<b><i>Background/Aims:</i></b> Megalin mediates the uptake of glomerular-filtered iron in proximal tubules. Urinary full length megalin (C-megalin) excretion has been found to be increased association with megalin-mediated metabolic load endo-lysosomal system tubular epithelial cells (PTECs) residual nephrons. In present study, we investigated between urinary and C-megalin chronic kidney disease (CKD) patients, possible harmful effect renal...

Acute and chronic insomnia can exacerbate type 2 diabetes mellitus (T2DM). We investigated suvorexant (an anti-insomnia drug that targets the orexin system) effects on sleep architecture glucose metabolism in T2DM patients with insomnia.This 7 day open-label, single-arm, intervention trial included 18 subjects insomnia. After 1 acclimatization, daily levels, architecture, autonomic nervous function were evaluated by continuous monitoring (CGM), single-channel electroencephalography,...

Oxidative stress plays a major role in development of cardiovascular disease patients with chronic kidney (CKD). Human mercaptalbumin (HMA), reduced form serum albumin, and non-mercaptalbumin (HNA), an oxidized are known as indicators for evaluating oxidative systemic circulation, including end-stage renal cases. We investigated factors associated fraction HNA [f(HNA)] 112 pre-dialysis CKD (63.6 ± 14.0 years old; 59 males, 53 females) using newly established anion-exchange column packed...

Poor sleep quality is associated with obesity and diabetes. The adipocyte-derived hormone, leptin, was recently shown to underlie the link between abnormal obesity. We aimed investigate association leptin in type 2 diabetes patients.In present cross-sectional study, we studied 182 patients, among whom 113 were diagnosed (body mass index ≥25 kg/m2 ). Fasting plasma levels measured, architecture assessed using single-channel electroencephalography.Using unadjusted analyses, obese but not their...

In primary aldosteronism (PA), aldosterone could affect glomerular hemodynamics by elevating renal vascular resistance and capillary pressure. However, the relationship between plasma concentrations (PAC) including efferent arteriolar (Re), afferent (Ra) in humans is still unclear. The aim of this study was to investigate relationships PAC with intraglomerular hemodynamic parameters patients PA.

Adrenocoricotrophic hormone (ACTH) – independent bilateral adrenocortical macronodular hyperplasia (AIMAH) is a rare cause of Cushing's syndrome, and characterized by adrenal hyperplasia. However, Primary aldosteronism (PA) relatively common disease. A 56-year-old man who has been treated hypertension diabetes mellitus was detected low plasma potassium level with an elevated aldosterone concentration swelling. Endocrinological examinations showed autonomous secretion cortisol aldosterone,...

Abstract Serum 1,25(OH) 2 D and 24,25(OH) are decreased in CKD. Megalin proximal tubular epithelial cells reabsorbs glomerular-filtered 25(OH)D-DBP complex to convert 25(OH)D D. Urinary C-megalin excretion is increased via exocytosis from injured nephrons overloaded with megalin-mediated protein metabolism. This study investigated the significance of urinary vitamin metabolism 153 pre-dialysis CKD patients. was positively associated protein, β MG α 1 MG, exhibited negative correlations serum...

Excess fibroblast growth factor 23 (FGF23) causes hypophosphatemic osteomalacia, which is associated with impaired bone matrix mineralization. Tumor-induced osteomalacia (TIO) a rare paraneoplastic syndrome caused by over-secretion of FGF23 from tumor. Burosumab, fully human monoclonal antibody activities against FGF23, was initially approved in Japan before the rest world for treatment FGF23-associated TIO. We report here patient 15-year history non-remission TIO treated conventional...

Xanthine oxidoreductase (XOR) activity plays an important role as a pivotal source of reactive oxygen species, which is associated with cardiovascular disease (CVD) events. Patients CKD have increased risk CVD In the present study, factors plasma XOR in pre-dialysis patients were investigated.In this cross-sectional 118 (age 68 [57-75] years; 64 males, 26 diabetes mellitus [DM]) was determined using newly established highly sensitive assay based on (13C2,15N2) xanthine and liquid...

Hyperthyroidism is one of the causes secondary osteoporosis, with increased bone turnover and decreased mineral density (BMD). Although antithyroid medication surgical treatment can improve BMD, association calcium intake an increase in postoperative BMD remains unclear. A 51-year-old postmenopausal woman after discontinuation for hyperthyroidism was diagnosed thyrotoxicosis osteoporosis a high risk fracture based on lumbar spine femur BMD. She prescribed drug (methimazole 15 mg/day)...

