A5090348896- Neuroblastoma Research and Treatments
- Cancer therapeutics and mechanisms
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Autoimmune and Inflammatory Disorders Research
- Cancer, Hypoxia, and Metabolism
- Lymphoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Virus-based gene therapy research
- Sarcoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Chronic Myeloid Leukemia Treatments
- Erythrocyte Function and Pathophysiology
- Blood disorders and treatments
- Adolescent and Pediatric Healthcare
- Parvovirus B19 Infection Studies
- Viral-associated cancers and disorders
- RNA modifications and cancer
- Eosinophilic Disorders and Syndromes
- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- COVID-19 Impact on Reproduction
- CNS Lymphoma Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Neurological Complications and Syndromes
National Center for Global Health and Medicine
2016-2025
Japan Cancer Society
2024
Center for Global Health
2016-2023
Nihon University
2008-2018
Juntendo University
2016
Saitama International Medical Center
2015
Pediatrics and Genetics
2009-2015
Nihon University Itabashi Hospital
2013
Surugadai Nihon University Hospital
2004
Abstract Background We aimed to reveal the transmission rate of coronavirus disease 2019 (COVID‐19) and clinical features congenital neonatal COVID‐19 disclose efficacy maternally transferred antibodies by maternal vaccination against severe acute respiratory syndrome 2 (SARS‐CoV‐2). Methods This multicenter, prospective observational study included a comprehensive testing protocol with appropriate precautions. Mothers infants were enrolled classified into an active infection group (mothers...
The importance of early diagnosis in infants with a mild form Hunter's syndrome should be emphasized. If applied sufficiently early, haematopoietic stem cell transplantation (HSCT) or recombinant enzyme therapy may improve the prognosis. At present, however, tends to delayed, especially relatively normal intelligence.To investigate occurrence Mongolian spots syndrome, and clarify relationship between clinically histopathologically.Seven Japanese boys who had received HSCT at ages 4-11 years...
Background:Tenascin-C (TN-C) is an extracellular matrix glycoprotein that heavily upregulated at sites of inflammation. We conducted a retrospective study to assess the utility TN-C as novel biomarker predict risk developing coronary artery lesions (CAL) and resistance intravenous immunoglobulin (IVIG) in patients with Kawasaki disease (KD).
Due to the significant spread of a new type coronavirus (SARS-CoV-2) infection (COVID-19) in China, Chinese government blockaded several cities Hubei Province. Japanese citizens lost means transportation return back Japan. The National Center for Global Health and Medicine (NCGM) helped operation charter flights evacuation residents from Province, this article outlines our experiences. A total five were dispatched, majority returnees (793/829 [95.7%]) handled at NCGM. large number personnel...
Background Viruses may induce primary as well secondary hemophagocytic lymphohistiocytosis (HLH), but it not be possible to discriminate between these two in patients with a negative family history. Among HLH cases, fulminant and fatal virus-associated syndrome (VAHS) occurs mostly relation Epstein-Barr virus (EBV) infection. Although the immunological characteristics of EB-VAHS were previously reported, data on non-EB-VAHS sporadic fragmentary. This study has compared clearly...
Recent reports have shown a correlation between extensive Mongolian spots and mucopolysaccharidosis type II (Hunter syndrome). However, statistical survey of the incidence natural history among patients with Hunter syndrome is lacking.To determine prevalence spots, to course according age in Japanese syndrome, compare them results obtained from patients' brothers who did not syndrome.Fifty-two males aged 3 40 years were studied. Twenty-five examined two clinics existence characteristics...
Neuroblastoma (NB) is the most common malignant solid tumor in childhood, and among all childhood malignancies second prevalence only to leukemia. In NB we need both make an accurate diagnosis rapidly analyze expression of genetic prognostic factors such as MYCN, H-ras, trkA. Moreover, it has recently become important survivin mRNA, a member inhibitor apoptosis protein family. Expression gene related tumorigenesis inhibition some tumors. We investigated its by reverse...
Multisystem inflammatory syndrome in children (MIS-C) is a severe disease that reportedly linked to coronavirus 2019. Affected patients present with gastrointestinal symptoms and cardiovascular dysfunction, addition Kawasaki disease-like features, suggesting the potential for overlapping mechanisms. has been reported among individuals of East Asian ethnicities, whereas there minimal clinical literature regarding occurrence MIS-C ethnicities. A few reports thus far have described changes...
The authors describe a 15-year-old boy with hepatosplenic γδ T-cell lymphoma associated hemophagocytic syndrome (HPS) along isochromosome 7q and trisomy 8. He presented prolonged fever, mild anemia, thrombocytopenia, hepatosplenomegaly. Physical examination, radiography, ultrasound tomography revealed no lymphoadenopathy. had elevated levels of serum ferritin, interferon-γ, soluble interleukin-2 receptor, interleukin-6. Bone marrow aspirate showed hypercellularity 50% lymphoblasts...
Abstract Purpose Survival rates of patients with high‐risk neuroblastoma are unacceptable. A time‐intensified treatment strategy delayed local to control systemic diseases has been developed in Japan. We conducted a nationwide, prospective, single‐arm clinical trial treatment. This study evaluated the safety and efficacy surgery increase intensity. Patients methods Seventy‐five were enrolled this between May 2011 September 2015. Delayed consisted five courses induction chemotherapy...
Neuroblastoma (NB), which is a malignant tumor of young children derived from neural crest cells that occurs in children, exhibits wide range clinical behaviors, spontaneous regression to rapid progression. Advanced NB patients have poor prognosis, and recently, autologous bone marrow transplantation (BMT) peripheral blood stem cell (PBSCT) been attempted improve the prognosis these patients. In this study, we detect expression tyrosine hydroxylase (TH), neuroendocrine protein gene product...
Neuroblastomas (NBs) exhibit broad and divergent clinical behaviors tumor risk classification at diagnosis is crucial for the selection of an appropriate therapeutic strategy each patient. The present study aimed to validate relevance International Neuroblastoma Risk Group (INRG) prognostic genomic markers in a Japanese NB cohort using retrospective analysis. Follow-up data based on 30 common INRG queries 605 cases diagnosed Japan between 1990 2014 were collected genome signature sample was...
Ewing's sarcoma (ES) is one of the most malignant tumors bone and soft tissue in children young adults. ES belongs to a group small round cell (SRCTs) that also includes neuroblastoma, rhabdomyosarcoma, lymphoma. However, exhibits several specific chimeric genes (EWS–FLI1, EWS–ERG, EWS–ETV1, EWS–E1AF, EWS–FEV) caused by chromosomal translocations are not shared other SRCTs. These regulate expression various genes; is, they activate inhibitors DNA binding 2 (Id2) gene or suppress transforming...
Neuroblastoma (NB) is the most common malignant solid tumor in childhood. There are well-recognized prognostic factors NB such as age at diagnosis, organ of origin, stages, MYCN gene amplification, and expression H-ras, trkA survivin. Moreover, we investigated vascular endothelial growth factor (VEGF), tyrosine hydroxylase (TH), p53, stem cell (SCF) c-kit its receptor with quantitative real-time polymerase chain reaction (PCR) 22 NBs 4 other tumors (one lymphoma, one teratoma, 2...
Abstract Purpose Perifosine is an alkylphospholipid analog that inhibits or modulates signaling through signal transduction pathways such as Akt, which enhanced in neuroblastoma (NB) by activation of tyrosine kinase receptors. We conducted a phase I study perifosine Japanese patients with recurrent refractory NB. Experimental Design All enrolled were over 2 years age; all had relapsed NB and performance status greater than 50%. was orally administered at loading dose (100–300 mg) on day 1...