A5088081197- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Vitamin D Research Studies
- Nutrition and Health in Aging
- Biomedical Research and Pathophysiology
- Pharmacological Effects and Toxicity Studies
- Renal Diseases and Glomerulopathies
- Vitamin K Research Studies
- Hemoglobinopathies and Related Disorders
- Erythropoietin and Anemia Treatment
- Obstructive Sleep Apnea Research
- Diabetes Treatment and Management
- Iron Metabolism and Disorders
- Renal function and acid-base balance
- Blood properties and coagulation
- Chronic Kidney Disease and Diabetes
- Cardiovascular Health and Disease Prevention
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Magnesium in Health and Disease
- Alkaline Phosphatase Research Studies
- Body Composition Measurement Techniques
- Genetic Syndromes and Imprinting
- Bone health and treatments
Shirasagi Hospital
2014-2024
Osaka City University
1992-2014
Osaka Hospital
2009-2010
Inoue Hospital
1991-2003
Asahikawa Medical College Hospital
1995
Nagoya University
1995
Yale University
1995
Sarcopenia has become a serious disorder in modern society. Chronic kidney disease requiring dialysis and diabetes are some of the disorders that accelerate onset progression sarcopenia. We, therefore, investigated prevalence sarcopenia patients undergoing hemodialysis (HD) confirmed impact mellitus (DM) on this population. This study included 308 whose muscle strength mass had been evaluated using handgrip dual-energy X-ray absorptiometry, respectively. was defined according to criteria...
Our aim was to investigate the significance of neck circumference (NC) on presence and severity obstructive sleep apnea (OSA) syndrome independent visceral fat (VF) obesity. A total 219 subjects with suspected OSA underwent a complete polysomnography (PSG) study, along measurement NC, body (TF) VF levels (VFLs) measured by bioelectrical impedance analysis. We proposed NC divided height (NC/H) as simple index for height-corrected in Japanese subjects. NC/H exhibited significantly stronger...
Sclerostin, which is secreted exclusively by osteocytes, a negative regulator of bone formation. The role sclerostin in chronic kidney disease-mineral and disorder not well known. In the present study, we examined relationship between serum levels, turnover markers, mineral density (BMD) radius maintenance hemodialysis patients. This was cross-sectional study that analyzed sclerostin, alkaline phosphatase (a formation marker), tartrate-resistant acid 5b resorption marker) stored samples from...
We recently reported that glycated albumin (GA) is a better indicator of glycaemic control compared with haemoglobin (HbA1c) in haemodialysis (HD) patients type 2 diabetes. As poor considered an independent risk factor for atherosclerosis diabetes, the relationship between GA, HbA1c and arterial stiffening was examined HD diabetes.The present study comprised 134 158 without Brachial-ankle pulse wave velocity (baPWV) measured all using waveform analyser.The mean plasma glucose (PG), GA levels...
Background and objectives Vitamin D receptor activators calcimimetics (calcium-sensing agonists) are two major options for medical treatment of secondary hyperparathyroidism. A higher serum calcification propensity (a shorter T 50 value) is a novel surrogate marker stress mortality in patients with CKD. We tested hypothesis that calcimimetic agent etelcalcetide more effective increasing value than vitamin activator maxacalcitol. Design, setting, participants, & measurements randomized,...
The potency of darbepoetin-α (DPO-α) to improve anemia in hemodialysis (HD) patients is greater than that recombinant human erythropoietin (rHuEPO).To assess the DPO-α mobilize iron from body stores comparison with rHuEPO HD without apparent inflammation or infection, serum iron, transferrin saturation (TSAT), ferritin, and hepcidin-25 were measured serially. This study included (i) a long-term crossover for 3 yr compare effects two erythropoiesis-stimulating agents (ESA) on TSAT, (ii)...
Bone-specific alkaline phosphatase (BAP) hydrolyzes pyrophosphate, which inhibits vascular calcification. We examined association between serum BAP and calcification of male hemodialysis patients.Hand roentgenography 167 maintenance patients was conducted, visible the hand arteries evaluated. Serum levels 3 bone formation markers (BAP, osteocalcin, N-terminal propeptide type I collagen) 2 resorption (C-terminal telopeptide collagen, cross-linked N-telopeptide were measured, along with intact...
OBJECTIVE—ACE inhibitors are known to be effective in preventing the progression of diabetic nephropathy. Activation renin-angiotensin system (RAS) is reported contribute intrarenal hemodynamic abnormality patients. We examined whether RAS blockade by captopril induces changes normotensive patients with type 2 diabetes. RESEARCH DESIGN AND METHODS—The ranged age from 40 65 years (20 men and 20 women). A total 15 age- sex-matched healthy individuals served as control subjects. Resistive index...
Little is known about the relationship between fat mass distribution and chronic inflammation in dialysis patients, whom related to morbidity mortality.The lean masses (truncal nontruncal) of 452 hemodialysis patients (age: 64 ± 11 years; duration: 89 77 months; 37% diabetics) were measured by dual X-ray absorptiometry their association with high-sensitivity C-reactive protein (hsCRP) was examined.The high hsCRP group (n = 106) significantly higher than that normal 346; p < 0.05); there no...
It has been reported that there is a significant positive relationship between PTH and body weight or mass index in the general population. However, little known about this dialysis patients whom levels are higher. also not whether fat lean associated with serum among these patients. In present study, we examined association of intact hemodialysis patients.Serum PTH, calcium, phosphate were measured 590 (age, 60.2 ± 12.2 y; median duration, 59.6 mo; 343 males 247 females; diabetics, 27.7%)....
Abstract The negative relation of serum adiponectin to atherosclerosis becomes a positive association in patients with chronic kidney disease (CKD). We conducted small-scale cross-sectional observational study, 101 Japanese male hemodialysis patients, examine the relationship and leptin abdominal aortic calcification (AAC). presence AAC was evaluated from simple X-ray radiographs left lateral abdomen. Serum significantly higher AAC-positive [18.8 (13.0–28.1) μg/mL] than AAC-negative [15.4...
Cinacalcet, an allosteric modulator of the calcium sensing receptor, effectively reduces serum parathyroid hormone (PTH) in patients with secondary hyperparathyroidism. It is not well known whether bone mineral density (BMD) hemodialysis hyperparathyroidism altered after cinacalcet treatment.The BMD distal 1/3 radius and ultradistal radius, which are enriched cortical cancellous bone, respectively, was examined by dual X-ray absorptiometry, 1 year prior to, at start, treatment, 61...
Serum magnesium (Mg) levels have been associated with muscle performance in the general population. We hypothesized that serum Mg would be quality hemodialysis patients. A total of 310 patients were examined (age: 58 ± 12 years, duration: 6.4 6.0 60.6% men, and 36.1% diabetics). Arm lean mass was measured by dual energy X-ray absorptiometry (DXA) on dominant side. defined as ratio handgrip strength to arm same side (kg/kg). 1.15 0.16 mmol/L (2.8 0.4 mg/dL), being higher than reference range...