A5101885813- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Renal cell carcinoma treatment
- Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Gallbladder and Bile Duct Disorders
- Clusterin in disease pathology
- Liver Disease Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Gastrointestinal Tumor Research and Treatment
- Cancer-related gene regulation
- Multiple and Secondary Primary Cancers
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Treatments and Studies
- Bone health and osteoporosis research
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic factors in colorectal cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Research and Treatments
Chiba University
2015-2025
Japan Food Research Laboratories
2021
Tenshi Hospital
2018
National Institute of Biomedical Innovation, Health and Nutrition
2014-2017
Osaka City University
2012-2014
Seirei Hamamatsu General Hospital
2013
Osaka Medical Center for Cancer and Cardiovascular Diseases
1975-1983
In order to elucidate the natural history of early gastric cancer, we followed up non-concurrently certain patients who had been diagnosed endoscopically as having "early' cancer and histological evidence by biopsy, but on whom surgical resection delayed or not conducted. At Center for Adult Diseases, Osaka, 56 cases were eligible this study. Out these, 27 progressed advanced 16 remained at stage during follow-up period (6-88 months, mean: 29 months). The remaining 13 neither nor...
Leucine-rich alpha 2 glycoprotein (LRG) has been identified as a serum protein elevated in patients with active rheumatoid arthritis (RA). Although the function of LRG is ill-defined, binds transforming growth factor (TGF)-β and enhances Smad2 phosphorylation. Considering that imbalance between T helper 17 (Th17) cells regulatory (Treg) plays important roles pathogenesis RA, may affect arthritic pathology by enhancing TGF-β-Smad2 pathway pivotal for both Treg Th17 differentiation. The...
TGF-β has an important role in fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). Detailed analysis of signaling at the molecular level is needed to identify novel therapeutic targets. Recently, leucine-rich alpha-2 glycoprotein (LRG) was reported function as a modulator angiogenesis and tumor progression. However, involvement LRG disorders, IPF, not yet been investigated. In this study, we investigated by analyzing knockout (KO) mice with bleomycin-induced lung fibrosis,...
Krüppel-like factor 5 (KLF5) plays an oncogenic role and has diverse functions in cancer cells. However, correlation between KLF5 clinical outcome not been determined patients with colorectal liver metastasis. Herein, we analyzed 65 who developed Clinical effects were assessed through immunohistochemical analysis of primary lesions metastatic lesions. High expression these tissues correlated the presence vascular invasion, elevated serum carbohydrate antigen 19-9 levels, large diameters...
Percutaneous endoscopic gastrostomy (PEG) is commonly performed for enteral nutrition in patients with various diseases. However, there are few reports on abdominal surgeries after PEG, and the tips these procedures have not been established. Specifically, laparoscopic of upper abdomen, a can interfere surgical field. In addition, perioperative management concomitant diseases that require PEG placement, including neuromuscular disorders, required. A 64-year-old man due to malnutrition from...
Intrahepatic cholangiocarcinoma (ICC) is resistant to most chemotherapeutic agents. Yes-associated protein (YAP) related tumor progression; however, its role in ICC remains unknown. We investigated the mechanism underlying YAP-mediated cancer progression by focusing on property of stem cells (CSCs) ICC. Immunohistochemistry results revealed positive YAP expression 37 52 resected cases. Those with showed poor prognosis Kaplan-Meier analysis (P = 0.023). was associated vimentin and putative...
Fibroblast growth factor (FGF)-23, secreted from osteocytes/osteoblasts, plays major roles in phosphate (Pi)-mediated stimulation of PTH secretion and consequently regulation serum Pi. Osteocyte/osteoblast dysfunction develops patients with type 2 diabetes mellitus (DM).Our objective was to examine whether increases FGF-23 after oral Pi are impaired DM.The subjects were 10 DM non-DM without chronic kidney disease stage 3-5. Serum FGF-23, intact (iPTH), measured serially administration at a...
