A5089880519- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Disease Prevention
- Chronic Kidney Disease and Diabetes
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trace Elements in Health
- Cerebrovascular and Carotid Artery Diseases
- Diabetes and associated disorders
- Magnesium in Health and Disease
- Renal Diseases and Glomerulopathies
- Acute Ischemic Stroke Management
- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Renal function and acid-base balance
- Macrophage Migration Inhibitory Factor
- Gout, Hyperuricemia, Uric Acid
- Heavy Metal Exposure and Toxicity
- Diabetes Treatment and Management
- COVID-19 Clinical Research Studies
- Folate and B Vitamins Research
Osaka Metropolitan University
2023-2024
Osaka City University
2011-2022
Osaka City University Hospital
2022
Yale University
2017-2019
Arkana Laboratories
2018-2019
Menzies Institute for Medical Research
2017-2019
Association for Research and Industrial Development of Natural Resources
2015
Osaka Hospital
2009
Clinical data after cardiac surgery and experimental mouse models of acute kidney injury suggest a renoprotective role macrophage migration inhibitory factor (MIF).
During the ongoing coronavirus disease 2019 (COVID-19) pandemic, it is critical to ensure safety of COVID-19 vaccines. We herein report a 51-year-old Japanese woman who developed acute-onset type 1 diabetes with diabetic ketoacidosis six weeks after receiving first dose messenger ribonucleic acid (mRNA) vaccine. Laboratory tests indicated exhaustion endogenous insulin secretion, positive result for autoantibody, and latent thyroid autoimmunity. Human leukocyte antigen typing was homozygous...
Fulminant type 1 diabetes is characterized by a rapid progression of insulin deficiency triggered viral infection. Here, we report case 45-year-old Japanese woman with fulminant that developed 8 days after receiving messenger ribonucleic acid vaccine against severe acute respiratory syndrome coronavirus 2. She had been healthy and no symptoms suggestive infection before the vaccination. Laboratory tests showed exhaustion secretion negative results for islet autoantibodies. Human leukocyte...
ABSTRACT Background Fetuin-A inhibits precipitation of calcium-phosphate crystals by forming calciprotein particles (CPP). A novel T50 test, which measures transformation time from primary to secondary CPP, is an index for calcification propensity. Both lower fetuin-A and shorter levels were associated with cardiovascular disease (CVD) risk in patients chronic kidney (CKD). Extremely high CVD death advanced CKD consists high-incidental event mortality after event. To date, it unclear whether...
Macrophage migration inhibitory factor (MIF) is a cytokine with pleiotropic actions that produced by several organs and cell types. Depending on the target inflammatory context, MIF can engage its two component receptor complex CD74 CD44 chemokine receptors CXCR2/4. constitutively expressed in renal proximal tubular cells, stored intracellular preformed pools, released at low rate. Recently, second MIF-like protein (i.e., MIF-2/D-DT) has been characterized mammals. Our study was aimed...
Hyperuricemia has been reported to affect renal hemodynamics in rat models. We evaluate the relationship between serum uric acid and intrarenal hemodynamic parameters humans, utilizing plasma clearance of para-aminohippurate (CPAH ) inulin (Cin).Renal glomerular were assessed by simultaneous measurement CPAH Cin 58 subjects. Of these, 19 subjects planned provide a kidney for transplantation; 26 had diabetes without proteinuria; 13 mild proteinuria. Renal calculated using Gomez`s formulae.Cin...
Low thyroid function may be associated with a reduced glomerular filtration rate (GFR) calculated on the basis of creatinine metabolism. Thyroid hormone directly affects serum in muscle and low might exert similar direct effect kidney. The goal study was to evaluate this possibility by assessment inulin-based GFR examine mechanism underlying reduction GFR.Renal hemodynamics were assessed simultaneous measurements plasma clearance para-aminohippurate (CPAH) inulin (Cin) 26 patients <1.00...
Fetuin-A, a circulating glycoprotein synthesized in the liver, is involved insulin resistance and type 2 diabetes. However, regulation of fetuin-A synthesis has remained obscure. We previously reported that pioglitazone treatment significantly reduced serum levels patients with To clarify whether can directory inhibit hepatic synthesis, we investigated effects on expression both vitro vivo. Pioglitazone suppressed mRNA protein Fao hepatoma cells. Interestingly, rosiglitazone but not...
OBJECTIVE Little is known about the relationships between insulin resistance, intrarenal hemodynamics, and urinary albumin excretion (UAE) in humans with impaired fasting glucose (IFG) and/or tolerance (IGT). The aim of current study was to examine hemodynamic abnormalities, UAE subjects IFG or IGT. We hypothesized that abnormalities would be associated resistance. RESEARCH DESIGN AND METHODS Fifty-four kidney donors underwent 75-g oral inulin para-aminohippuric acid clearance testing....
