A5042678803- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Herpesvirus Infections and Treatments
- Low-power high-performance VLSI design
- SARS-CoV-2 detection and testing
- Semiconductor materials and devices
- Poxvirus research and outbreaks
- COVID-19 and Mental Health
- COVID-19 and healthcare impacts
- Bacillus and Francisella bacterial research
- Infection Control and Ventilation
- Advancements in Semiconductor Devices and Circuit Design
- Magnetic properties of thin films
- Mass Spectrometry Techniques and Applications
- Rare-earth and actinide compounds
- Graphene research and applications
- COVID-19 epidemiological studies
- Urticaria and Related Conditions
- Spine and Intervertebral Disc Pathology
- Restraint-Related Deaths
- Ferroelectric and Negative Capacitance Devices
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Respiratory viral infections research
- Dermatology and Skin Diseases
National Center for Global Health and Medicine
2017-2025
Kyowa Kirin (Japan)
2022-2024
Center for Global Health
2020-2024
Tohoku University
1983-2023
Suzuki (Japan)
2003-2023
Kyushu University Hospital
2023
University of Yamanashi
2023
Tokyo Metropolitan Geriatric Hospital
2023
Japan Anti Tuberculosis Association
2023
University of Tsukuba
2000-2022
We report the local atomic and electronic structure of a nitrogen-doped graphite surface by scanning tunnelling microscopy, spectroscopy, X-ray photoelectron first-principles calculations. The was prepared nitrogen ion bombardment followed thermal annealing. Two types species were identified at level: pyridinic-N (N bonded to two C nearest neighbours) graphitic-N three neighbours). Distinct states localized {\pi} found appear in occupied unoccupied regions near Fermi level carbon atoms...
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with higher transmission potential have been emerging globally, including SARS-CoV-2 from the United Kingdom and South Africa. We report 4 travelers Brazil to Japan in January 2021 infected a novel variant an additional set of mutations.
BackgroundTo develop an effective vaccine against a novel viral pathogen, it is important to understand the longitudinal antibody responses its first infection. Here we performed study of SARS-CoV-2 in symptomatic patients.MethodsSequential blood samples were collected from 39 individuals at various timepoints between 0 and 154 days after onset. IgG or IgM titers receptor binding domain (RBD) S protein, ectodomain N protein determined by using ELISA. Neutralizing measured plaque reduction...
Significance Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are of concern, with the P.1 dominating in Brazil. Brazil is now seeing a record number deaths. Here, we report that pathogenicity hamsters variant similar to nonvariant SARS-CoV-2. However, it has an expanded host range as shown by its replication mice. Prior infection SARS-CoV-2 strains efficiently prevented lower tract upon reinfection. Convalescent sera from patients infected nonvariants or messenger RNA...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing disease 2019 (COVID-19) was announced as an outbreak by World Health Organization (WHO) in January 2020 and a pandemic March 2020. The majority of infected individuals have experienced no or only mild symptoms, ranging from fully asymptomatic cases to pneumonic disease. However, minority develop severe symptoms. objective this study identify susceptible HLA alleles clinical markers that can be used risk...
BackgroundVaccination against mpox (formerly known as monkeypox), an infectious disease caused by the monkeypox virus (MPXV), is needed to prevent outbreaks and consequent public health concerns. The LC16m8 vaccine, a dried cell-cultured proliferative live attenuated vaccinia virus–based was approved in Japan smallpox mpox. However, its immunogenicity efficacy MPXV have not been fully assessed. We assessed safety of healthy adults.MethodsWe conducted single-arm study that included 50...
Study Design. Review of the clinical and radiologic records patients who underwent one-level posterior lumbar interbody fusion (PLIF) at L4–L5. Objective. To determine whether adjacent intervertebral disc degeneration after PLIF affects results, preoperative caudal (L5–S1) postoperative results. Summary Background Data. There is little reliable information in literature regarding results PLIF. Methods. Forty-five L4–L5 for spondylolisthesis with more than 5 years observation were included...
An investigation of the relation between intraoperative insertional torque pedicle screws, bone mineral density vertebra, and development screw loosening in vivo.To determine usefulness measurement screws.Some biomechanical studies have demonstrated that is highly correlated with stability screws vitro.Pedicle fixation was performed posterior lumbar interbody fusion 62 consecutive patients. The mean age patients at time surgery 58 years. measured intraoperatively all follow-up period 2.7...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzymic synthesis of selenocysteine in rat liverNobuyoshi Esaki, Takeshi Nakamura, Hidehiko Tanaka, Tetsuya Suzuki, Yoshimasa Morino, and Kenji SodaCite this: Biochemistry 1981, 20, 15, 4492–4496Publication Date (Print):July 21, 1981Publication History Published online1 May 2002Published inissue 21 July 1981https://pubs.acs.org/doi/10.1021/bi00518a039https://doi.org/10.1021/bi00518a039research-articleACS PublicationsRequest reuse permissionsArticle...
<b><i>Introduction:</i></b> Old age is an independent risk factor (RF) for severe COVID-19; evidence clinico-epidemiological characteristics among elderly COVID-19 patients scarce. We aimed to analyze clinical and epidemiological comorbidities associated with inpatients in age-stratified populations of cohort. <b><i>Methods:</i></b> conducted a retrospective cohort study, using nationwide registry data hospitalized before October 31, 2020...
