A5036288374- IgG4-Related and Inflammatory Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Disease and Adiposity
- Liver Disease Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Neuroendocrine Tumor Research Advances
- Heme Oxygenase-1 and Carbon Monoxide
- Parathyroid Disorders and Treatments
- Gout, Hyperuricemia, Uric Acid
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Imaging and Diagnostics
- Renin-Angiotensin System Studies
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Alcohol Consumption and Health Effects
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Cardiac Structural Anomalies and Repair
- Kawasaki Disease and Coronary Complications
- Nitric Oxide and Endothelin Effects
- Pancreatitis Pathology and Treatment
- Eicosanoids and Hypertension Pharmacology
- Coronary Interventions and Diagnostics
- Gastrointestinal disorders and treatments
- Heart Failure Treatment and Management
Doai Memorial Hospital
2024
Osaka Medical and Pharmaceutical University
2013-2022
Saga University
2020
Hokkaido University Hospital
2020
Wake Forest University
2019
Forest Institute
2019
Charlottesville Medical Research
2019
John Wiley & Sons (United States)
2019
Institute of Cardiology
2017
Toyohashi Heart Center
2013
Superoxide anion formation is vital to the microbicidal activity of phagocytes. Recently, however, there accumulating evidence that it also involved in cell growth vascular smooth muscle cells (VSMCs). We have shown hypertrophic agent angiotensin II stimulates superoxide production by activating membrane-bound NADH/NADPH oxidase and inhibition this attenuates hypertrophy. However, molecular identity VSMCs unknown. recently cloned cytochrome b558 alpha-subunit, p22(phox) (one key electron...
Abstract —Atherosclerotic lesions are found opposite vascular flow dividers at sites of low shear stress and oscillatory flow. Since endothelial proinflammatory genes prominent in regulated by oxidation-sensitive transcriptional control mechanisms, we examined the redox state cultured human umbilical vein cells after either or steady laminar fluid stress. Endothelial oxidative was assessed measuring activity superoxide (O 2 · − )–producing NADH oxidase (a major source reactive oxygen species...
Recent studies suggest that superoxide production by the NADPH/NADH oxidase may be involved in smooth muscle cell growth and pathogenesis of hypertension. We previously showed angiotensin II (Ang II) activates a p22phox-based cultured rat vascular cells animals made hypertensive infusion Ang II. To investigate mechanism responsible for this increased activity, we examined p22phox mRNA expression rats implanting an osmotic minipump delivered (0.7 mg/kg per day). Blood pressure began to...
IgG4-related disease (IgG4-RD) is a fascinating clinical entity first reported in this century Japan, and includes wide variety of diseases, such as formerly named Mikulicz's (MD), autoimmune pancreatitis (AIP), interstitial nephritis, prostatitis retroperitoneal fibrosis. The Japanese IgG4 team organized by the Ministry Health, Labor Welfare (MHLW) Japan has published criteria, comprehensive diagnostic (CD) criteria for IgG-RD 2011. Thereafter, IgG4-RD been accepted widely many cases have...
Increasing experimental evidence suggests that non-phagocytic cells express a potent superoxide (O2-•)-producing NADH oxidase might be related to the phagocytic NADPH oxidase. Here we show cytokine tumour necrosis factor α (TNF-α) activates, in time- and dose-dependent manner, O2-•-producing cultured rat aortic smooth-muscle cells. Dose-response experiments for showed an upward shift of curve TNF-α-treated cells, suggesting TNF-α increased amount available enzyme. Using anti-sense...
There are few data available on possible independent association between uric acid and carotid atherosclerosis. Here we first sought to investigate levels metabolic syndrome in Japanese; second, assessed whether there is an of with prevalence atherosclerosis individuals subdivided according gender status.Cross-sectional from 8144 who underwent general health screening were analyzed. After adjusting for age, total cholesterol, smoking status, the odds ratios (95% CI) sex-specific quartiles...
The klotho gene, originally identified by insertional mutagenesis in mice, suppresses the expression of multiple aging-associated phenotypes. This gene is predominantly expressed kidney. Recent studies have shown that renal regulated animal models metabolic diseases and humans with chronic failure. However, little known about mechanisms physiological relevance regulation kidney some diseased conditions. In present study, we first investigated role angiotensin II expression. Long-term...
