A5030167513- Veterinary Oncology Research
- Ultrasound and Hyperthermia Applications
- Cardiovascular Conditions and Treatments
- Liver Disease Diagnosis and Treatment
- Veterinary Medicine and Surgery
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac Valve Diseases and Treatments
- Ultrasound Imaging and Elastography
- Insect and Pesticide Research
- Pulmonary Hypertension Research and Treatments
- Vector-borne infectious diseases
- Tracheal and airway disorders
- Veterinary Equine Medical Research
- Metabolomics and Mass Spectrometry Studies
- Microbial infections and disease research
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- MRI in cancer diagnosis
- Ultrasound and Cavitation Phenomena
- Pancreatitis Pathology and Treatment
- Cancer-related gene regulation
- T-cell and B-cell Immunology
Hokkaido University
2016-2025
Hokkaido University Hospital
2019-2024
Boston Children's Hospital
2023
University of Veterinary Medicine
2019-2020
University Medical Center Utrecht
2015
Osaka Dental University
2002
National Medical Research Center of Dentistry and Maxillofacial Surgery
2001
Gifu University
1983-1991
Hiroshima General Hospital
1986-1988
In six normal beagles and 27 dogs with spontaneous focal or multifocal liver lesions, contrast‐enhanced ultrasonography using Sonazoid ® was performed. is a newly developed second‐generation contrast agent the ability to be used for real‐time imaging along parenchymal imaging. An appropriate protocol evaluation of all three phases (arterial, portal, parenchymal) established based on results beagles. By echogenicity hepatic nodules during arterial it possible differentiate malignant tumors...
Abstract MicroRNAs act as post-transcriptional regulators, and urinary exosome (UExo)-derived microRNAs may be used biomarkers. Herein, we screened for UExo-derived reflecting kidney disease (KD) status in dogs. Examined dogs were divided into healthy control (HC) KD groups according to renal dysfunction. We confirmed the appearance of UExo having irregular globe-shapes a dog by immunoblot detection markers, TSG101 CD9. Based on our previous data using model mice obtained herein next...
Abstract Background In dogs with protein‐losing enteropathy (PLE), data on the clinical characteristics of food‐responsive PLE (FR‐PLE) remain scarce. Objective To determine FR‐PLE in responsive to ultralow‐fat diet (ULFD) management. Animals Thirty‐three diagnosed based standard diagnostic criteria. Methods Retrospective review medical records. Clinical findings were compared between (FR‐PLE group) and those immunosuppressant‐responsive (IR‐PLE) or nonresponsive (NR‐PLE) (IR/NR‐PLE group)....
Background The right ventricular ( RV ) Tei index TX has a significant correlation with the severity of pulmonary hypertension. However, role dysfunction in dogs myxomatous mitral valvular heart disease MMVD not been addressed. Objectives To investigate between Tei‐index RVTX and prognosis for . Animals Thirty client‐owned Methods Clinical cohort study. Dogs were divided into two groups on basis onset cardiac‐related death within 1 year first echocardiographic examination. Physical...
Abstract Background Lymphocytic‐plasmacytic enteritis is the common form of idiopathic inflammatory bowel disease (IBD) in dogs. In human IBD, disturbances amino acid metabolism have been demonstrated to be involved pathophysiology IBD. Therefore, plasma profile might represent a novel marker Objectives To determine profiles dogs with IBD and its usefulness as Animals Fasting blood was obtained from 10 12 healthy Methods All were prospectively included this study, heparinized samples...
We attempted to develop a strain of Babesia gibsoni resistant diminazene aceturate (DA), an anti-babesial drug, in vitro. Since the DA-sensitive B. could survive and proliferate culture medium containing 1 ng/m l DA, concentration DA was gradually increased from 200 ng/ml. The results showed that parasites which much higher than 50% inhibitory (IC50) for gibsoni. Subsequently, these were removed erythrocytes exposed directly ng/ml DA. They able invade fresh erythrocytes, though did not...
Abstract Background Two‐dimensional shear wave elastography (2D‐SWE) can noninvasively evaluate hepatic elastic modulus as velocity (SWV). Additionally, it may predict the presence of clinical relevant fibrosis (≥F2) in dogs with disease. Objectives To investigate whether SWV measured by 2D‐SWE differentiate between and without (F0‐1) clinically fibrosis. Animals Twenty‐eight client‐owned disease 8 normal healthy Beagle were enrolled. Methods In this cross‐sectional prospective study, SWVs...
Contrast-enhanced ultrasonography with perflubutane microbubbles improves the diagnostic accuracy to differentiate benign and malignant focal liver lesions in dogs.Perflubutane microbubbles-enhanced is useful for differentiation of from splenic dogs.Twenty-nine clinical dogs single or multiple detected by conventional ultrasonography.Prospective observational study. Perflubutane was performed 29 lesions. Qualitative assessment enhancement pattern early vascular, late parenchymal phases.In...
