A5076619077- Neuroendocrine regulation and behavior
- CRISPR and Genetic Engineering
- Genetic Mapping and Diversity in Plants and Animals
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Viral Infectious Diseases and Gene Expression in Insects
- Gene expression and cancer classification
- Monoclonal and Polyclonal Antibodies Research
- Animal Behavior and Welfare Studies
- Gene Regulatory Network Analysis
- Genetic and phenotypic traits in livestock
- Animal Ecology and Behavior Studies
- Genomics and Chromatin Dynamics
- Neurotransmitter Receptor Influence on Behavior
- Animal Genetics and Reproduction
- Neuropeptides and Animal Physiology
- Down syndrome and intellectual disability research
- Zebrafish Biomedical Research Applications
- melanin and skin pigmentation
- HER2/EGFR in Cancer Research
- Single-cell and spatial transcriptomics
- dental development and anomalies
- Congenital heart defects research
- Pharmacogenetics and Drug Metabolism
- Neurobiology and Insect Physiology Research
RIKEN Center for Biosystems Dynamics Research
2020-2024
Nagoya University
2024
National Institute of Genetics
2011-2020
Nitto RIKEN (Japan)
2019
Research Organization of Information and Systems
2015-2017
The Graduate University for Advanced Studies, SOKENDAI
2009-2014
Nippon Soken (Japan)
2009-2010
Abstract Group-housed male mice exhibit aggressive behaviour towards their cage mates and form a social hierarchy. Here, we describe how hierarchy in standard group-housed conditions affects gene expression mice. Four C57BL/6 were kept each used the study, was determined from observation of video recordings behaviour. After formation hierarchy, hippocampal analysed Higher anxiety- depression-like behaviours elevated hypothalamic corticotropin-releasing hormone serotonin receptor subtypes...
Canonical epidermal growth factor (EGF) receptor (EGFR) activation involves the binding of seven EGFR ligands (EGFRLs); however, their extracellular dynamics remain elusive. Here, employing fluorescent probes and a tool for triggering ectodomain shedding, we show that epiregulin (EREG), low-affinity EGFRL, rapidly efficiently activates in Madin-Darby canine kidney (MDCK) epithelial cells mouse epidermis. During collective cell migration, signal-regulated kinase (ERK) waves propagate an...
Abstract Astrocytes exert adverse effects on the brains of individuals with Down syndrome (DS). Although a neurogenic-to-gliogenic shift in fate-specification step has been reported, mechanisms and key regulators underlying accelerated proliferation astrocyte precursor cells (APCs) DS remain elusive. Here, we established human isogenic cell line panel based DS-specific induced pluripotent stem cells, XIST -mediated transcriptional silencing system trisomic chromosome 21,...
Many animal species have been domesticated over the course of human history and became tame as a result domestication. Tameness is behavioral characteristic with 2 potential components: (1) reluctance to avoid humans (2) motivation approach humans. However, specific characteristics selected during domestication processes remain be clarified for many species. To quantify these different components tameness separately, we established 3 tests: 'active tame', 'passive tame' 'stay-on-hand' tests....
Abstract Tameness is a major behavioral factor for domestication, and can be divided into two potential components: motivation to approach humans (active tameness) reluctance avoid (passive tameness). We identified genetic loci active tameness through selective breeding, selection mapping, association analysis. In previous work using laboratory wild mouse strains, we found that strains were predominantly selected passive but not during their domestication. To identify regions associated with...
Abstract Wild mouse strains have been used for many research studies, because of the high level inter-strain genetic and phenotypic variations in them, addition to characteristic phenotype maintained from wild mice. However, since application current engineering method on is not easy, there are limited studies that attempted apply gene modification techniques strains. Recently, i -GONAD, a new genome editing does involve any ex vivo manipulation unfertilized or fertilized eggs has reported....
Black coat color (nonagouti) is a widespread classical mutation in laboratory mouse strains. The intronic insertion of endogenous retrovirus VL30 the
Domesticated animals such as dogs and laboratory mice show a high level of tameness, which is important for humans to handle them easily. Tameness has two behavioral components: reluctance avoid (passive tameness) motivation approach (active tameness). To quantify these components in mice, we previously developed tests active passive the willingness stay on human hand, each designed be completed within 3 min. The data obtained were used selective breeding, with large number analyzed per...
Hybridization and backcrossing of native populations with introduced species can lead to introgression genetic alteration. In this study, we evaluated in 43 deer from a potential hybrid zone around Okinoshima Island, Kinki District, Japan. This region witnessed the migration population (cross between Formosan sika [Cervus nippon taiouanus] other species) that could potentially breed Japanese (C. n. centralis). We used an existing marker for mitochondrial cytochrome b gene two novel markers...
Summary Epidermal growth factor receptor ligands (EGFRLs) consist of seven proteins. In stark contrast to the amassed knowledge concerning epidermal receptors themselves, extracellular dynamics individual EGFRLs remain elusive. Here, employing fluorescent probes and a tool for triggering ectodomain shedding EGFRLs, we show that EREG, low-affinity EGFRL, exhibits most rapid efficient activation EGFR in confluent epithelial cells mouse epidermis. Madin-Darby canine kidney (MDCK) renal cells,...
Two coat-color mutations, nonagouti, which changes coat color from wild-type agouti to black, and piebald, induces irregular white spotting, are the characteristics of Japanese fancy mouse strain JF1/Ms. In our Communications Biology article, we reported that insertion a rare type endogenous retrovirus β4 has caused both mutations. Although there some reports on roles in genome, further studies will uncover new features sequences. light their recent finding retrovirus, β4, is cause...
validity of both our viral vector and distinct long-lasting mechanisms NPS.In sum, NPS remains an attractive candidate for novel compounds targeting anxiety pathophysiology.
validity of both our viral vector and distinct long-lasting mechanisms NPS.In sum, NPS remains an attractive candidate for novel compounds targeting anxiety pathophysiology.