A5009110869- Parathyroid Disorders and Treatments
- Bone health and treatments
- Glaucoma and retinal disorders
- Bone health and osteoporosis research
- Gallbladder and Bile Duct Disorders
- Ocular Surface and Contact Lens
- Thyroid Disorders and Treatments
- Vitamin D Research Studies
- Corneal surgery and disorders
- Bone and Joint Diseases
- Retinal Diseases and Treatments
- Fibroblast Growth Factor Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Medical Imaging and Pathology Studies
- Gout, Hyperuricemia, Uric Acid
- Esophageal and GI Pathology
- Dialysis and Renal Disease Management
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Genetic Syndromes and Imprinting
- Cardiovascular Health and Disease Prevention
- Thyroid Cancer Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Minimally Invasive Surgical Techniques
- Folate and B Vitamins Research
Tokyo Metropolitan University
2023-2024
Osaka Metropolitan University
2022-2024
Yazaki (United States)
2020-2024
Toyota Kosei Hospital
2023
Osaka City University
2012-2022
Kagoshima City Hospital
2018-2020
Kagoshima Medical Center
2019
University of Tsukuba
2015
Shibaura Institute of Technology
2013
Osaka Dental University
2007-2009
Uric acid has both antioxidant and pro-oxidant properties in vitro by scavenging production of reactive oxygen species (ROS). This cross-sectional study examined whether uric possesses effects on oxidative stress under physiological conditions independent xanthine oxidoreductase (XOR), which is involved ROS production. Serum level was measured, while plasma XOR activity determined using our high-sensitive assay 192 participants (91 males, 101 females) who underwent health examinations were...
We retrospectively investigated the relationship between Schlemm's canal incision length and results of ab interno gonioscopy-assisted transluminal suture trabeculotomy (GATST) with/without cataract surgery in open-angle glaucoma patients at Tsukazaki Hospital from 2018-2021. The study included 113 eyes 76 (age: 70.0 ± 10.8 years; female/male: 43 [56.6%]/33 [43.4%]). GATST with without was performed on 87 (phakia) [77.0%] 26 (pseudophakia) [23.0%], respectively; 102 [90.3%] had primary...
Abstract Background This study investigated the agreement between a new rebound tonometer, IC200, and IcarePRO Goldmann applanation tonometry (GAT). Methods was prospective cross-sectional study. We measured intraocular pressure (IOP) in 145 eyes of glaucoma patients sitting position using GAT, IcarePRO, IC200. IC200 measurements were also obtained supine position. measurement performed two modes: single six (IC200-single) automatic (IC200-continuous) six-measurements mode. Results All...
Subclinical hypothyroidism affects 5-15% of the general population, is especially prevalent in females, and may be associated with increased morbidity from cardiovascular disease, although it remains controversial. We recently reported a significant increase brachial-ankle pulse wave velocity (baPWV), parameter arterial stiffening an independent predictor events, subclinical without thyroiditis. The current study was performed to assess changes baPWV female autoimmune chronic thyroiditis...
The use of the PreserFlo microshunt is gaining popularity owing to its ease implantation and reduced need for postoperative intervention compared conventional trabeculectomy.
Cortical porosity is increasingly recognized as an important risk for fracture in DM patients. The present study demonstrated that decreased cortical thickness, assessed using a newly developed quantitative ultrasonic bone densitometry, significant factor vertebral fractures type 2 diabetes mellitus patients with stage 3 or higher chronic kidney disease, but not those without. (T2DM) well disease (CKD) whom serum parathyroid hormone (PTH) starts to increase. aimed clarify whether the...
ObjectiveInfection is related to a higher rate of hospitalization and subsequent death in patients undergoing hemodialysis. Limited data are available about factors associated with after for infection. Nutritional disorder also known as protein energy wasting profoundly poor consequences. The Geriatric Risk Index (GNRI) simple but useful nutritional screening tool predict mortality. We examined whether the GNRI could infection death.Design MethodsThis was prospective cohort study on...
Parathyroid hormone (PTH) increases fibroblast growth factor 23 (FGF23), mediated both by protein kinase A (PKA) and Wnt signaling, decreases expression of sclerostin, a antagonist derived from osteocytes. Patients with primary hyperparathyroidism (PHPT) have lower serum sclerostin levels than healthy controls, consistent the idea SOST downregulation PTH. Nevertheless, relationship between FGF23 in PHPT is still unclear. We examined this issue mouse model PHPT. mice had increased decreased...
We recently reported cases of adipsic hypernatremia caused by autoantibodies against the subfornical organ in patients with hypothalamic-pituitary lesions. This study aimed to clarify clinical features newly identified whose sera displayed immunoreactivity mouse organ.Observational cohort diagnosed Japan, United States, and Europe.The included 22 but without overt structural changes region congenital disease. Antibody response was determined using immunohistochemistry. The characteristics...
Aberrant expression of maspin protein related to DNA hypomethylation in the promoter region is frequently observed gallbladder carcinomas, whereas non-tumorous epithelium negative. We investigated patients with cholelithiasis.An immunohistochemical study was performed 69 cholelithiasis and 30 gastric cancer without cholelithiasis.Immunoreactivity for focal patchy regions epithelium. Positive immunoreactivity significantly associated presence intestinal metaplasia (p<0.05).The high incidence...
The uvea comprises the iris, ciliary body, and choroid. However, development of anterior part (iris body) in children is not yet fully elucidated. We investigated iris thickness (IT) using swept-source anterior-segment optical coherence tomography (ASOCT).In this retrospective, clinic-based study, we enrolled 41 (mean ± standard deviation: 6.8 3.3 years; range: 3-16; 17 males) with normal or mild refractive error. Horizontal scanning images ASOCT were analyzed temporal nasal angle areas. ITs...
ABSTRACT Higher serum phosphorus (Pi) increases the risk for chronic kidney disease (CKD). It was reported that a single administration of denosumab or zoledronate significantly suppressed Pi levels as well those bone resorption markers in serum. Also, previous evidences suggest link between anti-resorptive therapy and vasoprotective/renoprotective effects through mechanisms remain unexplored. The aim this study is to assess renoprotective effect involvement denosumab-induced reduction...
Abstract Objective To prospectively evaluate the heterogeneous appearance of thyroid gland, reflecting inflammation and destruction in euthyroid Hashimoto’s thyroiditis (HT), we investigated clinical utilities heterogeneity index (HI) [the coefficient variance (CV) ultrasonographic (US) intensities], focusing on anti-thyroid peroxidase antibodies (TPO-Ab), which represent not only disease activity but also subsequent HT. Methods Forty-four consecutive patients with HT [60.5 ± 2.7 years old...