A5080925131- Renal Diseases and Glomerulopathies
- Trauma and Emergency Care Studies
- Autoimmune Bullous Skin Diseases
- Pharmaceutical Practices and Patient Outcomes
- Chronic Kidney Disease and Diabetes
- Patient Safety and Medication Errors
- Emergency and Acute Care Studies
- Cardiac Arrest and Resuscitation
- Pharmaceutical studies and practices
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory viral infections research
- Sepsis Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Pneumonia and Respiratory Infections
- Platelet Disorders and Treatments
- Acute Ischemic Stroke Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Acute Kidney Injury Research
- Hemodynamic Monitoring and Therapy
- Systemic Lupus Erythematosus Research
- Respiratory Support and Mechanisms
- Electronic Health Records Systems
- Pharmacovigilance and Adverse Drug Reactions
- Intraperitoneal and Appendiceal Malignancies
- Antimicrobial Resistance in Staphylococcus
RWTH Aachen University
2012-2023
Universitätsklinikum Aachen
2011-2020
Statistics Austria
2015
The outcomes of immunosuppressive therapy, when added to supportive care, in patients with IgA nephropathy are uncertain.We conducted a multicenter, open-label, randomized, controlled trial two-group, parallel, group-sequential design. During 6-month run-in phase, care (in particular, blockade the renin-angiotensin system) was adjusted on basis proteinuria. Patients who had persistent proteinuria urinary protein excretion at least 0.75 g per day were randomly assigned receive alone...
Background Inter-hospital teleconsultation improves stroke care. To transfer this concept into the emergency medical service (EMS), feasibility and effects of prehospital were investigated. Methodology/Principal Findings Teleconsultation enabling audio communication, real-time video streaming, vital data still picture transmission was conducted between an ambulance a center. Pre-notification hospital carried out with 14-item history checklist via e-mail-to-fax. Beside technical assessments...
The role of immunosuppression in IgA nephropathy (IgAN) is controversial. In the Supportive Versus Immunosuppressive Therapy for Treatment Progressive Nephropathy (STOP-IgAN) Trial, 162 patients with IgAN and proteinuria >0.75 g/d after 6 months optimized supportive care were randomized into two groups: continued or additional (GFR≥60 ml/min per 1.73 m 2 : 6-month corticosteroid monotherapy; GFR=30–59 cyclophosphamide 3 followed by azathioprine plus oral prednisolone). Coprimary end...
In emergency medicine, the benefits of high-fidelity simulation (SIM) are widely accepted and standardized patients (SP) known to mimic real accurately. However, only limited data available concerning physicians' stress markers within these training environments. The aim this pilot study was investigate repetitive among healthcare professionals in simulated pre-hospital scenarios using either SIM or SPs. Teams with one medical services (EMS) physician two paramedics completed three SP...
In this study we calculate the effectiveness of pneumococcal conjugate vaccines (PCV) against invasive disease (IPD) among children under age two years using indirect cohort method. We also discuss timeliness vaccination and residual cases vaccine type IPD.From July 2006 until June 2015, 921 IPD were reported for 618 (67.1%), status at time infection could be accurately determined. Of these, 379 (61.3%) vaccinated 239 (38.7%) not vaccinated. The adjusted (VE) PCV7 all included serotypes + 6A...
A nationwide laboratory-based surveillance study of invasive S. pyogenes infections was conducted in Germany. Invasive isolates (n = 719) were obtained between 2009 and 2014. Most from blood (92.1%). The proportions cerebrospinal fluid, pleural synovial fluid peritoneal 3.9%, 1.8%, 1.7% 0.6%, respectively. most common emm types 1 (31.8%), 28 (15.4%) 89 (14.5%). superantigen genes (speA, speC, speG, speH, speI, speJ, speK, speL, speM, ssa) identified speG (92.1%), speJ (50.9%), speC (42.0%)....
Prehospital hypertensive emergencies and urgencies are common, but evidence is lacking. Telemedically supported were prospectively collected (April 2014–March 2015) compared retrospectively with a historical control group of on‐scene physician care in the emergency medical service Aachen, Germany. Blood pressure management guideline adherence evaluated. Telemedical (n=159) vs conventional (n=172) cases: blood reductions 35±24 mm Hg 44±23 revealed effect adjusted for baseline differences ( P...