Decreased function of the left atrium (LA) is a useful prognostic indicator in dogs with myxomatous mitral valve disease (MMVD). In humans, LA strain novel severity regurgitation, but its clinical utility has not been confirmed.To examine whether as evaluated speckle-tracking echocardiography associated MMVD stage dogs.Fifty-two client-owned MMVD.Cross-sectional study. Dogs were classified B1, B2, C, or D, according to American College Veterinary Internal Medicine consensus. Physical...
In humans with heart disease, vitamin D deficiency is associated disease progression and a poor prognosis. A recent study showed that serum 25-hydroxyvitamin [25(OH)D] concentration, the hallmark of status, was lower in dogs failure than normal dogs, low concentration outcome failure.To elucidate status chronic valvular (CVHD) at different stages severity.Forty-three client-owned CVHD.In this cross-sectional study, were divided into 3 groups (14 Stage B1, 17 B2, 12 C/D) according to ACVIM...
Background Contrast‐enhanced ultrasonography (CEUS) can be used to evaluate intestinal perfusion in healthy dogs. It is helpful for diagnosing and monitoring inflammatory bowel disease humans could useful dogs with chronic diseases. Objectives To examine duodenal enteropathy (CIE) lymphoma. Animals Client‐owned CIE (n = 26) or lymphoma 7) gastrointestinal signs but histopathologically normal duodenum (controls, n 14). Methods In this cross‐sectional study, were classified into remission 16)...
Contrast-enhanced ultrasonography has an important role in the detection of tumors humans. The second-generation contrast agent Sonazoid ability real-time imaging along with parenchymal imaging. purposes this study were to determine effect and duration on changes gray-scale enhancement canine spleen establish appropriate protocol for contrast-enhanced spleen. Six healthy beagles injected intravenous bolus Sonazoid. In parenchyma, was maintained up 30 min after injection. Moreover, 5-22 s...
The stability of the characteristics diminazene aceturate (DA)-resistant B. gibsoni isolate was initially determined in vitro. Part DA-resistant cultured without DA for 4 weeks, and then newly exposed to 200 ng/ml DA. As a result, this could proliferate same as isolate, indicating that characteristic resistance stable isolate. Additionally, level parasitemia comparatively lower than wild-type, suggesting proliferation potential would be wild-type. Subsequently, investigate involvement...
Objectives: To determine the effect of sildenafil for dogs with Eisenmeger's syndrome and secondary erythrocytosis. Methods: This is a prospective, single arm, open-label study. Five clinical erythrocytosis were included. New York Heart Association functional class, packed cell volume, pulmonary artery acceleration time to ejection ratio serum erythropoietin concentration evaluated before after therapy (0·5 mg/kg, twice day). Results: class was significantly improved one (median 2; range 1...
In this pilot study, serum canine pancreatic lipase immunoreactivity was measured repeatedly in dogs with various immune-mediated diseases that were treated immunosuppressive doses of prednisolone.Ten client-owned newly diagnosed disease had normal concentrations (≤200 µg/l) 2 to 2.2 mg/kg prednisolone orally once daily as the initial treatment. Serum samples obtained from each prior treatment and at 1- 4-week intervals during The highest concentration detected defined peak...
Abstract OBJECTIVE To assess liver and spleen stiffness in healthy dogs by use of a novel 2-D shear wave elastography (SWE) technique to investigate the repeatability reproducibility technique. ANIMALS 8 adult Beagles. PROCEDURES SWE was performed on each dog stiffness. Repeatability (intraday variability) (interday were investigated. For all dogs, 3 times 1 day (4-hour intervals) separate days (1-week interval). Data expressed as mean ± SD values for velocity Young modulus spleen. Intraday...
Thus far, there are few computed tomography (CT) characteristics that can distinguish benign and malignant etiologies.The criteria complex, subjective, difficult to use in clinical applications due the high level of experience needed.This study aimed identify practical CT variables their relevance for broadly classifying histopathological diagnoses as or malignant.In this prospective study, all dogs with liver nodules masses underwent examination subsequent diagnosis were...
Quantitative contrast enhanced ultrasound is a major breakthrough for imaging in recent years. However, enhancement of the pancreas brief with bolus injection. To assess if continuous infusion Sonazoid® can prolong duration pancreatic over injections, eight adult dogs received injection and on separate days. Contrast parenchyma proximal descending duodenum was performed, time intensity curves reflecting tissue perfusions were generated. Perfusion parameters- to initial upslope, peak time,...
Background Quantitative contrast‐enhanced ultrasonography ( CEUS ) can detect pancreatic perfusion changes in experimentally induced canine pancreatitis. However, its usefulness detecting naturally occurring pancreatitis is unclear. Hypothesis/Objectives To determine the feasibility of using to and duodenal Animals Twenty‐three client‐owned dogs with pancreatitis, 12 healthy control dogs. Methods Dogs diagnosed were prospectively included. pancreas duodenum performed. Time‐intensity curves...