A5080183741- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Viral-associated cancers and disorders
- Viral gastroenteritis research and epidemiology
- Parvovirus B19 Infection Studies
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Hepatitis Viruses Studies and Epidemiology
- Infectious Encephalopathies and Encephalitis
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Polyomavirus and related diseases
- Kawasaki Disease and Coronary Complications
- Toxoplasma gondii Research Studies
- HIV Research and Treatment
- Urticaria and Related Conditions
- Mast cells and histamine
- Plant and Fungal Species Descriptions
- Food Allergy and Anaphylaxis Research
- Lymphoma Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Bartonella species infections research
- Neurological Complications and Syndromes
University of California, Davis
2021-2024
Fujita Health University
2015-2024
Aomori Prefectural Local Museum
2024
Fujita Health University Hospital
2016-2023
Human herpesvirus 6B (HHV-6B) is the causative agent for exanthem subitum. HHV-6B was associated with mesial temporal sclerosis (MTS), leading to lobe epilepsy (MTLE). In this study, we sought elucidate pathogenic role of in patients MTLE.Seventy-five intractable MTLE patients, including 52 MTS and 23 non-MTS were enrolled study. Resected hippocampus, amygdala, mixed samples amygdala uncus examined by real-time polymerase chain reaction (PCR) reverse-transcriptase PCR detect viral DNA...
This study was conducted to assess the transmissibility of rotavirus vaccine strains after vaccination in a neonatal intensive care unit (NICU).Pentavalent (RV5) or monovalent (RV1) administered infants admitted NICU. Nineteen vaccinated and 49 unvaccinated whose beds were located close proximity enrolled this study. Dissemination fecal shedding viruses within NICU examined using real-time reverse transcription-polymerase chain reaction.Shedding strain detected all 19 infants. RV5 virus...
Human herpesvirus 6 (HHV-6) can be genetically transmitted from parent to child as inherited chromosomally integrated HHV-6 (iciHHV-6). reactivation occurs in pregnant women with iciHHV-6. We found no sex differences the frequency of index cases iciHHV-6 but inheritance father was more common. evaluated association between status and spontaneous abortion.iciHHV-6 confirmed by high viral DNA copy numbers whole blood somatic cells. The origin genome, paternal or maternal, examined using same...
Sequences homologous to human herpesvirus 6 (HHV-6) are integrated within the nuclear genome of about 1% humans, but it is not clear how this came about. It also uncertain whether HHV-6 can reactivate into an infectious virus. integrates telomeres, and has recently been associated with polymorphisms affecting MOV10L1. MOV10L1 located on subtelomere chromosome 22q (chr22q) required make PIWI-interacting RNAs (piRNAs). As piRNAs block germline integration transposons, piRNA-mediated repression...
The objectives of the work are to elucidate incidence and virological findings chromosomally integrated human herpesvirus 6 (ciHHV-6) in Japanese population analyze an association between ciHHV-6 clinical manifestation exanthema subitum (ES). Real-time polymerase chain reaction was performed determine HHV-6 DNA loads 2347 cord blood samples from healthy neonates (cohort A), febrile children less than 5 years old B), hematopoietic cell transplant recipients C). CiHHV-6 confirmed by detection...
It is still a matter of debate whether detection Epstein–Barr virus ( EBV ) DNA in pretreatment serum has clinical implications for diffuse large B‐cell lymphoma. For this study, we measured load from 127 lymphoma patients without any underlying immunodeficiency to evaluate its effects on manifestations and prognosis. Anthracycline‐based chemotherapy combination with rituximab was given as initial therapy 119 (94%). detected 15 (12%), who were older P = 0.005) tended be at more advanced...
We analyzed serially collected serum samples from healthy adults who underwent BNT162b2 vaccination to elucidate the association between spike (S)-IgG antibody titers determined by ELISA using WHO international standard (NIBSC code 20/136) and neutralizing against three live SARS-CoV-2 variants. This study included 53 health care workers received two doses of vaccine. S-IgG nucleocapsid (N)-IgG were measured ELISA. Neutralizing (NT) responses variants (Wuhan D614 G: KUH003, Alpha, Delta)...
This cohort study, based on the design of a prior study in United States, was conducted to elucidate clinical features primary human herpesvirus-6B (HHV-6B) infection.Between June 2014 and May 2016, febrile children younger than 5 years who visited emergency room (ER) underwent blood examination were enrolled this study.Fifty-nine (12%) 491 patients diagnosed with HHV-6B infection. The rates both simple complex seizure significantly higher infection those without (P < 0.001 P = 0.008,...
Kaposi sarcoma-associated herpesvirus (KSHV) inflammatory cytokine syndrome (KICS) is a newly described chronic disease condition caused by KSHV infection and characterized high viral load sustained elevations of serum KSHV-encoded IL-6 (vIL-6) human (hIL-6). KICS has significant immortality greater risks other complications, including malignancies. Although prolonged vIL-6 exposure persistent expected to have key roles in subsequent development, the biological effects remain elusive. Using...