The Oxford classification of IgA nephropathy (IgAN) defines histologic criteria (MEST-C) that provide prognostic information based on the kidney biopsy. There are few data predictive impact this in randomized clinical trial settings. We performed an exploratory analysis MEST-C scores 70 available renal biopsies from 162 STOP-IgAN participants and correlated results with outcomes. Analyses were by researchers blinded to outcome patients. Biopsies had been obtained 6.5 95 (median 9.4) months...
Sepsis is a major health care problem with high morbidity and mortality rates affects millions of patients. Telemedicine, defined as the exchange medical information via electronic communication, improves outcome patients sepsis decreases rate length stay in intensive unit (ICU). Additional telemedicine rounds could be an effective component performance-improvement programs for sepsis, especially underserved rural areas hospitals without ready access to critical physicians.Our aim was...
Acute kidney injury (AKI) is one of the most frequent complications after cardiac surgery and associated with poor outcomes. Biomarkers AKI are crucial for early diagnosis this condition. Secretory leukocyte protease inhibitor (SLPI) an alarm anti-protease that has been implicated in pathogenesis but not yet studied as a diagnostic biomarker AKI. Using two independent cohorts (development cohort (DC), n = 60; validation (VC), 148), we investigated performance SLPI marker surgery. Serum...
Abstract Background: Medical emergencies in dental practice are generally perceived as being rare. Nonetheless, recent studies have shown that incidents occur on a regular basis. Therefore, patients the right to expect necessary skills manage life‐threatening situations from every dentist. Objective: To observe students’ attitude and self‐assessment towards emergency medical care (EMC) its practical appliance. Material methods: Students of dentistry took part small group sessions for adult...
A tele-emergency medical service with a remote emergency physician for severe prehospital emergencies may overcome the increasing number of calls and shortage providers. We analysed whether routine use is non-inferior to conventional physician-based one in occurrence intervention-related adverse events.This open-label, randomised, controlled, parallel-group, non-inferiority trial included all patients aged ≥ 18 years within ground-based ambulance Aachen, Germany. Patients were randomised 1:1...
Background & aimsRecent studies indicate that vitamin D deficiency is associated with increased morbidity and mortality in critically ill patients. Knowledge about the functional role clinical relevance of for patients undergoing cardiac surgery sparse. Therefore, we investigated significance levels on outcome patients.Methods92 elective cardiopulmonary arrest were included this prospective observational pilot study. 25-hydroxyvitamin (25OHD) 1,25-dihydroxyvitamin (1,25(OH)2D) measured prior...
Elderly patients are vulnerable to adverse drug reactions (ADRs). Drug-related readmissions (DRRs) can be a major consequence of ADR. Therefore, this study aimed investigate the effects ward-based, comprehensive pharmaceutical care service on occurrence DRRs as endpoint in dependent-living elderly patients.A randomized, controlled trial was performed at German University Hospital. Patients fulfilling following criteria were eligible: admission cooperating ward, existing therapy admission, 65...
Purpose: To determine the type, frequency, and factors associated with medication preparation administration errors in adult intensive care units (ICUs) neonatal ICUs (NICUs)/pediatric (PICUs). Patients methods: We conducted a prospective direct observation study an ICU NICU/PICU tertiary university hospital. Between June 2012 2013, clinical pharmacist medical student observed nursing staff on weekdays during of intravenous drugs. analyzed frequency type errors. Results: Six hundred three...
Oxidative stress contributes to organ dysfunction after cardiac surgery and still represents a major problem. Antioxidants, such as vitamins C E might be protective.The primary objective of this prospective observational study was the description evaluate perioperative vitamin levels in 56 patients undergoing with use cardiopulmonary bypass. The association inflammatory reaction, oxidative stress, dysfunctions, clinical outcomes were evaluated an explorative approach.Vitamin decreased...
Abstract Background Inhibitors of the renin-angiotensin system (RAS) are cornerstones supportive therapy in patients with IgA nephropathy (IgAN). We analyzed effects single versus dual RAS blockaQueryde during our randomized STOP-IgAN trial. Methods participants available successive information on their treatment regimen and renal outcomes 3-year trial phase were stratified post hoc into two groups, i.e. under continuous or blocker over entire 3 years phase. Primary secondary endpoints,...
Still picture transmission was performed using a telemedicine system in an Emergency Medical Service (EMS) during prospective, controlled trial. In this ancillary, retrospective study the quality and content of transmitted pictures possible influences application on prehospital time requirements were investigated. A digital camera used with enabling encrypted audio data between ambulance remotely located physician. By default, images compressed (jpeg, 640 x 480 pixels). On occasion,...