A5071404880- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Multiple and Secondary Primary Cancers
- Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Organ Transplantation Techniques and Outcomes
- Genetic factors in colorectal cancer
- High Temperature Alloys and Creep
- Esophageal and GI Pathology
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Research and Treatments
- Cancer-related gene regulation
- Brain Metastases and Treatment
- Bladder and Urothelial Cancer Treatments
Chiba University
2016-2025
Fukui CardioVascular Center
2024
Japanese Red Cross Narita Hospital
2006
Nagano Prefectural Suzaka Hospital
2006
Shonan Institute of Technology
2000-2002
Hepatectomy is standard treatment for colorectal liver metastases; however, it unclear whether metastases from other primary cancers should be resected or not. The Japanese Society of Hepato-Biliary-Pancreatic Surgery therefore created clinical practice guidelines the management metastatic tumors.Eight diseases were selected based on number hepatectomies performed each malignancy per year. Clinical questions structured in population, intervention, comparison, and outcomes (PICO) format....
Krüppel-like factor 5 (KLF5) plays an oncogenic role and has diverse functions in cancer cells. However, correlation between KLF5 clinical outcome not been determined patients with colorectal liver metastasis. Herein, we analyzed 65 who developed Clinical effects were assessed through immunohistochemical analysis of primary lesions metastatic lesions. High expression these tissues correlated the presence vascular invasion, elevated serum carbohydrate antigen 19-9 levels, large diameters...
The exact contribution of preoperative coil embolization in distal pancreatectomy with en bloc celiac axis resection (DP-CAR) for the prevention ischemic liver complication is not fully elucidated.From January 2004 to July 2015, 31 patients underwent DP-CAR pancreatic body-tail cancer. Twenty-three received embolization. characteristics and operative outcomes were analyzed retrospectively.The median survival time 1- 3-year overall rates 23.7 months 74.2% 34.4%, respectively. No 30-day...
The RNA-binding protein LIN28B is overexpressed in over 30% of patients with colorectal cancer (CRC) and associated poor prognosis. In the present study, we unraveled a potentially novel mechanism by which regulates colonic epithelial cell-cell junctions CRC metastasis. Using human cells (DLD-1, Caco-2, LoVo) either knockdown or overexpression LIN28B, identified claudin 1 (CLDN1) tight junction as direct downstream target effector LIN28B. RNA immunoprecipitation revealed that directly binds...
Percutaneous endoscopic gastrostomy (PEG) is commonly performed for enteral nutrition in patients with various diseases. However, there are few reports on abdominal surgeries after PEG, and the tips these procedures have not been established. Specifically, laparoscopic of upper abdomen, a can interfere surgical field. In addition, perioperative management concomitant diseases that require PEG placement, including neuromuscular disorders, required. A 64-year-old man due to malnutrition from...
Although some clinical trials have demonstrated the benefits of neoadjuvant therapy for resectable pancreatic ductal adenocarcinoma (PDAC), its optimal candidate has not been clarified. This study aimed to detect predictive prognostic factors PDAC patients who underwent upfront surgery and identify patient cohorts with long-term survival without therapy.
Abstract Background/Purpose The objective of this study was to determine the frequency and predictors biliary tract cancer (BTC) with deficient DNA mismatch repair (dMMR) in Japan. Methods Immunostaining microsatellite instability analysis were performed for repair‐related proteins tissue specimens from 662 patients who underwent surgery BTC between 2001 2017 identify dMMR‐BTC. We compared dMMR‐BTC proficient MMR (pMMR)‐BTC based on patient demographics, pathological features, host immune...
Yin Yang 1 (YY1) is a multifunctional transcription factor with critical roles in carcinogenesis and metastasis. However, its biological role clinical impact colorectal cancer (CRC) remain unclear. In the present study, function underlying molecular mechanisms of YY1 CRC progression were investigated. The immunohistochemistry (IHC) 143 tissues revealed significant correlation low expression aggressive clinicopathological features, increased metastasis recurrence poor patient survival....
This study aims at establishing benchmark values for best achievable outcomes following open major anatomic hepatectomy liver tumors of all dignities.
Smad ubiquitination regulatory factor 2 (Smurf2) plays various roles in cancer progression. However, the correlation between Smurf2 and clinical outcomes has not been determined patients diagnosed with colorectal liver metastases. We analyzed 66 who developed expression was assessed using immunohistochemical analysis of primary metastatic tumors. High both tumors significantly associated longer overall survival time to surgical failure. Multivariate analyses revealed that low an independent...
Surgical resection is the only hope for cure in patients with pancreatic cancer. To improve resectability and achieve better prognosis of this lethal disease, extended cancer has been applied. We have performed portal vein aggressively invasion. also established a method reconstruction using left renal graft tumors widely to vein. Our data show similar survival between obstruction those without that can be safely severe liver damage. With video, we introduce our surgical technique...
Ring1 and YY‑1 binding protein (RYBP) is a member of the polycomb repressive complex 1 serves as transcriptional suppressor via epigenetic modification. RYBP has tumour‑suppressive role in solid tumours, but its function colorectal cancer (CRC) remains unknown. The present study evaluated expression using immunohistochemistry 140 cases primary CRC 11 patient‑matched liver metastases. Using cell lines with different TP53 gene status such HCT116 (TP53wt/wt), (TP53‑/‑), SW48 DLD‑1 cells,...
Hepatocellular carcinoma (HCC) during pregnancy is rare, with a poor prognosis. Recently, however, increasing resection rates have improved survival rate. Currently, various surgeries are safely performed after the second trimester and termination of not always necessary. However, surgery sometimes limited by gestational age or patient's will. When patients HCC refuse pregnancy, we face specific problems respect to curability fetal life. Meanwhile, previous studies revealed radiofrequency...
Intrahepatic cholangiocarcinoma (ICC) is known to have a high frequency of lymph node metastasis. Lymph dissection (LND) recommended for accurate staging, but the survival benefit LND remains unclear. Knowledge pathways and direction lymphatic drainage regional nodes essential when considering improve patient survival. The liver has three pathways: portal, sublobular, subcapsular. Of these, portal pathway, which lies along with tracts, primary pathway. efferent vessels from left-sided liver,...
Ischemic gastropathy (IG) is a major complication after distal pancreatectomy with en bloc celiac axis resection (DP-CAR) for locally advanced body/tail pancreatic ductal adenocarcinoma (PDAC), and its incidence still unknown. To evaluate the occurrence of IG, 77 18 consecutive patients PDAC were analyzed in retrospective prospective study, respectively. We utilized perioperative gastroendoscopy, Gastrointestinal Quality Life Index (GIQLI) score, quantitative assessment gastric arterial...