A5102888412- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Diabetes Treatment and Management
- Obstructive Sleep Apnea Research
- Peripheral Artery Disease Management
- Cardiac Imaging and Diagnostics
- Gout, Hyperuricemia, Uric Acid
- Heart Failure Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hemodynamic Monitoring and Therapy
- Lipoproteins and Cardiovascular Health
- Sodium Intake and Health
- Cardiovascular and Diving-Related Complications
- Hormonal Regulation and Hypertension
- Cardiovascular and exercise physiology
- Liver Disease Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Metabolism, Diabetes, and Cancer
- Thermoregulation and physiological responses
- Inflammasome and immune disorders
- Diet and metabolism studies
Tokyo Medical University
2015-2024
Tokyo Medical University Hospital
2012-2023
Japan Pediatric Society
2023
Saga University
2020
Hiroshima University
2012-2017
Kyushu University
2017
Hiroshima University Hospital
2012
National Defense Medical College
2012
The University of Tokyo
2005-2012
Kajima Corporation (Japan)
2005-2007
Arterial stiffness is an important risk factor for cardiovascular disease. Carotid-femoral pulse wave velocity (cfPWV) the most recognized and established index of arterial stiffness. An emerging automatic measure PWV primarily used in Asian countries brachial-ankle (baPWV).To systematically compare these two methodologies, we conducted a multicenter study involving total 2287 patients.There was significant positive relation between baPWV cfPWV (r = 0.73). Average approximately 20% higher...
Aortic stiffness, as assessed by carotid-femoral pulse wave velocity, is an independent predictor of future events in individuals with hypertension. Recent data suggest a predictive role estimated velocity (ePWV) calculated previously published equations using age and blood pressure hypertension.To investigate whether ePWV its response to treatment predict survival the Systolic Blood Pressure Intervention Trial (SPRINT).This exploratory, hypothesis-generating, post hoc secondary analysis...
Although cells of the osteoblast lineage express functional ERs, direct effects estrogen on bone formation remain obscure. In present study, we have investigated osteoblastic and adipocytic differentiation from a mouse marrow stromal cell line, ST-2, which had been manipulated to overexpress either human ERα (ST2ERα) or ERβ (ST2ERβ). Treatment with morphogenetic protein-2 increased alkaline phosphatase activity as well number Oil Red O-positive adipocytes, indicating that stimulated both...
Background Although a very simple method of measuring brachial - ankle pulse wave velocity (baPWV) has become available in clinical setting, whether baPWV can predict future cardiovascular events remains uncertain. We examined is predictor patients with acute coronary syndrome (ACS). Methods and Results measurement was performed 215 consecutive ACS. During the follow-up period (26±10 months), 46 experienced post-hospitalization (18 major event (eg, stroke, re-admission for heart failure or...
<h3>Objective</h3> To determine the relationships between flow-mediated vasodilation (FMD) and cardiovascular risk factors, to evaluate confounding factors for measurement of FMD in a large general population Japan. <h3>Methods</h3> This was cross-sectional study. A total 5314 Japanese adults recruited from people who underwent health screening 1 April 2010 31 August 2012 at 3 hospitals Patients' (age, Body Mass Index, blood pressure, cholesterol parameters, glucose level HbA1c level)...
Background— Patients with Gilbert syndrome have mild unconjugated hyperbilirubinemia. It has been shown that bilirubin is an endogenous antioxidant. We evaluated the role of oxidative stress in endothelial function patients under normal conditions without cardiovascular risk factors. Methods and Results— A total 108 young men factors age-matched healthy (normal controls) were enrolled this study. Serum concentrations higher than control subjects (29.2±11.6 versus 9.4±2.7 μmol/L; P...
Background The usefulness of vascular function tests for management patients with a history coronary artery disease is not fully known. Methods and Results We measured flow‐mediated vasodilation ( FMD ) brachial–ankle pulse wave velocity (ba PWV in 462 assessment the predictive value ba future cardiovascular events prospective multicenter observational study. first primary outcome was events, second composite stroke, heart failure, sudden death. During median follow‐up period 49.2 months,...
Background Diagnostic criteria of flow‐mediated vasodilation (FMD), an index endothelial function, and nitroglycerin‐induced (NID), vascular smooth muscle the brachial artery have not been established. The purpose this study was to propose diagnostic FMD NID for normal function function. Methods Results We investigated cutoff values in subjects with (risk group) those without cardiovascular risk factors or diseases (no‐risk 7277 Japanese (mean age 51.4±10.8 years) from Flow‐Mediated Dilation...
An elevated level of serum uric acid (SUA) is associated with an increased risk cardiovascular disease. Pharmacological intervention urate-lowering agents, such as the conventional purine analogue xanthine oxidase (XO) inhibitor, allopurinol, has been used widely for a long period time in clinical practice to reduce SUA levels. Febuxostat, novel non-purine selective inhibitor XO, higher potency inhibition XO activity and greater efficacy than allopurinol. However, evidence regarding effects...