A5042942360- Heart Rate Variability and Autonomic Control
- Nitric Oxide and Endothelin Effects
- Neuroscience of respiration and sleep
- Renin-Angiotensin System Studies
- Eicosanoids and Hypertension Pharmacology
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Receptor Mechanisms and Signaling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Stress Responses and Cortisol
- Biochemical effects in animals
- Pulmonary Hypertension Research and Treatments
- Neuroendocrine regulation and behavior
- Cardiovascular Disease and Adiposity
- Sodium Intake and Health
- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
- Cardiac Arrhythmias and Treatments
- Adipose Tissue and Metabolism
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Apelin-related biomedical research
- Cardiovascular and exercise physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Electrolyte and hormonal disorders
International University of Health and Welfare
2017-2025
Fukuoka International University
2017-2025
Shirasagi Hospital
2019-2025
Weatherford College
2024
Kyushu University
2010-2019
GTx (United States)
2011-2014
Osaka National Hospital
2011
Universidade de São Paulo
2011
Kyushu University Hospital
2008-2010
Kurume University
2009
A group of patients has been described who have chest pain resembling angina and positive exercise tests, but normal coronary angiograms no coronary-artery spasm. This constellation features sometimes called syndrome X or microvascular angina. We attempted to determine whether endothelium-dependent vasodilatation the vasculature was impaired in with this syndrome.
We examined whether coronary risk factors and atherosclerotic lesions in the study artery were associated with impaired endothelium-dependent dilation of resistance arteries. Acetylcholine (ACH) at graded doses (1, 3, 10 30 micrograms/min) papaverine (10 mg) selectively infused into left anterior descending 28 patients, whom was angiographically normal (n = 16) or mild stenosis < 40% 12). Coronary blood flow (CBF) estimated from product mean CBF velocity measured by an intracoronary Doppler...
Rho-kinase plays an important role in modulating Ca 2+ sensitivity of vascular smooth muscle and has been suggested to be involved the increased systemic resistance hypertensive animals. However, it remains examined whether this is also case patients with essential hypertension. Recently, shown that fasudil a specific inhibitor. The aim study was examine pathogenesis hypertension humans by using Studies were performed (HT group, n=14) age-matched normotensive subjects (NT n=12). Forearm...
Background— Oxidative stress increases in hypertension. The aim of this study was to determine whether reactive oxygen species (ROS) are increased the rostral ventrolateral medulla (RVLM) brainstem, where vasomotor center is located, stroke-prone spontaneously hypertensive rats (SHRSP), and, if so, ROS contribute neural mechanisms hypertension SHRSP. Methods and Results— We measured levels RVLM SHRSP compared them with those Wistar-Kyoto (WKY). Thiobarbituric acid–reactive substances were...
Abstract Hypertensive patients have impaired endothelium-dependent coronary vasodilation evoked with acetylcholine. The aim of this study was to examine whether the dilation arteries is related a specific abnormality muscarinic receptor that mediates effects Responses large epicardial and resistance were assessed in seven hypertensive (mean arterial pressure, 106±14 mm Hg) control subjects (83±6 Hg, P <.01) during cardiac catheterization. To assess endothelial function, we infused...
In this study, we examine the role of NO located in rostral ventrolateral medulla (RVLM) control blood pressure and activity sympathetic nervous system. To determine effect an increase production RVLM on conscious rats, adenovirus vectors encoding either endothelial synthase (AdeNOS) or beta-galactosidase (Adbetagal) were transfected into bilateral RVLM. The local expression (eNOS) protein was confirmed by immunohistochemical staining for eNOS Western blot analysis. Mean arterial (MAP) heart...
Background The pathogenesis of impaired endothelium-dependent coronary vasodilation in angina pectoris and normal arteriograms (microvascular pectoris) is not known. We examined whether supplementation with l -arginine, a precursor endothelium-derived nitric oxide, improves patients microvascular angina. Methods Results effect intracoronary infusion -arginine (50 mg/min) on acetylcholine-induced vasomotion was studied eight control subjects. responses the large epicardial artery diameter...
Long-term treatment with eicosapentaenoic acid (EPA) is known to improve impaired endothelium-dependent relaxations of atherosclerotic blood vessels in animals and humans. However, it remains be determined which mechanisms are involved this beneficial effect EPA. In study, we investigated our hypothesis that EPA improves both nitric oxide (NO)-mediated non-NO-mediated vasodilatation patients coronary artery disease. The study included eight documented forearm vascular responses the...
Background— Rho-kinase is suggested to have an important role in enhanced vasoconstriction animal models of heart failure (HF). Patients with HF are characterized by increased and reduced vasodilator responses reactive hyperemia exercise. The aim the present study was examine whether involved peripheral circulation abnormalities humans inhibitor fasudil. Methods Results— Studies were performed patients (HF group, n=26) age-matched control group (n=26). Forearm blood flow measured a...
Nitric oxide (NO) is shown to be synthesized in the central nervous system as well vascular endothelial cells. However, physiological role of NO cardiovascular regulation remains unclear. The present study examines whether plays a neuronal activity nucleus tractus solitarius (NTS). Single-unit extracellular recordings were obtained from NTS neurons slices (400 microns) rat brainstem, which had spontaneous discharges at frequency 0.5 3 spikes per second. Eighty-one tested for sensitivity...
The present study examined the role of inducible nitric oxide synthase (iNOS) in rostral ventrolateral medulla (RVLM) brain stem, where vasomotor center is located, control blood pressure and sympathetic nerve activity. Adenovirus vectors encoding iNOS (AdiNOS) or beta-galactosidase (Adbetagal) were transfected into RVLM Wistar-Kyoto (WKY) rats. Blood heart rate monitored using a radiotelemetry system. expression was confirmed by immunohistochemical staining Western blot analysis. Mean...
The rostral ventrolateral medulla (RVLM) of the brainstem and paraventricular nucleus (PVN) hypothalamus play crucial roles in central cardiovascular regulation. In hypertensive rats, an imbalance excitatory inhibitory inputs to RVLM enhances sympathetic outflow. Increased reactive oxygen species (ROS) also contribute sympathoexcitation, leading hypertension. aim present study was elucidate whether ROS modulate synaptic transmission via amino acids influence from PVN spontaneously rats...
An important pathogenic mechanism in the development of idiopathic pulmonary arterial hypertension is hypothesized to be a cancer-like cellular proliferation independent haemodynamics. However, because vascular lesions are inseparably coupled with haemodynamic stress, fate unknown when stress eliminated. We applied left artery banding rat model advanced investigate effects decreased on occlusive lesions. Rats were given an injection VEGF blocker Sugen5416 and exposed 3 weeks hypoxia plus...
In metabolic syndrome (MetS), previous studies have suggested that cognitive decline is worsened. Among the factors associated with cognition, decreased brain-derived neurotrophic factor (BDNF) in hippocampus causes decline. We previously reported exercise training calorie restriction yielded protection against via BDNF of hypertensive rats. The aim present study was to determine whether or not results and its receptor tropomyosin-related kinase B (TrkB) MetS model divided dietary-induced...
Abstract —The role of nitric oxide (NO) in the brain control blood pressure and sympathetic nervous system is debated. This study examined effect overexpression endothelial NO synthase (eNOS) nucleus tractus solitarii (NTS) on conscious rats. Adenovirus vectors encoding either eNOS (AdeNOS) or β-galactosidase were transfected into NTS vivo. In AdeNOS-treated rats, local expression was confirmed by immunohistochemical staining Western blot analysis for protein increased production...