Disinfection is crucial for preventing surgical site infections. Recently, the effectiveness of sanitizers using chlorous acid (HClO2) under conditions rich in organic matter has been reported, and water (CAW) approved as a food additive. This study evaluated potential CAW new presurgical disinfectant cattle. The experiments were performed on paralumbar fossa cattle Sapporo during March (winter to spring) August (summer). Colony-forming units (CFUs) standard plate count bacteria (SPCB),...

Background Interstitial collagen accumulation has been extensively demonstrated to be increased at both mRNA and protein levels in pressure-overloaded cardiac hypertrophy. However, few data are available regarding the effects of volume overload on myocardial collagens. Methods Results To determine whether alterations collagens may occur volume-overloaded hypertrophy, we measured types I III left ventricular (LV) myocardium rats 3, 7, 28 days after creation an aortocaval (AC) shunt. Eccentric...

Significance Statement Tertiary lymphoid structures (TLSs) form in organs exhibiting chronic inflammation. Immune responses to infections, autoimmune responses, or allergic may trigger TLS development. We observed urine–urothelium barrier alterations the renal pelvis of a mouse model and human subjects with nephritis, without infection. Furthermore, urine leaked from lumen into parenchyma nephritic mice. This stimulated production cytokines/chemokines stromal cells, resulting development...

Lupus nephritis (LN) is a common complication in young patients and the most predominant cause of glomerulonephritis. Infiltrating immune cells presence immunocomplexes kidney are hallmarks LN, which closely associated with renal lesions (RLs). However, their regulatory mechanism remains unclear, valuable for prevention RL development. Here, we show development vasculature-associated lymphoid tissue (VALT) related to inflammatory cytokines, indicating that VALT unique tertiary tissue....

Gestational diabetes mellitus (GDM) in human patients disrupts glucose metabolism post-pregnancy, affecting fetal development. Although obesity and genetic factors increase GDM risk, a lack of suitable models impedes comprehensive understanding its pathology. To address this, we administered streptozotocin (STZ, 75 mg/kg) to C57BL/6N mice for two days before pregnancy, establishing convenient model. Pregnant exposed STZ (STZ-pregnant) were compared with STZ-injected virgin (STZ-virgin),...

Systemic autoimmune diseases (ADs) might affect the morphology and function of gut-associated lymphoid tissue (LTs) indirectly; however, their exact relationship remains unclear. Therefore, we investigated mouse LTs in anorectal canal morphologically compared them between MRL/MpJ-Fas+/+ MRL/MpJ-Faslpr/lpr mice. LT aggregations, also known as rectal mucosa-associated tissues (RMALTs), were exclusively seen lamina propria submucosa rectum. The mean size number aggregations both significantly...

1. It has been shown in animals that substance P as well acetylcholine releases endothelium-derived nitric oxide and evokes vasodilatation ATP-induced is partially mediated by oxide. The aim of this study was to examine whether vasodilator effects ATP are humans. 2. In healthy volunteers (n = 35), we measured forearm blood flow a strain-gauge plethysmograph while infusing graded doses acetylcholine, P, or sodium nitroprusside into the brachial artery before after infusion...

We report a case of generalized chronic periodontitis and type 2 diabetes mellitus requiring periodontal treatment including regenerative therapy. The patient was 66-year-old man who presented with the chief complaint gingival inflammation mobile teeth in molar region. He had been being treated for since 1999. His glycated hemoglobin (HbA1c) level 7.8%. An initial examination revealed sites probing depth ≥7 mm region, radiography angular bone defects this area. Based on clinical diagnosis...

We investigated spatiotemporal changes in host tissues during foreign body reactions. Silicone tube was subcutaneously embedded into ICR mice, and tissue surrounding silicone (TSS) observed at 2, 7, 14, 21, 28, 43, 70 days (D) postsurgery. The thin layer (TL) loose connective (LCTs) (inside outside the TSS) developed until D21 densified afterward. Neutrophils infiltrated TSS D14 formed neutrophil extracellular traps (NETs) TL D7-21. In LCTs, mast cell counts increased D21, macrophage numbers...

Abstract This paper examines how the pneumatic biosensing bed works as a network terminal for ubiquitous health monitoring and medical care. A constraint‐free bed, which is an ordinary family optimally equipped with sensing device connected to network, was designed. Heartbeat, respiration, snoring body movements of 32 subjects while in at their homes 14 months were measured transmitted data center via network. The system provided clear, real‐time biosignals on apnea from Sleep Apnea...

The reproductive characteristics and ovarian development in cotton rats ( Sigmodon hispidus , CRs) are unclear, although CRs commonly used as animal models biomedical research. We previously reported that young (6–8 weeks) showed multi-oocyte follicles (MOFs) double nucleated oocytes (DNOs) different stages of follicles. developmental changes neonatal CR ovaries were investigated the present study compared with our findings previous studies unique phenotypes, particularly oocytes. at...

Bones play crucial roles in motility, electrolyte metabolism, and immunity. Clinical cases have suggested bone dysfunction several systemic autoimmune diseases. This study exhibited altered morpho-functions BXSB/MpJ- Yaa as a murine disease model. During clinical examinations, the serum Ca level was significantly higher than healthy control BXSB/MpJ at early stage (two to four months), but that decreased with advancing age. Further, increase of urinary nephritis white blood cells mild anemia...

Abstract The ovarian bursa is a small peritoneal cavity enclosed by the mesovarium and mesosalpinx, which surrounds ovaries oviductal infundibulum in mammals. considered as structure facilitating transport of ovulated oocytes into oviduct. Our previous study revealed reduced oocyte pick‐up function oviduct lupus‐prone MRL/MpJ‐Fas lpr / mouse, suggesting possibility an escape cavity, despite presence almost complete mouse. In this study, we anatomical histological characteristics C57BL/6 N,...

The tear film covers the cornea, and its abnormalities (including immunological) induce dry eye. Using autoimmune disease model mice, BXSB/MpJ- Yaa (BXSB-Yaa), histopathological changes in eye tear-secreting tissues were examined using histopathology, immunohistochemistry, electron microscopy at 8, 20, 28 weeks for early, middle, late stages. Early middle stage BXSB-Yaa showed increased serum autoantibody spleen weight-to-body weight (S/B) ratio, respectively, higher volume than controls,...

Cotton rats are one of the experimental rodents used for testing different infectious and noninfectious diseases, including gastrointestinal tract pathology. However, their intestinal morphological characteristics still poorly understood. Here, we clarified anatomical histological cecum ascending colon (AC) young (1–3-month old), adult (4–6-month-old), old (10–12-month-old) cotton rats. The large intestine (LI) in is composed cecum, AC, transverse descending colons, rectum, similar to that...

Foreign body reaction (FBR) causes unexpected adverse effects due to implanted materials in humans and animals. Inflammation subsequent fibrosis during FBR seems be affected by recipient immunity, such as the balance of T helper (Th) response that has potential regulate FBR-related macrophage function. Here, immunological on subcutaneously imbedded silicone tubes (ST) at 8 weeks were investigated histologically comparing Th1-biased C57BL/6N, Th2-biased MRL/MpJ, autoimmune disease-prone...