Hemophagocytic lymphohistiocytosis (HLH) is a life threatening hematological disorder associated with severe systemic inflammation caused by an uncontrolled and ineffective immune response resulting in cytokine storm. Epstein-Barr virus (EBV) the most common infectious agent patients viral-associated HLH. Limited numbers of cases cardiac complication have been demonstrated other HLH patients. Herein, we report pediatric case EBV-associated complications. A previously healthy 4-year-old...
We analyzed 3 hematopoietic stem cell transplant (HSCT) recipients with inherited chromosomally integrated human herpesvirus-6 (inherited CIHHV-6). Cases 1 CIHHV-6A) and 2 CIHHV-6B) were CIHHV-6 recipients. Case received bone marrow from a donor CIHHV-6B. Following HSCT, HHV-6B was isolated 1. HHV-6A -6B messenger RNAs detected in 3.
Rotavirus (RV) is a leading cause of gastroenteritis in children. In Japan, Rotarix (RV1; GlaxoSmithKline), which monovalent vaccine derived from human RV (G1P[8]), has been introduced since November 2011, and RotaTeq (RV5; MSD) an pentavalent, human-bovine mono-reassortant (G1, G2, G3, G4, P1A[8]), July 2012. Long-term follow-up on efficacy genotypical change should be carried out order to control infection. The (RVGE) outbreak occurred during the 2018/2019 season Aichi prefecture, Japan....
We encountered a previously healthy 3-year-old girl with interstitial pneumonitis that initially developed due to human adenovirus type 2 infection and exacerbated by primary herpesvirus 7 infection. A comprehensive serum biomarker analysis showed patterns differed viral infection, suggesting respiratory lymphotropic infections might have different pathophysiology in pneumonitis.
Integration of the complete human herpesvirus 6 (HHV-6) genome into telomere a chromosome has been reported in some individuals (inherited chromosomally integrated HHV-6; iciHHV-6). Since proportion iciHHV-6-positive with integration 22 is high Japan, we hypothesized founder effect. In this study, sought to elucidate reason for viral integrations 22. We analyzed six cases iciHHV-6A and two iciHHV-6B, including one case matched sample from father iciHHV-6B mother. iciHHV-6A, same copy numbers...
RotaTeq (RV5) is a widely used live attenuated pentavalent rotavirus (RV) vaccine. Although fecal shedding of RV vaccine strains persists for long time periods, it unclear how each strain replicates in intestinal tissue and excreted stool. To examine this issue, we established RV5 genotype-specific real-time reverse transcription-PCR (RT-PCR) assays. Five RT-PCR assays were designed the VP7 gene genotypes G1, G2, G3, G4, G6. All exhibited excellent linearity, detection limit was 1 infectious...
Although myelosuppression caused by human herpesvirus 6B (HHV-6B) reactivation in transplant recipients has been extensively investigated, the pathophysiological mechanisms of severe neutropenia primary HHV-6B infection remain unclear.Fifty-four patients with were evaluated. Hematological examinations and blood sampling conducted on days 1-4 (pre) 5-10 (post) after onset illness. Severe was defined as a neutrophil count less than 500 cells/μL. Patient characteristics, clinical data,...
Previous studies have demonstrated the transmission of rotavirus vaccine strains from vaccinated children to nonvaccinated siblings. We sought fully elucidate safety (RV) vaccination in closed contact circumstance, such as foster home for future assessment an neonatal intensive care unit. Stool samples were collected 4 RV (160 samples) and 23 unvaccinated (766 infants. viral RNA loads measured using real-time reverse transcription polymerase chain reaction (RT-PCR). strain was persistently...
Aggressive systemic mastocytosis (ASM) is a rare malignant disease characterized by disordered mast cell accumulation in various organs. We here describe female ASM patient with previous history of ovarian dysgerminoma.Molecular cytogenomic analyses were performed to elucidate an etiological link between the and dysgerminoma patient.This was affected which treated chemotherapy surgical resection. Having subsequently been complete remission for 2 years, she developed symptoms ASM. A somatic...
Abstract MSUD is an autosomal recessive condition characterized by a deficiency in the enzyme, BCKDH, which catalyzes breakdown of BCAAs. If left untreated, can result mental retardation, central nervous system disorders, and even death. Most patients with are treated restricted protein diet milk from BCAAs have been removed. LT has shown effective MSUD. This report describes case 15‐month‐old boy who received liver graft his mother. Transplantation was successful, patient then able to...
Abstract Objective The main aims of the present study were to elucidate systemic group A rotavirus (RVA) infection and clarify genetic changes persistent virus in X‐linked severe combined immunodeficiency (SCID) patient. Methods RotaTeq vaccine (RV5) genotype‐specific real‐time reverse transcription polymerase chain reaction was used monitor viral RNA load serially collected serum stool samples. Next‐generation sequence analysis determine genotype by sequencing 11 gene segments....