Pregnancy and lactation-associated osteoporosis (PLO) is one of the rarest most serious primary osteoporotic conditions that develops during third trimester gestation and/or early postpartum period. A history PLO often causes individuals to hesitate when considering an additional child due anxiety about recurrence risk. Reported here are details a 29-year-old patient with given aggressive treatment for teriparatide who subsequently gave birth healthy at age 33 without recurrence. Further...

An association of higher levels β-hydroxybutyrate (β-HB) in serum with greater mortality hemodialysis (HD) patients has been reported. This study examined the significance arterial ketone body ratio (AcAc/β-HB), a relevant marker energy state, HD patients.The AcAc and β-HB, AcAc/β-HB were determined 49 just before undergoing an session. Additionally, changes those during session to investigate their associations clinical nutritional markers.Arterial but not AcAc, was significantly at...

Bexarotene-induced central hypothyroidism (CH), for which levothyroxine (LT4) replacement is recommended, has been shown to be caused by pituitary but not hypothalamic disorder experimentally, though the underlying mechanism in humans remains unclear. Here, pathophysiology of bexarotene-induced CH was examined using a TRH stimulation test cutaneous T-cell lymphoma (CTCL) patients. In this retrospective longitudinal observational study, serum TSH and free T4 (F-T4) levels were measured 10...

Picture 2.T1-weighted in-phase image T1-weighted opposed-phase T2-weighted

Insufficient sleep has been recognized to underlie the epidemic of obesity, type 2 diabetes, hypertension, and cardiovascular diseases. Recent evidence indicates that, not only short duration, but also poor quality is associated with metabolic syndrome. However, most prior studies evaluated subjectively by using a questionnaire. In this study, we objectively investigated its association obesity in patients diabetes. We included 182 which 113 had (BMI ≥ 25kg/m2). Objective architecture was...

Abstract Background: An association of higher levels b-hydroxybutyrate (b-HB) in serum with greater mortality hemodialysis (HD) patients has been reported. This study examined the significance arterial ketone body ratio (AcAc/b-HB), a relevant marker energy state, HD patients. Methods: The AcAc and b-HB, AcAc/b-HB were determined 49 just before undergoing an session. Additionally, changes those during session to investigate their associations clinical nutritional markers. Results: Arterial...

Abstract Background: An association of higher levels b-hydroxybutyrate (b-HB) in serum with greater mortality hemodialysis (HD) patients has been reported. This study examined the significance arterial ketone body ratio (AcAc/b-HB), a relevant marker energy state, HD patients. Methods: The AcAc and b-HB, AcAc/b-HB were determined 49 just before undergoing an session. Additionally, changes those during session to investigate their associations clinical nutritional markers. Results: Arterial...

Abstract Background: An association of higher levels b-hydroxybutyrate (b-HB) in serum with greater mortality hemodialysis (HD) patients has been reported. This study examined the significance arterial ketone body ratio (AcAc/b-HB), a relevant marker energy state, HD patients. Methods: The AcAc and b-HB, AcAc/b-HB were determined 49 just before undergoing an session. Additionally, their changes during session to investigate associations clinical nutritional markers. Results: Arterial but not...

Abstract Background: An association of higher levels β-hydroxybutyrate (β-HB) in serum with greater mortality hemodialysis (HD) patients has been reported. This study examined the significance arterial ketone body ratio (AcAc/β-HB), a relevant marker energy state, HD patients. Methods: The AcAc and β-HB, AcAc/β-HB were determined 49 just before undergoing an session. Additionally, changes those during session to investigate their associations clinical nutritional markers. Results: Arterial...

Acquired fibroblast growth factor (FGF) 23-related hypophosphatemic osteomalacia is characterized clinically by muscle weakness, bone pain, and fractures. Its biochemical features include hypophosphatemia, caused renal phosphate wasting, inappropriately normal or low 1,25-dihydroxy-vitamin D levels. Recently, burosumab, a fully human monoclonal antibody targeting FGF23, was approved for the treatment of FGF23-related rickets osteomalacia. We report case 75-year-old Japanese woman with...