Abstract —Caveolae are membrane domains that have been implicated in signal transduction, and caveolins major structural components of these domains. We found all reported caveolin isoforms (caveolin-1, -2, -3) were expressed vascular smooth muscle cells (VSMCs); however, only caveolin-1 mRNA was regulated by angiotensin II (Ang II). Ang (100 nmol/L) increased mRNA, with a peak at 2 hours (193±6% control, P <0.01, n=4). In contrast, significantly decreased protein, nadir 4 (64±5% n=6). [...
Monocyte chemoattractant protein-1 (MCP-1), a potent monocyte synthesized by vascular cells and monocytes, has been proposed to be an important mediator of inflammatory responses in the arterial vasculature. It was recently demonstrated that hypertension is associated with response wall. To determine effect on MCP-1 expression, we induced Sprague-Dawley rats infusing angiotensin II (0.75 mg x kg[-1] d[-1] SC) for 7 days. Using Northern blot analysis, detected 3.6-fold increase mRNA aortas...
An elevated level of serum uric acid (SUA) is associated with an increased risk cardiovascular disease. Pharmacological intervention urate-lowering agents, such as the conventional purine analogue xanthine oxidase (XO) inhibitor, allopurinol, has been used widely for a long period time in clinical practice to reduce SUA levels. Febuxostat, novel non-purine selective inhibitor XO, higher potency inhibition XO activity and greater efficacy than allopurinol. However, evidence regarding effects...
Objective— Heme oxygenase (HO) is important in the defense against oxidative stress and as a factor an antiatherogenic mechanism. Compared with long (GT) n repeats, short repeats human HO-1 gene promoter were shown to have higher transcriptional activity response stress. There strong link between pathogenesis of coronary artery disease (CAD). Methods Results— We screened allelic frequencies 577 patients who underwent angiography. Because distribution numbers was bimodal, we divided alleles...
Carbon monoxide (CO) is postulated to protect tissues against several types of injuries. We investigated the role CO in amelioration cardiac ischemia-reperfusion injury vivo and mechanisms involved it.Rats inhaled (250 ppm, 500 or 1000 ppm) for 24 hours a chamber after myocardial induced by occluding left anterior descending coronary artery 30 minutes. Pre-exposure ppm significantly reduced ratio infarct areas risk suppressed migration macrophages monocytes into areas, expression tumor...
In this study, we investigated the regulation and physiological role of heme oxygenase-1 (HO-1) in kidney rats with hypertension. Rats were continuously administered either angiotensin II (Ang II) or norepinephrine an osmotic minipump for up to 7 days. Ang infusion decreased glomerular filtration rate (GFR) as determined through creatinine clearance (3.2+/-0.2 versus 1.2+/-0.2 mL/min infusion, P<0.01) increased proteinuria (9. 7+/-1.3 28.1+/-7.2 mg/d P<0.01). contrast, did not alter these...
We investigated the in vivo effects of angiotensin (Ang) II-induced hypertension on heme oxygenase (HO) mRNA and protein expression, activity, localization rat aortas.Infusion Ang II (0.7 mg x kg(-1) d(-1)) increased HO-1 levels to 169+/-31%, 251+/-47%, 339+/-26%, 370+/-74% control level at 1, 3, 5, 7 days after operation, respectively. The was markedly upregulated, as HO activity. Treatment with either losartan (25 or hydralazine (15 d(-1)), both which prevented hypertension, blocked...
A link between certain infectious microorganisms and an increased risk of atherosclerotic disease has been suggested. By analyzing the data subjects who had undergone general health-screening tests, a possible association carotid atherosclerosis seropositivity antibody against hepatitis C virus (HCV) previously reported. In present study, HCV core protein positivity was assessed, because it is postulated to be better marker viremia thus persistent infection. Of 1992 enrolled subjects, 496...
Recent experimental and epidemiological findings suggest that some infectious agents play a role in the development promotion of atherosclerosis. We have investigated possible association between hepatitis B virus surface antigen (HBsAg) positivity carotid arteriosclerosis.In this cross-sectional cohort study, we analyzed data from subjects undergoing general health-screening tests, including both high-resolution B-mode ultrasound assessment HBsAg status, 1994 2001 at our institute. Of 4686...
Objective. Studies have shown that obesity is associated with an increase in serum uric acid; and few data are available on the relationship between changes measures of acid concentrations. We investigated among percentage waist circumference (%dWC), body mass index (%dBMI), (%dUA). Methods. The 3153 individuals [1968 men, 1185 women (536 premenopausal, 649 postmenopausal)] who underwent general health screening over a 2-year period were not taking antihyperuricemic medication analyzed....