The exact contribution of preoperative coil embolization in distal pancreatectomy with en bloc celiac axis resection (DP-CAR) for the prevention ischemic liver complication is not fully elucidated.From January 2004 to July 2015, 31 patients underwent DP-CAR pancreatic body-tail cancer. Twenty-three received embolization. characteristics and operative outcomes were analyzed retrospectively.The median survival time 1- 3-year overall rates 23.7 months 74.2% 34.4%, respectively. No 30-day...
Cortical porosity is increasingly recognized as an important risk for fracture in DM patients. The present study demonstrated that decreased cortical thickness, assessed using a newly developed quantitative ultrasonic bone densitometry, significant factor vertebral fractures type 2 diabetes mellitus patients with stage 3 or higher chronic kidney disease, but not those without. (T2DM) well disease (CKD) whom serum parathyroid hormone (PTH) starts to increase. aimed clarify whether the...
Abstract Background/Purpose The objective of this study was to determine the frequency and predictors biliary tract cancer (BTC) with deficient DNA mismatch repair (dMMR) in Japan. Methods Immunostaining microsatellite instability analysis were performed for repair‐related proteins tissue specimens from 662 patients who underwent surgery BTC between 2001 2017 identify dMMR‐BTC. We compared dMMR‐BTC proficient MMR (pMMR)‐BTC based on patient demographics, pathological features, host immune...
Although some clinical trials have demonstrated the benefits of neoadjuvant therapy for resectable pancreatic ductal adenocarcinoma (PDAC), its optimal candidate has not been clarified. This study aimed to detect predictive prognostic factors PDAC patients who underwent upfront surgery and identify patient cohorts with long-term survival without therapy.
Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of unknown etiology that affects the intra- and extrahepatic bile ducts. The present study examined utility proteome analysis using high-sensitivity mass spectrometer to comprehensively screen for novel PSC biomarkers.Bile endoscopically collected from patients with PSC, common duct stones, biliary tract cancer were subjected high-precision liquid chromatography/mass spectrometry. Some proteins specifically up-regulated...
Invasive pancreatic neoplasms have a high propensity for recurrence even after curative resection. Recently, patients who underwent pancreatectomy an opportunity of undergoing secondary resection, so-called "repeat pancreatectomy" to achieve operation and prolong their survival. We evaluated the long-term clinical outcomes identified prognostic factors, including systemic inflammation markers lymphocyte-to-monocyte ratio (LMR) repeat invasive tumors.Twenty-eight consecutive with (22 ductal...
Abstract Background and Aim Postoperative hemorrhage is a rare but potentially lethal complication of hepatobiliary pancreatic surgeries. This study aimed to retrospectively evaluate the clinical outcome patients with delayed postoperative compare results according surgical procedure. Methods Overall, 4220 underwent surgery for diseases. Delayed (observed more than 24 h postoperatively) occurred in 62 patients. Of these, 61 interventional radiology achieve hemostasis. Patients' data were...
ABSTRACT Caudal autotomy in rodents is an evolutionarily acquired phenomenon enabling escape from predators, by discarding the tail skin after traumatic injuries. The histological mechanisms underlying caudal seem to differ among species. Cotton rats (Sigmodon hispidus), which are important laboratory for human infectious diseases, possess a fragile tail. In this study, we compared histology of cotton with that (Rattus norvegicus), have no fragility on their tail, elucidate process rodent...
527 Background: Pancreaticobiliary maljunction (PBM) is a congenital malformation in which the pancreatic duct and bile anatomically merge outside duodenal wall, associated with high rate of biliary cancer. It has been reported that TP53 KRAS mutations are found not only cancerous area but also noncancerous area. However, there no report precise mapping genetic throughout gallbladder ducts. Methods: Ninety-seven patients (including 31 cancer) who underwent cholecystectomy cholangiectomy for...
Intrahepatic cholangiocarcinoma (ICC) is known to have a high frequency of lymph node metastasis. Lymph dissection (LND) recommended for accurate staging, but the survival benefit LND remains unclear. Knowledge pathways and direction lymphatic drainage regional nodes essential when considering improve patient survival. The liver has three pathways: portal, sublobular, subcapsular. Of these, portal pathway, which lies along with tracts, primary pathway. efferent vessels from left-sided liver,...