Abstract When LPS is administered to heat-killed Propionibacterium acnes-primed BALB/c nude mice, they develop endotoxin-induced liver injury. As previously reported, this injury can be prevented by treatment with an Ab against IL-18, a novel cytokine the ability induce IFN-gamma production and up-regulate functional Fas ligand (FasL) expression. To identify pathologic role of IL-18 in injury, we investigated hepatic network FasL induction after challenge. After challenge their livers...

Dapagliflozin is a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor under development as treatment for type diabetes mellitus (T2DM). This study assessed the efficacy and safety of dapagliflozin monotherapy in Japanese T2DM patients with inadequate glycaemic control.Patients (n = 279) were randomized to receive (1, 2.5, 5 or 10 mg/day) placebo once daily 12 weeks. The primary endpoint was change from baseline haemoglobin A1c (HbA1c) at week 12. Secondary endpoints included fasting...

Studies in Finland, England, and Denmark have reported that individuals exposed to the 1957 A2 influenza pandemic during their second trimester utero are at greater risk for later schizophrenia. However, other studies United States, Holland no such association. The authors' goal was shed light on these conflicts.They compared number of who developed schizophrenia were born 5 months after peak prevalence three distinct epidemics Japan with mean corresponding 4 years surrounding epidemics.A...

Abstract The objective of the present study was to examine efficacy group musical therapy for inpatients with DSM‐IV schizophrenia or schizoaffective psychosis. Thirty‐four subjects in a ward long‐stay female patients received 15 sessions over 4 months, while 32 waiting from another same function were wait until studied course completed. assessment included measures psychotic symptoms, quality life and subjective experiences. Comparison groups indicated that significant advantages detected...

The purpose of the present study is to test interrater reliability Japanese version Positive and Negative Syndrome Scale (PANSS) examine factors possibly affecting reliability. group conducted PANSS rating on 20 patients with DSM‐IV schizophrenia. For analysis reliability, intraclass correlation coefficient (ICC) was calculated. ICC for individual items ranged from 0.26 0.92, those positive, negative, general psychopathology subscales were 0.85, 0.83 0.75, respectively. Cronbach's alpha...

Patients admitted to a psychiatric hospital with suicidal behavior (SB) are considered be especially at high risk of suicide. However, the number studies that have addressed this patient population remains insufficient compared on patients in emergency or medical settings. The purpose study is seek features sample newly metropolitan area Japan. 155 consecutively large center during 20-month period, admission styles whom were mostly involuntary, assessed using Structured Clinical Interviews...

Abstract Synaptotagmin XI ( Syt11 ) is a member of the synaptotagmin family, which localized in cells either synaptic vesicles or cellular membrane, and known to act as calcium sensor. The gene located on chromosome locus 1q21‐q22, was previously reported major susceptibility familial schizophrenia. Here, we present evidence for an association between number 33‐bp repeats promoter region We found that transcriptional activity affected by repeats, include Sp1 binding site, suggesting...

It is acknowledged that a considerable proportion of patients who have an episode acute and transient psychotic disorder (ATPD), will develop schizophrenia after the remitted. If features discriminating later developed from those underwent monomorphous ATPD-only course are discerned, they may be useful for predicting prognosis. The authors performed chart review study were hospitalized with diagnosis ATPD followed up thereafter >5 years compared two subject groups: 10...

Abstract Use of coping techniques is importance in the treatment for patients experiencing auditory hallucinations. Phenomenological features hallucinations and other psychotic symptoms are assumed to be factors influencing activities. The aim present study was determine including hallucination phenomenological that have effects on authors investigated 17 generally used 144 chronically who were currently DSM‐IV schizophrenia or schizoaffective psychosis. Using factor analysis, scales...

Suicidal patients admitted to a psychiatric hospital are considered be at risk of suicidal behavior (SB) and suicide. The present study aimed seek predictors SB recurrence the high-risk by examining their post-hospitalization course.The design was 2-year prospective follow-up consecutively with center in Tokyo. DSM-IV diagnoses SB-related features subjects were determined structured interviews. Subsequently, underwent series assessments 6-month intervals. assessment included inquiries into...

By means of the multisample structured strategy, we examined gender differences in a five-factorial structure model Positive and Negative Syndrome Scale (PANSS) ratings 308 patients both sexes with DSM-IV schizophrenia comparable age at investigation overall symptomatic severity across sex. The test indicated that factors component symptoms were common sex, whereas factor loadings might be different. However, incorporated difference did not improve fit indices. Therefore, it is concluded...

Abstract The purpose of the present study was to examine role occupation and social experience as factors determining attitude psychiatric care workers other from various backgrounds toward people with schizophrenia. To measure 786 subjects six occupational groups schizophrenia, evaluation scale applying semantic differential technique modified Social Rejection Scale were used, which assess two aspects attitude: affective acceptance distancing, respectively. results scales similar on whole....

Abstract Auditory hallucinations include particularly diverse phenomena that reflect various mental functions and pathologies. Their assessment may provide valuable clinical information. This article describes the development of Matsuzawa Assessment Schedule for Hallucination (MASAH), which was designed to obtain a broadened view by investigating wide range their characteristics. The aim identify basic phenomenological features auditory performing factor analytic study MASAH ratings 214...

Background Suicidal behavior (SB) is a major, worldwide health concern. To date there limited understanding of the associated motivational aspects which accompany this self-initiated conduct. Aims develop method for identifying features with SB by studying admitted psychiatric patients, and to examine their clinical relevance. Methods By performing factor analytic study using data obtained from patient sample exhibiting high suicidality variety methods, Motivations Scale (MSBS) was...

Objective To investigate the utility of voxel-based specific regional analysis system for Alzheimer’s disease (VSRAD). Methods Clinical data from patients who underwent screening dementia using VSRAD and Japanese version COGNISTAT, Neurobehavioral Cognitive Status Examination, were retrospectively investigated to specify domains cognitive function that correlate with statistical mean value positive Z-scores in target volume-of-interest (VOI). A receiver operating characteristic (ROC) curve...

Suicidal behavior (SB) is a major mental health problem. The research has identified many factors related to SB, such as problems in the developmental period and psychiatric personality disorders. However, interrelation of these not been clearly delineated.The subjects were 155 patients consecutively admitted with SB center Tokyo. Structured interviews, including Clinical Interview for DSM-IV (SCID)-I SCID-II, conducted determine characteristics SB-related factors. To illustrate their...

Abstract An excess of schizophrenic births in winter or early spring is a well replicated finding studies on Western populations. However, there are few Asian populations, and their results not consistent. We examined the seasonality Japanese subjects ( n = 1024) born between 1955 1960. Our showed significant inverse relationship temperature number births, which line with findings In our data, observed reduction summer was more marked than winter. suggest possibility that birth may have some...