Abstract The role of endogenous tumor necrosis factor alpha (TNF-alpha) and interferon-beta (IFN-beta) in lipopolysaccharide (LPS)-induced activation the inducible nitric-oxide synthase (i-NOS) gene was investigated. By Northern analysis or reverse-transcription polymerase chain reaction, mouse macrophage cell line (J774) found to respond LPS treatment by increased expression mRNAs specific for TNF-alpha, IFN-beta, i-NOS with kinetics unique each gene. Bioassay culture supernatants showed...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic action of L-methionine .gamma.-lyase on selenomethionine and selenolsNobuyoshi Esaki, Hidehiko Tanaka, Sakae Uemura, Tetsuya Suzuki, Kenji SodaCite this: Biochemistry 1979, 18, 3, 407–410Publication Date (Print):February 6, 1979Publication History Published online1 May 2002Published inissue 6 February 1979https://pubs.acs.org/doi/10.1021/bi00570a003https://doi.org/10.1021/bi00570a003research-articleACS PublicationsRequest reuse...
Nitrogen doping of a graphite surface by ion bombardment has been found to enhance the durability deposited Pt clusters for H2−D2 exchange reaction. Scanning tunneling microscopy suggests that this high is originated from stabilized monolayer morphology clusters. From comparison with case argon bombardment, ascribed nitrogen-doping effect such as an electron doping, which enhances interface interaction between cluster and rather than dangling carbon atoms at vacancy.
Under perpendicular external magnetic fields, two-dimensional carriers exhibit Landau levels (LLs). However, it has recently been reported that LLs have observed on graphene and graphite surfaces without fields being applied. These anomalous ascribed primarily to a strain of sheets, leading in-plane hopping modulation electrons. Here, we report the observation massive Dirac fermions atomically flat areas nitrogen-doped surface in absence fields. The corresponding were estimated be as much...
We report a case of varicella zoster virus (VZV) meningitis following BNT162b2 mRNA COVID-19 vaccination in an immunocompetent patient. A final diagnosis was made based on identification VZV via positive polymerase chain reaction cerebrospinal fluid along with characteristic symptoms such as fever, headache, and stiff neck. This phenomenon has been reported elsewhere; this is the 13th worldwide 7th patients, indicating need for careful monitoring after vaccines.
Secretory immunoglobulin A (IgA) plays a crucial role in mucosal immunity for preventing the invasion of exogenous antigens; however, little is understood about neutralizing activity serum IgA. Here, to examine IgA antibodies against COVID-19 illnesses, we determined serum/plasma IgG and purified from previously SARS-CoV-2-infected mRNA vaccine-receiving individuals. We found that possesses substantial but rather modest SARS-CoV-2 compared with no significant correlation disease severity....
In sub-100-nm generation, gate-tunneling leakage current increases and dominates the total standby of LSIs based on decreasing gate-oxide thickness. Showing that gate is effectively reduced by lowering voltage, we propose a local dc level control (LDLC) for SRAM cell arrays an automatic suppression driver (AGLSD) peripheral circuits. We designed fabricated 32-kB 1-port using 90-nm CMOS technology. The six-transistor size 1.25 /spl mu/m/sup 2/. Evaluation shows 1.2 mu/A at V room temperature....
Abstract In early 2020, Japan repatriated 566 nationals from China. Universal laboratory testing and 14-day monitoring of returnees detected 12 cases severe acute respiratory syndrome coronavirus 2 infection; initial screening results were negative for 5. Common outcomes remaining asymptomatic (n = 4) pneumonia 6). Overall, performed poorly.
Abstract Objective To evaluate the efficacy and safety of direct hemoperfusion using a polymyxin B‐immobilized polystyrene column (PMX‐DHP) in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐positive pneumonia patients. Methods This study was case series conducted at designated infectious diseases hospital. Twelve SARS‐CoV‐2‐positive patients with partial pressure arterial oxygen/percentage inspired oxygen (P/F) ratio < 300 were treated PMX‐DHP on two consecutive days each...
Carbapenem-resistant Gram-negative bacilli (CRGNB), especially Enterobacterales, Pseudomonas aeruginosa and Acinetobacter baumannii, are critical pathogens associated with excess morbidity mortality. To elucidate their molecular epidemiology clinical outcomes in Japan, patients CRGNB were enrolled the MDR organisms research network (MDRnet) consisting of eight tertiary care facilities. Between 2019 2022, 246 unique carbapenem-resistant Enterobacterales (CRE), P. (CRPA) A. baumannii (CRAB)...
Among patients with coronavirus disease 2019 (COVID-19), the factors that affect anti-severe acute respiratory syndrome 2 (SARS-CoV-2) antibody production remain unclear. This study aimed to identify such among convalescing from COVID-19.This comprised who had been diagnosed COVID-19 between January 1 and June 30, 2020 gave consent for anti-SARS-CoV-2 spike protein measurement using enzyme-linked immunosorbent assay during their and/or convalescent phases. Factors related elevated titers...