Acute kidney injury (AKI) is one of the most frequent complications after cardiac surgery and associated with poor outcomes. Biomarkers AKI are crucial for early diagnosis this condition. Secretory leukocyte protease inhibitor (SLPI) an alarm anti-protease that has been implicated in pathogenesis but not yet studied as a diagnostic biomarker AKI. Using two independent cohorts (development cohort (DC), n = 60; validation (VC), 148), we investigated performance SLPI marker surgery. Serum...
<b><i>Background/Aim: </i></b>The aim of the present study was to quantitatively examine factors associated with aortic calcification in non-dialysis CKD patients. <b><i>Methods: </i></b>We investigated from renal artery bifurcation 149 patients (58±16 years; 96 males and 53 females, 48 diabetics; eGFR 40.3±29.3 ml/min), measured Agatston scores using multi-slice computed tomography. <b><i>Result: </i></b>Of patients,...
ObjectiveInfection is related to a higher rate of hospitalization and subsequent death in patients undergoing hemodialysis. Limited data are available about factors associated with after for infection. Nutritional disorder also known as protein energy wasting profoundly poor consequences. The Geriatric Risk Index (GNRI) simple but useful nutritional screening tool predict mortality. We examined whether the GNRI could infection death.Design MethodsThis was prospective cohort study on...
Fetuin-A is a liver-derived circulating protein that has potent calcification-inhibitory activity. Uraemic patients exhibit decreased serum fetuin-A levels, increased vascular calcification and elevated cardiovascular mortality. Because the mechanisms for deficiency are unknown, we hypothesized some uraemic toxins suppressed hepatic production, which resulted in accelerated poor outcome. Among these potential candidates, indoxyl sulfate (IS) highly toxic properties. We examined direct...
Aim: Inter-arm blood pressure difference (IAD) is known to be associated with a composite of cardiovascular disease (CVD) and CVD risk factors. However, only limited information available regarding the contribution diabetes mellitus IAD association individual CVDs, such as coronary artery (CAD), stroke, peripheral (PAD).
Abstract Elemental concentrations in hair from hemodialysis (HD) patients have not been well investigated. We examined the relationships between elemental scalp and health‐related quality of life (HRQOL) nutritional status HD patients. Twenty six were measured samples 60 male using inductively‐coupled plasma mass spectrometry. To evaluate HRQOL, Short Form 36 item health survey (SF36) was used. As indices status, body index, serum parameters, geriatric risk index (GNRI) Phosphorus correlated...
Background: Extracellular magnesium (Mg) accounts for approximately 1% of the total body Mg. Clinically, serum Mg concentration is measured, but it does not necessarily reflect status. Although relationships have been reported between reduced and cardiovascular disease in non-dialysis patients, there few such studies hemodialysis patients. It was hypothesized that Mg, as represented by lower hair, would be associated with echocardiographic parameters chronic Methods Results: Hair measured 79...
β2-Microglobulin (β2-MG) is a major protein component of dialysis-related amyloidosis. In long-term hemodialysis (HD) patients, β2-MG amyloid deposits not only in osteoarticular tissues, but also systemic including the heart. The purpose this study was to investigate relationship between serum concentrations and echocardiographic parameters HD patients cross-sectional study.Measurement echocardiography were performed 251 who had undergone therapy for more than 10 years.The left ventricular...
Low T3 syndrome is characterized by low serum triiodothyronine (T3) levels without elevation of thyroid-stimulating hormone (TSH) in patients apparent thyroid disease, which known to be associated with worse clinical outcomes various populations including those kidney failure. In this study, we examined whether free (FT3) are independent predictor cardiovascular disease (CVD) events undergoing hemodialysis.This was a prospective cohort study chronic hemodialysis. From the total 518 patients,...
Abstract Fetuin-A is an inhibitor of ectopic calcification that expressed mainly in hepatocytes and secreted into the circulation after posttranslational processing, including glycosylation phosphorylation. The molecular weight (MW) fully modified fetuin-A (FM-fetuin-A) approximately 60 kDa immunoblot, which much higher than estimated MW by amino acid sequence. Under conditions stress such as advanced stage chronic kidney disease, prevents forming colloidal complexes, are referred to...
Increased level of serum fibroblast growth factor 23 (FGF23) is a hallmark abnormal phosphate metabolism in patients with chronic kidney disease (CKD) and recently shown to be associated the risk cardiovascular even those without CKD. This study investigated association between FGF23 levels vascular function type 2 diabetes.This was cross-sectional involving 283 Japanese diabetes. Flow-mediated dilatation (FMD) nitroglycerin-mediated (NMD) brachial artery were measured via ultrasonography...
Stiffness parameter β (stiffness β), a clinical estimate of arterial stiffness, increases with the progression systemic atherosclerosis. Atherosclerosis is frequently and severely observed in patients diabetic kidney disease (DKD) which defined by decreased estimated glomerular filtration rate (eGFR) and/or elevated urinary albumin creatinine ratio (UACR). Both eGFR UACR are known as risk factors However, contribution each factor, or UACR, to stiffness remains unclear. The present study...