adenosine triphosphate (ATP) synthesis. We investigated the protective effects of XOR inhibitor treatment on sarcopenia, frequently observed in patients undergoing hemodialysis (HD), which increased ROS ATP shortage are known to be involved.This retrospective cross-sectional study included 296 HD patient (203 males, 93 females). Muscle mass, physical performance, muscle strength were...
Background: Urate-lowering drugs (ULDs) have been approved for treatment of asymptomatic hyperuricemia and gout in Japan. Although serum urate levels rates onset are known to seasonal variations, no survey results regarding the seasonality ULD prescriptions reported. Methods: A large-scale database medical claims Japan filed between January 2019 December 2022 was accessed. In addition total size recorded population each month examined, numbers patients every with newly prescribed ULDs were...
In primary aldosteronism (PA), aldosterone could affect glomerular hemodynamics by elevating renal vascular resistance and capillary pressure. However, the relationship between plasma concentrations (PAC) including efferent arteriolar (Re), afferent (Ra) in humans is still unclear. The aim of this study was to investigate relationships PAC with intraglomerular hemodynamic parameters patients PA.
C-reactive protein (CRP) is associated with increased risk for myocardial infarction, atherosclerosis, and peripheral artery diseases, while serum uric acid level suggested to be independently an of cardiovascular mortality. Accordingly, investigate whether hyperuricemia CRP, we compared CRP levels between healthy subjects patients gout. In addition, also examined benzbromarone has effects on in gout the expression messenger RNA hepatoma cell line HuH7.In first experiment, 40 males 43 male...
Osteoporosis is known to be intimately related sympathetic nerve activity. We examined the relationship of plasma leptin with cortical and trabecular bone components in patients type 2 diabetes mellitus.